Myelopathy caused by a histiocytic sarcoma in a cat

Smoliga, James M.; Schatzberg, Scott J.; Peters, Jeanine; McDonough, Sean P.; deLahunta, A

doi:10.1111/j.1748-5827.2005.tb00273.x

Cited by 30 publications

(69 citation statements)

References 15 publications

(5 reference statements)

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“…Because HS progresses rapidly, the primary and metastatic sites become indistinguishable; therefore, it is difficult to clinically differentiate disseminated HS and MH. These conditions are uncommon in both dogs and cats [1,4,6,7,10,14,15,17,19,21,22]. Here, we report a case of HS in a cat characterized by excessive hemophagocytosis and the presence of splenic masses.…”

Section: Among Histiocytic Malignancies Histiocytic Sarcoma (Hs) Is mentioning

confidence: 93%

“…In previously reported cases of HS or MH in cats, the affected animals had nonspecific signs, and the laboratory findings commonly included regenerative or nonregenerative anemia and thrombocytopenia [4,6,7,10,21,22]. Additionally, hemophagocytosis was noted in the spleen, liver and bone marrow in some cases [4,6,7,10].…”

Section: Among Histiocytic Malignancies Histiocytic Sarcoma (Hs) Is mentioning

confidence: 99%

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Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat

et al. 2009

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ABSTRACT. A 10-year-old Japanese domestic cat was presented with anorexia and weight loss. Severe anemia and thrombocytopenia were detected. Abdominal radiography and ultrasonography revealed the presence of multiple masses in the spleen. Cytological analyses of the masses revealed several atypical histiocytic cells and considerable hemophagocytosis. A splenectomy was performed, and the mass was diagnosed as histiocytic sarcoma on the basis of histopathological, cytochemical and immunohistochemical analyses. Further, abnormal hemophagocytosis was observed in the bone marrow. The cat was administered prednisolone and lomustine, and it survived for 107 days after admission. An autopsy revealed the presence of neoplastic histiocytic cells in the bone marrow, liver, pancreatic lymph node and glomeruli. This is the first case of histiocytic sarcoma in a cat to be reported in Japan.KEY WORDS: feline, hemophagocytosis, histiocytic sarcoma.

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Section: Among Histiocytic Malignancies Histiocytic Sarcoma (Hs) Is mentioning

confidence: 93%

Section: Among Histiocytic Malignancies Histiocytic Sarcoma (Hs) Is mentioning

confidence: 99%

Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat

et al. 2009

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“…Cats, in contrast, are rarely affected by these diseases [6]. Histiocytic sarcoma (HS) in cats has been reported to date in the intestinal wall, femur, tarsus, spleen and liver, and mediastinal and vertebral canals [1,5,11,13,16]. A brief description of an HS in the central nervous system (CNS) of a cat was reported only in a review article [19], while malignant histiocytic disorders have been well demonstrated in the canine CNS [2,4,14,18,20].…”

