Myeloid derived suppressor cells and their role in tolerance induction in cancer

Fujimura, Taku; Mahnke, Karsten; Enk, Alexander H.

doi:10.1016/j.jdermsci.2010.05.001

Cited by 79 publications

(94 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TAMs and circulating immature myeloid cells, so-called myeloid-derived suppressor cells (MDSCs), play crucial roles in maintaining the tumor microenvironment together with Tregs (16)(17)(18)(19)(20). In the differentiation cascade of myeloid cells in the tumor-bearing host (21), TAMs are derived from Ly6C + monocytes (monocytic MDSCs) in the blood (21).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of TAMs are alternatively activated M2 macrophages, which represent the main population of inflammatory cells in solid tumors (21)(22)(23)(24). Since some populations of TAMs are derived from MDSCs, the mechanisms of suppressive activities of TAMs are similar to those of MDSCs (16,17,21,22,25). For instance, the ANTICANCER RESEARCH 37: 3461-3471 (2017) 3466 suppressive function of TAMs and MDSCs is partly mediated by the metabolism of L-arginine, which is determined by the expression of high levels of arginase 1 and inducible nitric oxide synthase, both of which inhibit T cell proliferation (16,17,21,22,25).…”

Section: Discussionmentioning

confidence: 99%

“…Since some populations of TAMs are derived from MDSCs, the mechanisms of suppressive activities of TAMs are similar to those of MDSCs (16,17,21,22,25). For instance, the ANTICANCER RESEARCH 37: 3461-3471 (2017) 3466 suppressive function of TAMs and MDSCs is partly mediated by the metabolism of L-arginine, which is determined by the expression of high levels of arginase 1 and inducible nitric oxide synthase, both of which inhibit T cell proliferation (16,17,21,22,25). In addition, both TAMs and MDSCs produce Treg-related chemokines to recruit Tregs to the tumor microenvironment (16,17,21,22,(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

“…For instance, the ANTICANCER RESEARCH 37: 3461-3471 (2017) 3466 suppressive function of TAMs and MDSCs is partly mediated by the metabolism of L-arginine, which is determined by the expression of high levels of arginase 1 and inducible nitric oxide synthase, both of which inhibit T cell proliferation (16,17,21,22,25). In addition, both TAMs and MDSCs produce Treg-related chemokines to recruit Tregs to the tumor microenvironment (16,17,21,22,(25)(26)(27). Moreover, TAMs and MDSCs express immune checkpoint molecules, such as PD-L1 and B7-1, to suppress the activities of effector memory T cells in the tumor (15,25).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas

Furudate

Fujimura

Kambayashi

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas

Furudate

Fujimura

Kambayashi

et al. 2017

View full text Add to dashboard Cite

show abstract

“…TAMs in murine and human melanoma express high levels of PD-L1, which promotes an immunosuppressive microenvi-ronment. [10][11][12][13] Together with Tregs, immunosuppressive TAMs promote an immunosuppressive environment in the tumorbearing host. 10,12,[15][16][17] Alternatively activated M2 macrophages represent the majority of TAMs, and the main population of inflammatory cells in solid tumors.…”

Section: Ifn-b Inhibits the Growth Of Melanoma Cells And Induces Crosmentioning

confidence: 99%

Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages

et al. 2015

Self Cite

View full text Add to dashboard Cite

These authors contributed equally to this work. Keywords: IFN-b, in-transit melanoma, PD-1, regulatory T cells, tumor-associated macrophagesAn imbalance of immunosuppressive cells and cytotoxic cells plays an important role in the tumor-bearing host. Together with regulatory T cells (Tregs), tumor-associated macrophages (TAMs) play roles in maintaining the tumor microenvironment. Since interferon beta (IFN-b) has been clinically used for the treatment of malignant melanoma, we investigated the immunomodulatory effect of IFN-b during melanoma growth to elucidate the effects of IFN-b on the tumor microenvironment by using the B16F10 melanoma model. Peritumorally administered IFN-b significantly decreased the mRNA expression and production of Th2-related chemokines, which suppressed the recruitment of Tregs in B16F10 melanoma. Since the administration of IFN-b augments the expression of PD-1 on TILs, the co-administration of anti-PD-1 Ab augmented the therapeutic effect of IFN-b for the treatment of B16F10 melanoma. Moreover, in parallel with the mouse model, in the human system, IFN-b decreased the production of Th2-related chemokines and augmented the production of Th1-related chemokines from monocyte-derived M2 macrophages. Since these immunomodulatory effects of IFN-b on macrophages were also observed in the lesional skin of human in-transit melanoma, our present data suggest one of the possible immunomodulatory effects of IFN-b and support the possibility of IFN-b in combination with anti-PD-1 Ab for the treatment of melanoma.

show abstract

Myeloid‐derived suppressor cells: Important contributors to tumor progression and metastasis

Safarzadeh

Orangi

Mohammadi

et al. 2017

Journal Cellular Physiology

148

113

View full text Add to dashboard Cite

Myeloid-derived suppressor cells (MDSCs) are traditionally considered among the major components of the immunosuppressive tumor microenvironment (TME). However, there is currently increasing evidence indicating that MDSCs in addition to suppression of immune surveillance is also involved in an array of non-immunological functions like augmenting metastatic potential of tumor cells. Indeed, MDSCs can promote metastasis in animal models and cancer patients through promoting premetastatic niche formation, tumor angiogenesis and invasion. Moreover, MDSC frequency and function have been associated with progressive disease and correlated with clinical outcome. This review will summarize and discusses the data demonstrating the role for MDSCs in tumor metastasis.

show abstract

Myeloid derived suppressor cells and their role in tolerance induction in cancer

Cited by 79 publications

References 49 publications

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas

Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages

Myeloid‐derived suppressor cells: Important contributors to tumor progression and metastasis

Contact Info

Product

Resources

About