Myeloid sarcoma of submandibular salivary gland

Dagna, Federico; Giordano, Pamela; Boggio, Valeria; Albera, Roberto

doi:10.1177/2050313x15625016

Cited by 2 publications

(7 citation statements)

References 6 publications

(11 reference statements)

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“…The involvement of MS in the salivary gland is extremely rare, and we identified 17 cases in 13 published reports, including 10 case reports [11–20] and three retrospective reviews [21–23], including this case. Table 1 summarizes the clinical features of MS involving the salivary gland.…”

Section: Resultsmentioning

confidence: 99%

“…Seven cases, including this case, were diagnosed with MS with BM involvement, and one case was diagnosed with MS with BM involvement accompanied with parotid involvement when it recurred three months after the diagnosis of isolated MS in the neck [16]. Two cases developed relapse of AML after allo-HSCT [11, 17]. MS was presented as progression of a prior MDS (2 cases) and MPN (2 cases) (Figure 6) [21].…”

Section: Resultsmentioning

confidence: 99%

“…Finally, the pathologic diagnosis was revised as MS in the neck lymph nodes, with preexisting sebaceous lymphadenoma involvement in the parotid gland. MS with salivary gland involvement is extremely rare, and only a few cases have been reported in the literature [11–23]. Furthermore, the secondary involvement of preexisting benign tumors, especially sebaceous lymphadenomas with lymphoid-rich stroma, is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…MS has a slight male predominance and may occur at any age and in any site of the body, although the most common sites are the lymph nodes, paraspinal area, dura, orbit, skin, soft tissues, bone, mediastinum, lungs, peritoneum, and the gastrointestinal tract [1, 9]. MS in the salivary gland is a rare neoplasm [11]; herein, we report an extremely rare case of MS with BM involvement and neoplastic cell infiltration into a preexisting benign sebaceous lymphadenoma in the parotid gland. Primary MS with salivary gland involvement is difficult to diagnose accurately.…”

Section: Introductionmentioning

confidence: 99%

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Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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“…1 Salivary gland involvement of GS is very rare, more so in case of a CML patient in chronic phase. 2 Here, we present an extremely rare case of GS involving the parotid gland in a previously diagnosed elderly female patient of CML in chronic phase.…”

Section: Introductionmentioning

confidence: 94%

Case Report: Granulocytic Sarcoma of the Parotid in Chronic Myeloid Leukemia: A Case Report and Literature review

Chatterjee,

Hiwale,

Vagha

2024

F1000Res

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Granulocytic sarcomas are infrequent, extramedullary malignant occurrences, generally seen with or secondary to acute myeloid leukemia (AML). Their association with chronic myeloid leukemia (CML) is rare and their appearance in parotid gland is sparsely reported in the literature, as per our literature search. In this report, we present an unusual and rare case of imatinib resistant BCR-ABL1 positive secondary granulocytic sarcoma to CML in chronic phase. The rarity of this clinical presentation presents a diagnostic dilemma, which required the pathologist and the clinician to combine a strong clinical suspicion with cytopathological features to diagnose this case, in order to ensure timely therapeutic modifications (shift from imatinib to second-generation tyrosine kinase inhibitor), considering the improvements in prognosis of imatinib resistant granulocytic sarcomas.

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Myeloid sarcoma of submandibular salivary gland

Cited by 2 publications

References 6 publications

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Case Report: Granulocytic Sarcoma of the Parotid in Chronic Myeloid Leukemia: A Case Report and Literature review

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