Abstract:Background
Phosphatase and tensin homolog deleted on chromosome 10(PTEN) signaling has been known to play a critical role in maintaining cellular and tissue homeostasis, which also has an essential role in the inflammatory response. However, it remains unidentified whether and how the myeloid PTEN may govern the innate immune signaling stimulator of interferon genes (STING) mediated inflammation and hepatocyte necroptosis in APAP-induced liver injury (AILI).
Methods
Myeloid-specific PTEN knockout (PTENM−KO) an… Show more
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