Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes

Altwegg, Lukas; Neidhart, Michel; Hersberger, Martin; Müller, Stephanie; Eberli, Franz R.; Corti, Roberto; Roffi, Marco; Sütsch, Gabor; Eckardstein, Arnold von; Wischnewsky, Manfred; Lüscher, Thomas F.; Maier, Willibald

doi:10.1093/eurheartj/ehm078

Cited by 186 publications

(190 citation statements)

References 33 publications

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“…These findings have implications for the clinical use of these 4 markers of plaque instability and extend both previous clinical and experimental studies (7,8,12,13,15,21 ). The exact mechanisms leading to plaque instability, plaque fissure, and plaque rupture are incompletely understood.…”

Section: Diagnostic Value Of Markers Of Plaque Instabilitysupporting

confidence: 69%

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Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction

Schaub¹,

Reichlin

Meune³

et al. 2012

Clinical Chemistry

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Section: Diagnostic Value Of Markers Of Plaque Instabilitysupporting

confidence: 69%

“…Pilot studies suggested a possible prognostic role for MRP-8/14 in ACS patients (13,14 ). Pregnancy-associated plasma protein A (PAPP-A) is a protease mainly produced by the placenta during pregnancy, but also by fibroblasts, osteoblasts, and vascular smooth muscle cells.…”

mentioning

confidence: 99%

Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction

Schaub¹,

Reichlin

Meune³

et al. 2012

Clinical Chemistry

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“…Moreover, increased S100A8/A9 expression has become a novel, early, and sensitive marker of acute coronary syndromes. [31] Hence the study on the mechanism of S100A8 mediating cerebral I/R injury is of practical value in early diagnosis and prevention of cerebrovascular events.…”

Section: Discussionmentioning

confidence: 99%

Upregulated expression of S100A8 in mice brain after focal cerebral ischemia reperfusion

Sun

Zhang

et al. 2013

World Journal of Emergency Medicine

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BACKGROUND:Recent studies have showed that S100A8 has been implicated in the pathobiology of inflammatory disorders, and that cerebral ischemia reperfusion (I/R) rapidly activates inflammation responses via Toll-like receptor 4 (TLR4). This study aimed to explore the expression of S100A8 and the relationship between S100A8 and TLR4 in focal cerebral ischemia reperfusion injury.METHODS:C3H/HeJ mice (n=30) and C3H/HeN mice (n=30) were divided randomly into a C3H/HeJ model group (n=18), a C3H/HeJ control group (n=12), a C3H/HeN model group (n=18), and a C3H/HeN control group (n=12). Middle cerebral artery I/R model in mice was produced using a thread embolism method. The brains of the mice were collected after ischemia for 1 hour and reperfusion for 12 hours. Stroke outcome was evaluated by determination of infarct volume and assessment of neurological impairment scores. Brain injury after cerebral I/R was observed by an optical microscope after TTC and HE dyeing. The immunofluorescence technique and real time PCR were used to test the expression level of S100A8 in brain damage.RESULTS:Compared with C3H/HeN mice, TLR4-deficient mice (C3H/HeJ) had lower infarct volumes and better outcomes in neurological tests. The levels of S100A8 increased sharply in the brains of mice after I/R injury. In addition, mice that lacked TLR4 (C3H/HeJ) had lower expression of I/R-induced S100A8 than C3H/HeN mice in the model group, indicating that a close relationship might exist between the levels of S100A8 and TLR4.CONCLUSION:S100A8 interaction with TLR4 might be involved in brain damage and in inflammation triggered by I/R injury.

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“…The serum level of S100A8/A9 is associated with an early risk of acute coronary syndromes and the severity of coronary artery disease in diabetic individuals. Previous small sub-group studies also indicate that S100A8/A9 may be a marker of subclinical atherosclerosis, as its elevation in serum corresponds with intima media thickness in patients with diabetes but without any history of previous cardiovascular diseases (CVD) (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Sirtuin-1 (SIRT1), adiponectin and calprotectin (S100A8/A9) are characterized as factors able to modulate either the NF-κB signaling pathway or toll-like receptor 4 (TLR-4) (6-9). Furthermore, they are considered to be important elements for the molecular pathogenesis of atherosclerosis (4)(5)(6)10,11). SIRT1 is highly expressed in endothelial cells where it controls angiogenesis through a broad variety of transcriptional regulators, including p53, fork-head box O (FoxO), NF-κB, promyelocytic leukemia protein and activated receptor-γ.…”

Section: Introductionmentioning

confidence: 99%

Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and VSMCs contractility in a rat model

Wiciński

Malinowski

Węclewicz

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) is a natural, non-flavonoid polyphenol that exerts protective properties against atherosclerosis-associated endothelial dysfunction and senescence. The present study aimed to assess the influence of resveratrol on vascular contractility and molecular factors including sirtuin-1 (SIRT1), adiponectin and calprotectin (S100A8/A9) that are considered to be important elements of atherogenesis. A total of 17 male rats were divided into a control and treatment group and administered resveratrol or a placebo. Pharmacometrics were performed on an isolated and perfused tail artery. Serum SIRT1, adiponectin and S100A8/A9 levels were quantified using an ELISA assay. The level of SIRT1 in the control and treatment groups at time 0 was 4.26 and 4.45 ng/ml, respectively. SIRT1 in the control and treatment groups following 2 weeks of treatment was 4.59 and 6.86 ng/ml, respectively (P<0.05) and following 4 weeks of treatment was 4.15 and 6.38 ng/ml, respectively (P<0.05). The level of adiponectin in the control and treatment groups at time 0 was 1.24 and 1.21 ng/ml, respectively. Following 2 weeks of treatment, the level of adiponectin in the control and treatment groups was 1.22 and 1.2 ng/ml, respectively (P>0.05) and following 4 weeks of treatment was 1.26 and 1.58 ng/ml, respectively (P<0.05). The S100A8/A9 level in control and treatment groups at time 0 was 0.39 and 0.33 ng/ml, respectively. The level of S100A8/A9 in control and treatment groups following 2 weeks of treatment was 0.37 and 0.35 ng/ml, respectively (P>0.05) and following 4 weeks of treatment was 0.34 and 0.32 ng/ml, respectively (P>0.05). EC 50 values obtained for phenylephrine in resveratrol-pretreated arteries were significantly higher than controls in the presence and absence of A7-hydrochloride (P<0.05). The results of the present study indicate a significant increase in the concentration of SIRT1 and adiponectin in the resveratrol-pretreated group (P<0.05). S100A8/A9 serum concentrations remained unchanged. Reactivity of resistant arteries was significantly reduced for resveratrol-pretreated vessels and this effect was partially independent of phosphodiesterase (PDE1). Additionally, there was a synergistic interaction observed between resveratrol and the PDE1 inhibitor.

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Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes

Abstract: In ACS, MRP8/14 is markedly expressed at the site of coronary occlusion by invading phagocytes. The occurrence of elevated MRP8/14 in the systemic circulation prior to markers of myocardial necrosis makes it a prime candidate for the detection of unstable plaques and management of ACS.

Cited by 186 publications

References 33 publications

Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction

Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction

Upregulated expression of S100A8 in mice brain after focal cerebral ischemia reperfusion

Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and VSMCs contractility in a rat model

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