Myeloid leukaemia frequency after protracted exposure to ionizing radiation: Experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with X-rays

Mole, R.H.; Major, I. R.

doi:10.1016/0145-2126(83)90020-6

Cited by 22 publications

(10 citation statements)

References 8 publications

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“…For exposures protracted over several weeks the dose response for leukaemia is very similar after part-body X-ray therapy of human subjects with ankylosing spondylitis (Smith & Doll, 1982) and after whole-body y-ray irradiation of male CBA/H mice (Mole & Major 1983) but is quite unlike that shown in Figure 2. In both these cases the dose response for protracted exposure is very flat and comparatively little dependent on dose.…”

Section: For Induction Of Myeloid Leukaemia In Vivo Al/a2mentioning

confidence: 80%

“…Its scientific basis was not mere empiricism but an assumed analogy between induction of malignant disease and of genetic mutation. This assumption of linearity for radiation leukaemogenesis can now be checked by direct experiment since it has proved possible to induce acute myeloid leukaemia (AML) systematically in an experimental animal by a variety of ionizing radiations, X-rays (Major & Mole 1978, Mole & Meldrum 1981, y-rays (Mole & Major 1983) and fission neutrons (Mole & Davids 1982). The induction process for X-rays is found to increase not linearly but according to the square of the radiation dose.…”

mentioning

confidence: 99%

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The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice

Mole¹,

Papworth²,

Corp³

1983

Br J Cancer

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Section: For Induction Of Myeloid Leukaemia In Vivo Al/a2mentioning

confidence: 80%

mentioning

confidence: 99%

The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice

Mole¹,

Papworth²,

Corp³

1983

Br J Cancer

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“…The dose-response curve of leukemia induction is curvilinear, implying a threshold dose as in the models previously discussed. The fact that leukemia is rarely observed in cases with high exposure correlates with human epidemiological data [71,72]. …”

Section: Reviewmentioning

confidence: 66%

Radiation-induced myeloid leukemia in murine models

2014

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The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost. As this number increases, so too does the incidence of secondary, radiation-induced neoplasias, creating a need for therapeutic agents targeted specifically towards incidence reduction and treatment of these cancers. Development and efficacy testing of these agents requires not only extensive in vitro testing but also a set of reliable animal models to accurately recreate the complex situations of radiation-induced carcinogenesis. As radiation-induced leukemic progression often involves genomic changes such as rearrangements, deletions, and changes in methylation, the laboratory mouse Mus musculus, with its fully sequenced genome, is a powerful tool in cancer research. This fact, combined with the molecular and physiological similarities it shares with man and its small size and high rate of breeding in captivity, makes it the most relevant model to use in radiation-induced leukemia research. In this work, we review relevant M. musculus inbred and F1 hybrid animal models, as well as methods of induction of radiation-induced myeloid leukemia. Associated molecular pathologies are also included.

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“…Infiltration of the sternal bone marrow, liver, and spleen are observed and serve as diagnostic endpoints [32,33]. As previously mentioned, the dose-response curve is curvilinear, implying a threshold dose similar to that of man—leukemia is rarely observed in cases with high exposure [70,71]. …”

Section: Resultsmentioning

confidence: 99%

Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review

Rivina

Schiestl

2012

IJERPH

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As the number of cancer survivors treated with radiation as a part of their therapy regimen is constantly increasing, so is concern about radiation-induced cancers. This increases the need for therapeutic and mitigating agents against secondary neoplasias. Development and efficacy testing of these agents requires not only extensive in vitro assessment, but also a set of reliable animal models of radiation-induced carcinogenesis. The laboratory mouse (Mus musculus) remains one of the best animal model systems for cancer research due to its molecular and physiological similarities to man, small size, ease of breeding in captivity and a fully sequenced genome. This work reviews relevant M. musculus inbred and F1 hybrid animal models and methodologies of induction of radiation-induced leukemia, thymic lymphoma, breast, and lung cancer in these models. Where available, the associated molecular pathologies are also included.

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Myeloid leukaemia frequency after protracted exposure to ionizing radiation: Experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with X-rays

Cited by 22 publications

References 8 publications

The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice

The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice

Radiation-induced myeloid leukemia in murine models

Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review

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