myelomatosis in aplastic anaemia—a true association or fortuitous occurrence?

Manoharan, A.; Horsley, R.; Pitney, W. R.

doi:10.3109/00313028109086651

Cited by 2 publications

(2 citation statements)

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“…However, it is crucial first to identify neoplastic factors, as we did in this case. There have been reports of co-existing multiple myeloma at the time of diagnosis or later in aplastic anemia, although it is very rare [ 8 , 9 ]. There have been reports of developing multiple myeloma after immunosuppressive therapy [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Reactive Plasmacytosis Immediately After Immunosuppressive Therapy With Anti-human Thymocyte Immunoglobulin for Severe Aplastic Anemia: A Report of a Rare Case

Shimada,

Bando,

Takahata

et al. 2024

Cureus

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Aplastic anemia is a hematopoietic deficiency disorder with pancytopenia, and immunosuppressive therapy is effective. We report a case in which plasma cells appeared in the peripheral blood during immunosuppressive therapy for aplastic anemia. Based on the results of morphology and flow cytometry, the plasma cells were considered reactive and disappeared spontaneously after follow-up. Thereafter, the patient had a good hematopoietic recovery. Reactive plasmacytosis has been reported in infectious and autoimmune diseases, but this is the first report of reactive plasmacytosis during immunosuppressive therapy for aplastic anemia, to our knowledge. In this case, reactive plasmacytosis was a sign preceding good hematopoietic recovery.

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Section: Discussionmentioning

confidence: 99%

Reactive Plasmacytosis Immediately After Immunosuppressive Therapy With Anti-human Thymocyte Immunoglobulin for Severe Aplastic Anemia: A Report of a Rare Case

Shimada,

Bando,

Takahata

et al. 2024

Cureus

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“…Manoharan et al reported a case in 1981 [7], and a second case of acquired aplastic anaemia evolving into myelodysplasia and finally myeloma was reported in 1991 [8]. …”

Section: Discussionmentioning

confidence: 99%

CD19 ( ) CD56 (–) myeloma arising in a patient who failed two courses of immunosupressive therapy for aplastic anaemia

Murray¹,

Ruiz²,

Miranda³

2017

ecancer

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Patients diagnosed with severe aplastic anaemia and without a compatible bone marrow transplant donor are treated with immunosuppressive therapy. These patients are found with time to develop a clonal disease such as myelodysplasia or paroxysmal nocturnal haemoglobinuria. However, the development of plasma cell dyscrasias is rare. We report the case here of a patient treated with immunosuppressive therapy who went on to develop myeloma 11 months after being diagnosed with severe aplastic anaemia. We include here a review of the literature.

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myelomatosis in aplastic anaemia—a true association or fortuitous occurrence?

Cited by 2 publications

References 4 publications

Reactive Plasmacytosis Immediately After Immunosuppressive Therapy With Anti-human Thymocyte Immunoglobulin for Severe Aplastic Anemia: A Report of a Rare Case

Reactive Plasmacytosis Immediately After Immunosuppressive Therapy With Anti-human Thymocyte Immunoglobulin for Severe Aplastic Anemia: A Report of a Rare Case

CD19 ( ) CD56 (–) myeloma arising in a patient who failed two courses of immunosupressive therapy for aplastic anaemia

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