Myelopathy in sickle cell disease: a case-oriented review

Brum, Igor Vilela; Silva, Guilherme Diogo; Sodre, Diego Sant'Ana; Nogueira, Felipe Melo; Pereira, Samira Luisa dos Apostolos; Castro, Luiz Henrique Martins

doi:10.1038/s41394-021-00449-8

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…It might be challenging to diagnose by an emergency room doctor [ 10 ]. Myelopathy has been infrequently characterized, with few published cases of compressive and ischemic myelopathy, even though neurological problems in sickle cell patients are widely known [ 11 ]. An MRI is helpful to find out other acute myelopathy causes, such as transverse myelitis, demyelination lesions, tumour constriction of the cord, spondylosis, and disc herniations [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

A Sporadic Case of a 22-Year-Old Female With Spinal Cord Infarction (SCI) Complicated by SS Pattern Sickle Cell Disease (SCD): A Rare Case Report

Umalkar¹,

Chavan²,

Kantode³

et al. 2022

Cureus

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A stroke that occurs either in arteries that supply the spinal cord or the spinal cord itself is called spinal cord infarction (SCI). The lower thoracic area is the most typical site for spinal cord infarcts. Spinal infarcts are rare even among people without sickle cell disease, making up only a very less amount of all infarcts to the central nervous system. A 22-year-old female with a known case of SS pattern sickle cell anaemia was brought by her parents to the emergency medicine department with a complaint of pain in the bilateral upper and right lower limbs. The pain progressed to weakness within 15 minutes, which was sudden in onset and associated with faecal and urine incontinence. On physical examination of the client, her Glasgow coma scale (GCS) was E3 VT M5, pupils were bilateral and equally reactive to light, in both upper limbs, the power was 0/5 and 2/5 in the left lower limb, and hypotonia in the upper and right lower limb was noted. Still, the tone was expected in the left lower limb. MRI showed myelopathy extending over three segments from c2 to c4 involving predominantly anterior aspect, most likely cord ischemia. The patient was treated in the neurocritical care unit with tab Ecosprine 150 mg, multivitamins, and rehabilitative therapy. After two months, she showed gradual but consistent improvement in restoring some motor function in her affected limbs. SCIs are uncommon. Although ischemic stroke can be treated with anticoagulants and antiplatelet medicines, viable therapies for SCI have not yet been identified.

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Section: Discussionmentioning

confidence: 99%

A Sporadic Case of a 22-Year-Old Female With Spinal Cord Infarction (SCI) Complicated by SS Pattern Sickle Cell Disease (SCD): A Rare Case Report

Umalkar¹,

Chavan²,

Kantode³

et al. 2022

Cureus

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“…Tanda dan gejala yang umum terjadi meliputi nyeri (punggung, perut, dada), kelainan sensorik, kelemahan pada lengan atau kaki, dan masalah kandung kemih dan usus (Abbatemarco et al, 2021). Gejala biasanya dimulai secara unilateral, ipsilateral terhadap ruam, tetapi kemudian menjadi bilateral (Brum et al, 2021). Gejala yang tidak khas ini menyebabkan kesalahan diagnosis yang menyebabkan progresivitas penyakit terus terjadi.…”

Section: Pembahasanunclassified

Case Report Of Transverse Myelitis: Rare Neurological Complications Of Herpes Zoster Virus

Khoiruddin

Sasono²

2023

AMS

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Introduction: Transverse myelitis is a rare disease that accured by incident 0,3%-1% Though it rare happened transverse myelitis deserve to diccus because the variant presentation that make clinical challenge to dianosis to pre-observation for upgrade’s prognosis. Case Report: we reported case of transverse myelitis that was neurology complication to rare herpes zoster virus. Woman 27 years old came by early complaint of tingling fever, pain, shiver continue on foot and the right hand. After got well, patient cameback to her disease bacause of the worst condition that cold not mover her left foot. Diagnosis transverse myelitis could stand through clinical sympton and magnetic resonance imaging (MRI) patient that came by her skin of hipopigment have to always considere the happening of transverse myelitis and lost control of defecate on neurologi observation being got paraplegi, monoparese extremitas superior, and hipoanesthesia dermatom C5 on low grade. We got observation of MRI to the level cervicothoracal that show long segment hipeintensity introdural intra medullary to the level craniovertebral junction so C5 and T2 so on that involved 2/3 spinal cord that strength described transverse myelitis. Discussion: Varicella zoster virus cou caused neurologis complication, the of transverse myelitis, of it is sign and sympton like pain, sencoric trouble, weakness on arm and foot, and the problem bladder and intestines. This symptom often occured unilaterally , Ipsilateral toward rash then become bilaterally. Intervention should the customize with pattient complaint: The implement combination asiklovir and high close steroid’s inject significantly relieve the pattient complaining but still occured paraplegi. Keywords: Transverse myelitis, HZV, neurological complication

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Myelopathy in sickle cell disease: a case-oriented review

Cited by 2 publications

References 23 publications

A Sporadic Case of a 22-Year-Old Female With Spinal Cord Infarction (SCI) Complicated by SS Pattern Sickle Cell Disease (SCD): A Rare Case Report

A Sporadic Case of a 22-Year-Old Female With Spinal Cord Infarction (SCI) Complicated by SS Pattern Sickle Cell Disease (SCD): A Rare Case Report

Case Report Of Transverse Myelitis: Rare Neurological Complications Of Herpes Zoster Virus

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