“…Studies have shown that GSDMD deletion or inhibition notably decreases pyroptosis and remarkably protect mice from sepsis, which is a fatal condition requiring urgent medical solutions ( 12 – 14 ). In addition, GSDMD acts as an effector of inflammasome signaling and is implicated in several human diseases, including nonalcoholic steatohepatitis ( 15 ), cardiovascular disease ( 16 ), inflammatory bowel disease ( 17 ), type II diabetes ( 17 , 18 ), rheumatoid arthritis ( 19 ), cancer ( 20 , 21 ), and Alzheimer’s disease ( 22 ). Consequently, on account of the crucial function of GSDMD in pyroptosis, it has emerged as an ideal and attracting target for therapeutic intervention of inflammasome-driven diseases.…”