Myeloid transformation of plasma cell myeloma: molecular evidence of clonal evolution revealed by next generation sequencing

Gralewski, Jonathon H.; Post, Ginell R.; Rhee, Frits van; Yuan, Youzhong

doi:10.1186/s13000-018-0692-1

Cited by 3 publications

(1 citation statement)

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“…Another suggested mechanism is that the MM will lead to the activation of numerous gene expression profiles and molecular pathways leading to the formation of myeloid neoplasm. A recently published case report described the transdifferentiation of myeloid sarcoma from PCM, where next-generation sequencing demonstrated a clonal relationship between the PCM and transferred tumor cells, including loss of tumor suppressor gene, and multiple clonal mutations in the RAS pathway [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Transient Pleural Fluid Infiltration by Clonal Plasma Cells Associated with Pulmonary Tuberculosis

et al. 2020

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Pleural effusion is a rare presentation of plasma cell myeloma, occurring in around 6% of patients during the course of their disease, most commonly as a consequence of a concurrent disease process like heart failure secondary to amyloid deposition. Direct infiltration of the pleural fluid by malignant cells leading to myelomatous pleural effusion is a rare mechanism occurring in less than 1% of patients with plasma cell myeloma, and it is associated with a worse prognosis. There are few case reports of myelomatous pleural effusion as an initial presentation of multiple myeloma. Pleural fluid infiltration by monoclonal plasma cells in the absence of an underlying plasma cell myeloma was not reported before in the literature. Tuberculosis is a known cause of polyclonal gammaglobulinemia, however few case reports described the coexistence of monoclonal gammopathy of undetermined significance and tuberculosis. Here we present an interesting case of pleural fluid infiltration by an abnormal looking clonal plasma cells associated with active pulmonary tuberculosis and parapneumonic effusion in a patient with a background of acute myeloid leukemia. Interestingly, the clonal plasma cell proliferation was confined to the pleural fluid without any evidence of an underlying plasma cell neoplasms (including monoclonal gammopathy of undetermined significance and plasmacytomas). Since our patient had an underlying meyloid neoplasm, we though about the possibility of secondary malignancy. However, in almost all patients with coexisting

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Section: Discussionmentioning

confidence: 99%