Myeloid Sarcoma of the Breast Mimicking Hamartoma on Sonography

Lim, Hyo Soon; Park, Min Ho; Heo, Suk Hee; Kim, Jinwoong; Chang, Nam Kyu; Song, Sang Gook; Kang, Heoung Keun

doi:10.7863/jum.2008.27.12.1777

Cited by 6 publications

(9 citation statements)

References 8 publications

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“…On ultrasound, BL manifested typically as hypoechoic microlobulated or indistinct lesions. They were hypervascularized on color Doppler (7, 13, 45,64,66,67,71,94,112).…”

Section: Imaging Findingsmentioning

confidence: 99%

Breast leukemia: an update

Surov

Wienke

Abbas³

2012

Acta Radiol

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“…On ultrasound, BL manifested typically as hypoechoic microlobulated or indistinct lesions. They were hypervascularized on color Doppler (7, 13, 45,64,66,67,71,94,112).…”

Section: Imaging Findingsmentioning

confidence: 99%

Breast leukemia: an update

Surov

Wienke

Abbas³

2012

Acta Radiol

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“…Of particular interest to dermatology are CLL and, for AML, acute myelomonocytic leukemia (AMMoL, FAB-M 4 ) and acute monocytic leukemia (AMoL, FAB-M 5 ), because skin changes are most often seen in these forms of disease. In the literature on hematological disease, the overarching terms myeloid sarcoma and granulocytic sarcoma are also used, given that, along with classic LC, other manifestations such as involvement of the pancreas or vertebral bodies are also included [16][17][18][19]. The frequency is reported at 2.1-30 % depending on the underlying form of leukemia and can precede apparent leukemia by several months or even years.…”

Section: Epidemiology/pathogenesismentioning

confidence: 99%

Leukemia cutis – epidemiology, clinical presentation, and differential diagnoses

Wagner

Fenchel

Back

et al. 2011

J Deutsche Derma Gesell

143

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Keywords• leukemia cutis • acute myeloid leukemia • chronic lymphocytic leukemia • chloroma • myeloid sarcoma • granulocytic sarcoma • gingival hyperplasia Summary Leukemia cutis is an extramedullary manifestation of leukemia. The frequency and age distribution depend on the leukemia subtype. The clinical and morphological findings have a wide range of cutaneous manifestations and may present with nodular lesions and plaques. Rare manifestations include erythematous macules, blisters and ulcers which can each occur alone or in combination. Apart from solitary or grouped lesions, leukemia cutis may also present with an erythematous rash in a polymorphic clinical pattern. Consequently, leukemia cutis has to be distinguished from numerous differential diagnoses, i. e. cutaneous metastases of visceral malignancies, lymphoma, drug eruptions, viral infections, syphilis, ulcers of various origins, and blistering diseases. In the oral mucosa, gingival hyperplasia is the main differential diagnosis. The knowledge of the clinical morphology is of tremendously importance in cases in which leukemia was not yet known.

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“…Myeloid sarcoma can affect any part of the body, and the most commonly affected sites are the lymph nodes, skin, bones, central nervous system, and soft tissue [14]. Breast involvement is rarely observed in myeloid sarcoma [2,13]. In 2005, up to 67 cases of breast myeloid sarcoma were listed in the literature [1]; thereafter, additional cases were sporadically reported until recently [4,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Myeloid sarcoma is a rarely observed hematologic malignancy occurring as a soft tissue mass at extramedullary sites [1,2]. Myeloid sarcomas comprise myeloid cells with variable degrees of maturation and usually manifest simultaneously with or subsequently to the diagnosis of myeloid leukemia [3].…”

Section: Introductionmentioning

confidence: 99%

Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Kim

2019

Am J Case Rep

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Patient: Female, 24 Final Diagnosis: Myeloid sarcoma of the breast Symptoms: Breast lump Medication: — Clinical Procedure: Core needle biopsy Specialty: Radiology Objective: Rare disease Background: Myeloid sarcoma is a rarely observed extramedullary presentation of myeloid leukemia that seldom manifests in the breast. Myeloid sarcoma can occur before, concurrently with, or following acute myeloid leukemia presentation. Few reports have focused on the imaging findings in cases of myeloid sarcoma of the breast, and the existing findings are variable and nonspecific; the present case report aimed to bridge this gap. Case Report: A 24-year-old female presented with a palpable lump at the upper outer quadrant of her right breast. She had noticed the mass 2 days prior to presentation. She was first diagnosed with acute myelogenous leukemia 18 months before the lump presentation and had undergone haploidentical stem cell transplantation 6 months prior. At the time of the breast lump presentation, she was undergoing chemotherapy for relapsed acute myeloid leukemia. Ultrasonography of her right breast revealed a circumscribed, oval mass corresponding to the palpable lump. Ultrasonography-guided 14-gauge core needle biopsy was performed on the breast mass, leading to a pathological diagnosis of myeloid sarcoma. Conclusions: We reported a case of myeloid sarcoma involving the breast. On sonography, although the internal echotexture resembled that of breast hamartoma, the observed hard elasticity and high vascularity raised suspicions of malignancy.

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Myeloid Sarcoma of the Breast Mimicking Hamartoma on Sonography

Cited by 6 publications

References 8 publications

Breast leukemia: an update

Breast leukemia: an update

Leukemia cutis – epidemiology, clinical presentation, and differential diagnoses

Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

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