Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial

Abstract

Background-Using a transcriptional profiling approach, we recently identified myeloid-related protein-8/14 (MRP-8/14) to be expressed by platelets during acute MI. Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals, but have not been assessed with respect to prognosis in patients with ACS.

S100A12 as a Marker to Predict Cardiovascular Events in Patients With Chronic Coronary Artery Disease

“…24 The S100A8/9 heterodimer, another S100A protein, has been associated with an increased risk of cardiovascular events in a case-control study using patients enrolled in the PROVEIT-TIMI22 trial. 25 In the present study, S100A12 was a significant predictor of MACE in patients with stable CAD. In particular, S100A12 was a predictor for the occurrence of CHF.…”

Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction

“…The prognostic value of MRP-8/ 14 has not yet been studied prospectively. A case-control study among 237 patients enrolled in the PROVE IT TIMI (Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction 22) trial showed an increased risk of recurrent cardiovascular events and death with increasing quartiles of MRP-8/14 after adjustment for standard risk factors and CRP during a follow-up of 24 months (14 ).…”

“…A case-control study among 237 patients enrolled in the PROVE IT TIMI (Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction 22) trial showed an increased risk of recurrent cardiovascular events and death with increasing quartiles of MRP-8/14 after adjustment for standard risk factors and CRP during a follow-up of 24 months (14 ). In our study, the prognostic accuracy of MRP-8/14 for the prediction of all-cause death was modest (AUC 0.70) and also remained significant after multivariable adjustment.…”

“…Pilot studies suggested a possible prognostic role for MRP-8/14 in ACS patients (13,14 ). Pregnancy-associated plasma protein A (PAPP-A) is a protease mainly produced by the placenta during pregnancy, but also by fibroblasts, osteoblasts, and vascular smooth muscle cells.…”

Endothelial Dysfunction in Children Without Hypertension

“…34,35 As a corollary to these observations, MRP8/14 is linked to atherosclerosis and serves as a useful biomarker of cardiovascular disease. 36,37 Hence, assays were performed for MRP8/14 using commercial enzyme-linked immunosorbent assay kits (ALPCO Diagnostics and R&D Systems, respectively). MRP8/14 has a sensitivity of 0.4 m g/mL and 0.15 pg/mL, respectively.…”