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confidence: 99%

Histiocytic Sarcoma in the Brain of a Cat

Uchida

Tamura³

et al. 2010

J. Vet. Med. Sci.

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ABSTRACT. A mass lesion in the subependymal region of the lateral ventricle in a 13-year-old neutered male mongrel cat with a complaint of somnolence, right circling movement and posture abnormality was examined. The magnetic resonance image examination revealed a relatively large T1-hypointense and T2-hyperintense mass lesion in the left interventricular foramen region, and there were no abnormalities in the chest and abdominal x-ray radiographic, funduscopic, and electric retinogram findings. The cat was died 43 days after the initial referral, and the post-mortem examinations revealed a poorly demarcated subependymal mass. Histologically, the brain lesion consisted of complex proliferation of highly pleomorphic cells resembling histiocytes with atypia and abundant mitotic figures. Moderate infiltrates of small reactive lymphocytes were admixed with the pleomorphic cell population. Gemistcytic astrocytes were also intermingled with the periphery of neoplastic foci. Immunohistochemically, most of the pleomorphic cells were positive for HLA-DR alphachain and ionized calcium binding adaptor molecule 1, and few were positive for lysozyme and alpha-1 antichymotrypsin. The atypical pleomorphic cells were negative for CD3, IgG (H and L), glial fibrillary acidic protein and neurofilament, suggesting monocytic/histiocytic-origin of the cells. The number of Ki-67-positive cell nuclei was extremely large, reflecting the high growth activity of these cells. Based on the findings, the lesion was considered as histiocytic sarcoma.KEY WORDS: brain, feline, histiocytic sarcoma, immunohistochemistry.J. Vet. Med. Sci. 72(1): 99-102, 2010 In dogs, histiocytic disorders have been classified into 3 major categories: canine cutaneous histiocytoma; canine reactive histiocytoses (both cutaneous and systemic); and histiocytic sarcoma complex (both localized and disseminated histiocytic sarcoma) [10]. Cats, in contrast, are rarely affected by these diseases [6]. Histiocytic sarcoma (HS) in cats has been reported to date in the intestinal wall, femur, tarsus, spleen and liver, and mediastinal and vertebral canals [1,5,11,13,16]. A brief description of an HS in the central nervous system (CNS) of a cat was reported only in a review article [19], while malignant histiocytic disorders have been well demonstrated in the canine CNS [2,4,14,18,20]. This report documents the features of a brain tumor in a cat. The histological and immunohistochemical natures characterized by the proliferation of highly pleomorphic cells resembling histiocytes and immunoreactivity for HLA-DR and ionized calcium binding adaptor molecule 1 (Iba1) are consistent with HS [7,8,15].A 13-year-old neutered male mongrel cat was presented to a private animal hospital with a complaint of somnolence, blindness, right circling movement and posture abnormality. The neurological examinations revealed a postural reaction decrease, a left mydriasis and disappearance of a physiologic nystagmus. Complete blood cell count and serum biochemical analyses were within normal ranges...

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“…Phagocytosis and multi-nucleated cells are usually seen, although they are not always prominent features. 2,4,6,[9][10][11][12][13] In this cat, the cytoplasm of the neoplastic cells was scant, there was little evidence of phagocytosis, and multi-nucleated giant cells were rare. Because of the absence of typical morphologic features of HS, immunohistochemistry was used to confirm the diagnosis.…”

mentioning

confidence: 99%

“…9 Histiocytic sarcoma (HS) as a solitary tumor has been rarely described in cats and reports to date include an intramural intestinal mass, a femoral mass, and a mediastinal and vertebral canal HS that resulted in a secondary myelopathy. 2,10,11 A brief description of an HS of the central nervous system of a cat was also included in a review article of intraoperative tumor diagnosis in dogs and cats, but without much clinical detail. 12 To the authors' know ledge, this is the first report of an HS involving the joint of a cat.…”

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confidence: 99%

Histiocytic Sarcoma in the Tarsus of a Cat

Pinard¹,

Wagg²,

Girard³

et al. 2006

Vet Pathol

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Abstract.A 12-year-old Persian cat was examined for a firm swelling of the right tarsal region and enlargement of the corresponding right popliteal lymph node. Cytologic evaluation demonstrated a population of malignant cells consistent with large cell lymphoma. Necropsy revealed a multilobulated subcutaneous mass involving the tarsus with some extension into adjacent deep muscular tissue. Histologically, the mass was composed of round cells with eosinophilic cytoplasm and pleomorphic anisokaryotic nuclei. Evidence of articular and nodal infiltration by these cells was observed. Differential diagnoses included synovial sarcoma and histiocytic sarcoma. Neoplastic cells were negative for cytokeratin, CD79a, and CD3 and positive for CD18, vimentin, lysozyme, and alpha-1-antitrypsin, most consistent with a diagnosis of histiocytic sarcoma. This is the first report of a histiocytic sarcoma involving a joint of a cat. The final diagnosis was based on the light microscopic appearance in combination with the immunohistochemical stains.

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Myelopathy caused by a histiocytic sarcoma in a cat

Cited by 30 publications

References 15 publications

Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat

Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat

Histiocytic Sarcoma in the Brain of a Cat

Histiocytic Sarcoma in the Tarsus of a Cat

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