Myelodysplastic syndromes del(5q): Pathogenesis and its therapeutic implications
Antonella Bruzzese,
Enrica Antonia Martino,
Francesco Mendicino
et al.
Abstract:Myelodysplastic syndromes (MDS) encompass a heterogeneous set of acquired bone marrow neoplastic disorders characterized by ineffective hematopoiesis within one or more bone marrow lineages. Nearly half of MDS patients carry cytogenetic alterations, with del(5q) being the most prevalent. Since its first description, del(5q) was consistently correlated with a typical clinical phenotype marked by anemia, thrombocytosis, and a low risk of evolving into acute leukemia. Presently, the World Health Organization (WHO… Show more
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