Myeloperoxidase Activity and Bactericidal Function of PMN in Iron Deficiency

Yetgin, Sevgi; Altay, Çiğdem; Ciliv, G; Lâleli, Yahya

doi:10.1159/000207620

Cited by 37 publications

(28 citation statements)

References 15 publications

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“…In addition, defective neutrophil dicating selenium insufficiency in chronic iron deficiency bactericidal capacity due to iron deficiency may be exanemia accompanied by low GSH-Px activity in red cells plained to some extent by this interpretation [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

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Serum Selenium Status in Children with Iron Deficiency Anemia

Yetgin

Hıncal²,

Baçaran³

et al. 1992

Acta Haematol

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Serum selenium concentration was investigated in 40 children with iron deficiency anemia and in 40 control subjects matched for age, sex and geographical origin. A spectrofluorometric method was used for determination of the selenium level. It was found to be significantly lower (p < 0.001) in the patient group, which consisted of both normally developed and malnourished children. Patients also having pica had higher levels of selenium compared to patients without pica. There was no relation between the serum selenium concentration and hematological parameters such as hemoglobin, serum iron, serum iron binding capacity and unsaturated iron binding capacity. However the results of 15 patients followed during iron therapy indicated that the duration of the anemic period may affect the selenium concentration. This study also suggests the effectiveness of iron and selenium administration.

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Section: Discussionmentioning

confidence: 99%

“…It might also shed some light on the neutrophil bac tericidal defect observed in iron deficiency and/or sele nium deficiency [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Serum Selenium Status in Children with Iron Deficiency Anemia

Yetgin

Hıncal²,

Baçaran³

et al. 1992

Acta Haematol

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“…Neutrophil myeloperoxidase, an iron metalloenzyme that generates reactive bactericidal halides during PMN phagocytosis, is reduced in iron deficiency states Turgeon-O'Brien et al, 1985;Yetgin et al, 1979). Myeloperoxidase-mediated killing is a redundant system; however, iron is also required for the production by phagocytic cells of reactive microbicidal oxygen species via the Fenton reaction .…”

Section: Effects Of Iron Deficiency On Immune Functionmentioning

confidence: 99%

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Poos¹,

Costello²,

Carlson-Newberry³

1999

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The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The image adopted as a logotype by the Institute of Medicine is based on a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.Cover: Resting monocyte/macrophage being activated to produce proinflammatory cytokines which form complexes with receptor binding proteins. Adapted from COMMITTEE ON MILITARY NUTRITION RESEARCHROBERT O. NESHEIM (Chair, through June 30, 1998) (FNB), Institute of Medicine, National Academy of Sciences. Other workshops or symposia have included such topics as food components to enhance performance; nutritional needs in hot, cold, and high-altitude environments; body composition and physical performance; nutrition and physical performance; cognitive testing methodology; and fluid replacement and heat stress. These workshops form part of the response that the CMNR provides to the Commander, U. HISTORY OF THE COMMITTEEThe CMNR was established in October 1982 following a request by the Assistant Surgeon General of the Army that the Board on Military Supplies of the National Academy of Sciences set up a special committee. The purpose of this committee was to advise the U.S. Department of Defense on the need for and conduct of nutrition research and related issues. The CMNR was transferred to the FNB in 1983. The CMNR's current tasks are• to identify nutritional factors that may critically influence the physical and mental performance of military personnel under all environmental extremes,• to identify deficiencies in the existing database, • to recommend research that would remedy these deficiencies as well as approaches for studying the relationship of diet to physical and mental performance, and• to review and advise on standards for military feeding systems.Within this context, the CMNR was asked to focus on nutrient requirements for performance during operational missions rather than requirements for military personnel in garrison (the latter were judged to be not significantly different from those of the civilian population).Although the membership of the committee has changed periodically, the disciplines represented consistently have included human nutrition, nutritional biochemistry, performance physiology, food science, and psychology. For issues that require broader expertise than exists within the committee, the CMNR has convened workshops or utilized consultants. The workshops provide additional state-of-the-art scientific information and informed opinion for the consideration of the committee. COMMITTEE TASKS AND PROCEDURESThe request for this review of nutrition and immune function and its application to military operations originated with Army scientists from USARIEM and USAMRMC. In December 1995, a committee subgroup of the CMNR participated in a series of conference calls with USARIEM, USAMRMC, and other CMNR members to identify the key areas that should be reviewed and to solicit suggestions for names...

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“…Sub jects with ACD suffered from infections [5], inflammatory [8] or neoplastic [2] diseases. The mean age was 48 ±10 years for the IDA …”

Section: Patient Selectionmentioning

confidence: 99%

“…There is also prevailing opinion that intracellular bacterial killing by PMNs is impaired in the iron-defi cient state [5][6][7], Although Arbeter et al [7] reported that a deficiency in MPO activity was responsible for the abnormal function of PMNs, Yetgin et al [8] found normal values for MPO in IDA. Thus, there is some controversy on the role of iron in bactericidal capacity of PMNs in IDA, while this aspect of im munocompétence is not well documented in ACD.…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase Activity of Polymorphonuclear Leukocytes in Iron Deficiency Anemia and Anemia of Chronic Disorders

Turgeon-O’Brien¹,

Amiot²,

Lemieux³

et al. 1985

Acta Haematol

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Myeloperoxidase (MPO) activity was studied in adults with iron deficiency anemia (IDA) or anemia of chronic disorders (ACD). MPO activity (biochemical quantitation) was found to be decreased in IDA when compared to the control group (p < 0.05); ACD subjects also had lower values although the difference was not significant (p > 0.05). MPO scores (MPO staining) were significantly lower in IDA and ACD subjects than in the healthy control group (p < 0.05). A significant positive correlation was noted between ferritin (R = 0.40) and percent transferrin saturation (R = 0.37) and MPO activity (p < 0.001) in IDA and for the healthy controls

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Myeloperoxidase Activity and Bactericidal Function of PMN in Iron Deficiency

Cited by 37 publications

References 15 publications

Serum Selenium Status in Children with Iron Deficiency Anemia

Serum Selenium Status in Children with Iron Deficiency Anemia

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Myeloperoxidase Activity of Polymorphonuclear Leukocytes in Iron Deficiency Anemia and Anemia of Chronic Disorders

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