Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

Pang, Bo; Hu, Cong; Li, Huimin; Nie, Xinyu; Wang, Keqi; Zhou, Chunmei; Yi, Huanfa

doi:10.3389/fimmu.2023.1080391

Cited by 8 publications

(3 citation statements)

References 135 publications

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“…Presumably, hypoxia, low pH and other tumor microenvironmental factors do not support survival PMN-MDSC [15]. Interestingly, Medical Immunology (Russia)/Meditsinskaya Immunologiya Медицинская Иммунология PMN-MDSC predominates in decidua and blood during pregnancy [9]. In our study, both types of PSG (1 μg/mL nPSG and 10 μg/mL nPSG and rPSG) increased the percentage of M-MDSC in the general MDSC population, and recombinant PSG at a concentration of 10 μg/mL significantly inhibited the formation of PMN-MDSC.…”

Section: Resultsmentioning

confidence: 99%

Effect of pregnancy-specific β1-glycoprotein on myeloid-derived suppressor cell differentiation

et al. 2023

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population that primarily suppress T lymphocytes in healthy pregnancies and pathologies. MDSCs are one of the key regulators of immune responses. Finding ways to control them is important for the treatment of cancer, autoimmune diseases, miscarriage, and post-transplant complications. The mechanisms of immune suppression by MDSC are: expression of CD73, ADAM17, PD -L1, production of Arg 1, iNOS, IDO, IL -10 and TGF-b1.Pregnancy-specific b1-glycoprotein (PSG) has modulatory effects on dendritic cells and macrophages that mediate the shift of T cell phenotypes toward Th2 and Treg. We have previously shown that native PSG suppresses Th17 differentiation and cytokine production, stimulates the production of IDO by monocytes and the differentiation of Tregs.Considering the immunomodulatory properties of PSG and the key role of MDSCs in pathologies, the aim of our work was to investigate the effect of native and recombinant PSG on the differentiation of MDSCs in vitro.MDSCs were differentiated from CD11b+ peripheral blood cells. Cells were cultured for 7 days and received stepwise GM-CSF, IL-1b, and LPS. Native (n) (1; 10 and 100 mg/mL) and recombinant (r) (1 and 10 mg/mL) PSG were introduced into the cultures three days before the end of incubation. Flow cytometry was used to determine the percentage of MDSC among the cells in culture and the percentage of M-, PMN-, and e-MDSC among the total number of MDSCs.It was found that rPSG (1 mg/mL) increased the percentage of MDSCs in culture. Both nPSG (1 and 10 mg/mL) and rPSG (10 mg/mL) increased the proportion of M-MDSC, whereas rPSG (10 mg/mL) decreased the number of PMN-MDSC.Thus, the cytokine background in CD11b+ cell cultures favored the differentiation of predominantly M-MDSC, similar to the tumor microenvironment, whereas native and recombinant PSG enhanced this effect. Thus, nPSG and rPSG are able to modulate the differentiation of MDSCs by increasing their number, mainly due to the monocytic subpopulation. This fact opens perspectives for new research on targeted manipulation of MDSCs.

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Section: Resultsmentioning

confidence: 99%

Effect of pregnancy-specific β1-glycoprotein on myeloid-derived suppressor cell differentiation

et al. 2023

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“…MDSCs express the receptor for HLA-G, known as immunoglobulin-like transcript 4 (ILT4). Research has demonstrated that HLA-G can activate STAT3 through ILT4, inducing the production of indoleamine 2,3-dioxygenase (IDO), which in turn promotes immune tolerance to maintain normal pregnancy ( 47 , 48 ). In early pregnancy, elevated levels of estradiol and progesterone in women’s serum activate the ILT4/STAT3 signaling pathway to promote the expansion of MDSCs.…”

Section: The Function Of the Stat Signaling Pathways In Normal Pregnancymentioning

confidence: 99%

Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders

Li,

Zhang,

et al. 2024

Front. Immunol.

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Signal transducer and activator of transcription (STAT) proteins, pivotal regulators of signaling cascades, undergo activation in response to the stimulation of cytokines and growth factors, and participate in biological processes, including inflammation, immune responses, cell proliferation, and differentiation. During the process of pregnancy, STAT signaling is involved in regulating embryonic implantation, endometrial decidualization, and establishing and maintaining maternal-fetal immune tolerance. Increasing evidence suggests that aberrant STAT signaling contributes to the occurrence and development of pregnancy disorders, including repeated implantation failure (RIF), preeclampsia (PE), recurrent spontaneous abortion (RSA), preterm birth (PTB) and gestational diabetes mellitus (GDM). Elucidating the molecular mechanisms of the STAT signaling pathway holds promise for further understanding the establishment and maintenance of normal pregnancy, and thereby providing potent targets and strategic avenues for the prevention and management of ailments associated with pregnancy. In this review, we summarized the roles of the STAT signaling pathway and its related regulatory function in embryonic implantation, endometrial decidualization, and maternal-fetal immune tolerance. In conclusion, in-depth research on the mechanism of the STAT signaling pathway not only enhances our understanding of normal pregnancy processes but also offers STAT-based therapeutic approaches to protect women from the burden of pregnancy-related disorders.

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“…Immune crosstalk at maternal-fetal interface is considered to play an especially important role for pregnancy maintenance. [122][123][124] However, the quality of oocytes and antioxidants treatment are found equally crucial to determine the developmental potential of embryos, recently. [125][126][127][128] CoQ10 Protects Embryo Development…”

Section: Coq10 and Pregnancy Maintenancementioning

confidence: 99%

Coenzyme Q10 Stimulate Reproductive Vatality

Nie,

Dong,

et al. 2023

DDDT

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Female infertility and pregnancy maintenance are associate with various factors, including quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases. Women are even diagnosed as unexplained infertility or unexplained recurrent spontaneous abortion when failed to achieve pregnancy with current treatment, which are urgent clinical issues need to be addressed. Coenzyme Q10 (CoQ10) is a lipid-soluble electron carrier in the mitochondrial electron transport chain. It is not only essential for the mitochondria to produce energy, but also function as an antioxidant to maintain redox homeostasis in the body. Recently, the capacity of CoQ10 to reduce oxidative stress (OS), enhance mitochondrial activity, regulate gene expression and inhibit inflammatory responses, has been discovered as a novel adjuvant in male reproductive performance enhancing in both animal and human studies. Furthermore, CoQ10 is also proved to regulate immune balance, antioxidant, promote glucose and lipid metabolism. These properties will bring highlight for ovarian dysfunction reversing, ovulation ameliorating, oocyte maturation/fertilization promoting, and embryonic development optimizing. In this review, we systematically discuss the pleiotropic effects of CoQ10 in female reproductive disorders to investigate the mechanism and therapeutic potential to provide a reference in subsequent studies.

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Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

Cited by 8 publications

References 135 publications

Effect of pregnancy-specific β1-glycoprotein on myeloid-derived suppressor cell differentiation

Effect of pregnancy-specific β1-glycoprotein on myeloid-derived suppressor cell differentiation

Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders

Coenzyme Q10 Stimulate Reproductive Vatality

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