Myeloid-derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders

Barnie, Prince Amoah; Zhang, Pan; Lv, Hongxiang; Wang, Dan; Su, Xiaolian; Su, Zhaoliang; Xu, Huaxi

doi:10.3892/etm.2016.4018

Cited by 15 publications

(15 citation statements)

References 128 publications

(106 reference statements)

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“…Many studies have demonstrated that MDSCs are significantly increased in malignancies, autoimmune disease and viral infectious disease . Khaled et al found that G‐MDSCs, but not M‐MDSCs, were significantly increased in circulation and showed increased tumour infiltration in pancreatic cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Polarization of granulocytic myeloid‐derived suppressor cells by hepatitis C core protein is mediated via IL‐10/STAT3 signalling

Wang

Yü

et al. 2018

Journal of Viral Hepatitis

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Summary Myeloid‐derived suppressor cells (MDSCs) have been described as suppressors of T‐cell function in many malignancies. Impaired T‐cell responses have been observed in patients with chronic hepatitis C virus infection (CHC), which is reportedly associated with the establishment of persistent HCV infection. Therefore, we hypothesized that MDSCs also play a role in chronic HCV infection. MDSCs in the peripheral blood of 206 patients with CHC and 20 healthy donors were analyzed by flow cytometry. Peripheral blood mononuclear cells (PBMCs) of healthy donors cultured with hepatitis C virus core protein (HCVc) were stimulated with or without interleukin 10 (IL‐10). Compared to healthy donors and certain CHC patients with sustained viral response (SVR), CHC patients without SVR presented with a dramatic elevation of G‐MDSCs with the HLA‐DR−/lowCD33+CD14−CD11b+ phenotype in peripheral blood. The frequency of G‐MDSCs in CHC patients was positively correlated with serum HCVc, and G‐MDSCs were induced from healthy PBMCs by adding exogenous HCVc. Furthermore, we revealed a potential mechanism by which HCVc mediates G‐MDSC polarization; activation of ERK1/2 resulting in IL‐10 production and IL‐10‐activated STAT3 signalling. Finally, we confirmed that HCVc‐induced G‐MDSCs suppress the proliferation and production of IFN‐γ in autologous T‐cells. We also found that the frequency of G‐MDSCs in serum was associated with CHC prognosis. HCVc maintains immunosuppression by promoting IL‐10/STAT3‐dependent differentiation of G‐MDSCs from PBMCs, resulting in the impaired functioning of T‐cells. G‐MDSCs may thus be a promising biomarker for predicting prognosis of CHC patients.

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Section: Discussionmentioning

confidence: 99%

Polarization of granulocytic myeloid‐derived suppressor cells by hepatitis C core protein is mediated via IL‐10/STAT3 signalling

Wang

Yü

et al. 2018

Journal of Viral Hepatitis

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“…MDSCs have been shown to expand systemically in various pathologies such as infection [89,90], sepsis [91], and autoimmune disorders [92]. All the major cytokines that are involved in the normal hematopoiesis and proliferation of MDSCs, such as macrophage colony stimulating factor and granulocyte macrophage colony stimulating factor (GM-CSF), are highly expressed in GBM [93].…”

Section: Mdscs In Glioma Progressionmentioning

confidence: 99%

“…Furthermore, L-arginine depletion by Arg1 triggers the production of ROS through iNOS. Several tumor-derived growth factors, such as TGF-β, IL-6, IL-10, and GM-CSF, can increase the production of ROS [92].…”

Section: Mdsc-mediated Immunosuppression and Therapy Resistance In Glmentioning

confidence: 99%

Role of Neutrophils and Myeloid-Derived Suppressor Cells in Glioma Progression and Treatment Resistance

Khan

Mittal

McGee

et al. 2020

IJMS

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Recent efforts in brain tumor research have been directed towards the modulation of the immune system for therapeutic interventions. Several human cancers, including gliomas, are infiltrated with immune cell types—including neutrophils and myeloid-derived suppressor cells—that contribute to tumor progression, invasiveness, and treatment resistance. The role of tumor-associated neutrophils and myeloid-derived suppressor cells in cancer biology remains elusive, as these cells can exert a multitude of pro-tumor and antitumor effects. In this review, we provide the current understanding and novel insights on the role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance, as well as the mechanisms of pleiotropic behaviors in these cells during disease progression, with an emphasis on possible strategies to reprogram these cells towards their antitumor actions.

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“…The studies in mice show that MDSCs can increase the generation of Treg through a TGF‐β1‐dependent mechanism, while M‐MDSCs induce antigen‐pulsed Treg by producing NO . Besides, it suggests that CD40/CD40L may have a critical role in inducing Treg, because M‐MDSCs from CD40‐deficient mice cannot promote the proliferation of Treg cells …”

Section: Main Functional Characteristics Of Mdscsmentioning

confidence: 99%

Myeloid‐derived suppressor cells: Roles in the tumor microenvironment and tumor radiotherapy

Yin

Wang

et al. 2018

Intl Journal of Cancer

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Cancer progression is closely related to the tumor microenvironment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, signaling molecules and the extracellular matrix. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can impact the growth and evolution of cancerous cells. One of major cell components in the tumor microenvironment is myeloid-derived suppressor cells (MDSCs), which promote tumor growth and metastasis directly or indirectly by recognizing other immune cells, producing cytokines and exerting their immunosuppression functions. MDSCs have emerged as major regulators of immune responses in cancer and key targets for treating cancer. There are many limitations and side-effect in approaches of conventional cancer therapy, including radiotherapy. It has grown up to be a burgeoning field that a combination of radiotherapy and immunotherapy applied to cancer therapy. Therefore, it is fundamental to explore the immune mechanism in the process of cancer treatment. Here, we reviewed the recent progress of MDSCs in roles of the tumor microenvironment and tumor radiotherapy.

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Myeloid-derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders

Cited by 15 publications

References 128 publications

Polarization of granulocytic myeloid‐derived suppressor cells by hepatitis C core protein is mediated via IL‐10/STAT3 signalling

Polarization of granulocytic myeloid‐derived suppressor cells by hepatitis C core protein is mediated via IL‐10/STAT3 signalling

Role of Neutrophils and Myeloid-Derived Suppressor Cells in Glioma Progression and Treatment Resistance

Myeloid‐derived suppressor cells: Roles in the tumor microenvironment and tumor radiotherapy

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