Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with 18F-FDG PET/CT

Makis, William; Rakheja, Rajan; Lavoie, Josée; Hickeson, Marc

doi:10.1007/s13139-012-0128-x

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…In 2005 Beyer et al reported a slight male gender predominance; in addition to MLL gene rearrangements described in 19 of the 103 published cases (16%) (9). Our literature search provided 11 new patients with MLL gene rearrangements, bringing the total to 30 cases out of 129 (23.2%) (9,(10)(11)(12)(13)(14). The high occurrence of MLL rearrangements possibly contributes to the adverse prognosis observed in patients with this genotype.…”

Section: Discussionmentioning

confidence: 99%

Polysomy 8 Syndrome: A Distinct Clinical Entity Comprising of Myelomonocytic/Monocytic Lineage Involvement in Acute Leukemia

Yüce¹,

Yüksel²,

Pehlivan³

et al. 2019

J Basic Clin Health Sci

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Purpose: Cytogenetic abnormalities have been proven to be among the most valuable prognostic indicators in leukemia, allowing the stratification of patients in risk groups. We describe a patient diagnosed as AML-M5, with myeloid sarcoma and tetrasomy 8 as the sole chromosomal abnormality. We confirm that the presence of polysomy 8 in myeloid lineage malignancies is associated with a distinct clinical entity comprising of myelomonocytic/monocytic lineage involvement, poor prognosis and high incidence of myeloid sarcoma. In aim to obtain a detailed description of this clinical entity, literature of polysomy 8 cases has been reviewed. Methods: Cytogenetic analysis was performed on bone marrow samples directly after aspiration and following 24 h short term culture. Fluorescence in situ hybridization (FISH) analyses were performed at complete remission stage on interphase nuclei from bone marrow. Results: Cytogenetic analyses revealed tetrasomy 8 as the sole karyotipic change in all metaphases. The presence of tetrasomy was confirmed with C-MYC (8q24), AML1/ETO (ETO-8q21) and chromosome 8 centromeric probe cocktail. Conclusion: Recognition of the polysomy 8 syndrome will allow for the development of a standardized approach to these patients; as well as stimulating further research into the biology of the disorder that will allow for the development of better therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Polysomy 8 Syndrome: A Distinct Clinical Entity Comprising of Myelomonocytic/Monocytic Lineage Involvement in Acute Leukemia

Yüce¹,

Yüksel²,

Pehlivan³

et al. 2019

J Basic Clin Health Sci

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“…14 Long bone involvement usually occurs with multifocal bone involvement, and isolated humerus involvement on FDG PET/CT is rare. [15][16][17][18] Although 18 F-FDG PET/CT is not routinely used to evaluate myeloid sarcoma, it has been shown that FDG PET/CT is useful in disease assessment, staging, relapse detection, therapy response evaluation, and follow-up in myeloid sarcoma. 19,20 Myeloid sarcoma has moderate FDG uptake due to increased glycolytic activity with SUV max in the range of 2.6 to 9.7.…”

mentioning

confidence: 99%

“…Skeletal involvement occurs in 10%-12.5% of myeloid sarcoma cases, with the most common site of involvement being the axial bone 14. Long bone involvement usually occurs with multifocal bone involvement, and isolated humerus involvement on FDG PET/CT is rare [15][16][17][18]. Although 18 F-FDG PET/CT is not routinely used to evaluate myeloid sarcoma, it has been shown that FDG PET/CT is useful in disease assessment, staging, relapse detection, therapy response evaluation, and follow-up in myeloid sarcoma 19,20.…”

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confidence: 99%

18F-FDG PET/CT Imaging of Isolated Myeloid Sarcoma in the Right Humerus

Xie,

Zhang,

Xiao

et al. 2023

Clin Nucl Med

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Myeloid sarcoma is a neoplastic mass formed by the infiltration of primitive or immature myeloid cells into organs and tissues outside the bone marrow. It may occur before, at the same time, or manifest as the recurrence of acute myeloid leukemia, myelodysplastic syndromes, and chronic myeloproliferative syndromes. It may involve any organ or tissue, including skin, soft tissue, lymph nodes, and gastrointestinal tract and bone. Isolated humerus involvement is extremely rare. Herein, we present the FDG PET/CT findings of a rare case of isolate myeloid sarcoma in the right humerus, which showed only increased bone density with moderate FDG uptake.

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18F-FDG PET/CT of Primary Cervical Granulocytic Sarcoma

Zheng

Ouyang²,

Zhang³

et al. 2015

Clinical Nuclear Medicine

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Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with 18F-FDG PET/CT

Abstract: Tetrasomy 8 is a relatively rare chromosomal abnormality that has been reported in only 33 cases in hematologic disorders. It is known for its association with aggressive acute myeloid leukemia (AML) and myeloid sarcoma and is considered a very poor prognostic factor.

Cited by 4 publications

References 20 publications

Polysomy 8 Syndrome: A Distinct Clinical Entity Comprising of Myelomonocytic/Monocytic Lineage Involvement in Acute Leukemia

Polysomy 8 Syndrome: A Distinct Clinical Entity Comprising of Myelomonocytic/Monocytic Lineage Involvement in Acute Leukemia

18F-FDG PET/CT Imaging of Isolated Myeloid Sarcoma in the Right Humerus

18F-FDG PET/CT of Primary Cervical Granulocytic Sarcoma

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