Myelodysplastic Syndrome of del 20q with Plasma Cell Dysplasia

Saito, Nagahito; Higashiura, Katsuhiro; Ehata, Kazunori; Kurosawa, Shinji; Honma, Kenta; Abe, Masayuki; Kimura, Akihiko; Suzuki, Motofumi; Nakamura, Shigeo; Shiku, Hiroshi; Ooi, Hong Kean

doi:10.3960/jslrt.51.141

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…Interestingly, this case also showed morphological abnormality in three cellular lineages coupled with chromosomal abnormality of 45 (X, -Y), and the presence of plural M-proteins such as IgGκ and IgGλ. Previously, we have reported an MDS case with B-cell abnormality [15]. Since the leukemic cells in our present case were also positive for CD10, a marker which is also detected on immature B-cells, it is rational to implicate that certain kind of MDS cases might be related to B-cell disorder.…”

Section: Discussionsupporting

confidence: 61%

“…Plural M-proteins observed in our elderly case with non-B cell leukemia would probably have come from his high age. The large lymphocytic cells with nuclear pockets seen in the bone marrow smears would not be capable of differentiating into leukemia-related cells associated with MDS, despite that abnormal cells with nuclear pockets had been observed in MDS-bone marrow cells in certain instances [15].…”

Section: Discussionmentioning

confidence: 94%

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T-Cell Prolymphocytic Leukemia Accompanied by Plural M-Proteins with Myelodysplastic Syndroxme in a Nonagenarian

Saito¹,

Higashiura²,

Honma³

et al. 2012

J Clin Case Rep

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T-cell Pro-Lymphocytic Leukemia (T-PLL) is a rare disease caused by malignancy of mature post-thymic T-cell. Myelodysplastic Syndrome (MDS) is caused by abnormal differentiation of myeloid lineage cells resulting in myeloid leukemia. Both of these hematological disorders are frequently diagnosed in elderly persons. Myeloid lineage is believed to be situated at the position far from lymphoid one as it is regarded on a tree diagram about the blood cell maturation. We reported herein a rare case of T-PLL accompanied by plural M-proteins with MDS a nonagenarian. The 96 years old patient was admitted to our hospital because of lymphocytosis and abnormal lymphocytes. From the bone marrow aspirate, biopsy and hematological findings, abnormalities were observed in cells of three different lineages, namely, (i) neutrophils with hypersegmented-nuclei (ii) erythroblasts with nuclear division, large platelets and megakaryoblastic cells, and (iii) reticulum cells with phagocytosed iron in their cytoplasm. Lymphocytes showed CD3 (+), CD4 (±), CD5 (+), CD8 (+), CD10 (+), CD56 (-) and CD57 (-). Mast cells and large lymphocytic cells with nuclear pockets were also seen. Anti-HTLV-1 antibody was negative. Soluble IL-2 receptor was significantly elevated to 7910 U/ml. Both IgGλ and IgGκM-protein were detected. No Bence-Jones protein was detected in the urine. Chromosomal abnormality of 45 (X, 0) or loss of Y chromosome was also demonstrated. Due to his high age, it was difficult to classify his condition according to the conventional classification. Thus, what we had experienced is truly a rare case that coincidentally showed T-PLL and MDS with plural M-proteins.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 94%

T-Cell Prolymphocytic Leukemia Accompanied by Plural M-Proteins with Myelodysplastic Syndroxme in a Nonagenarian

Saito¹,

Higashiura²,

Honma³

et al. 2012

J Clin Case Rep

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“…Intracytoplasmic-iron demonstrated the viability of macrophage in heme recycling system [16] and can induce immunological abnormality in the host, which can lead to infection [17] as the macrophages and erythroid cells making physical contact can exert influences on each other [18]. Degraded immunoglobulin and/or auto-antibodies in serum has been observed in some MDS patients [10,19]. Immunoglobulin was found to be diminished in five of our six cases, indicating the occurrence of immunological abnormality.…”

Section: Discussionmentioning

confidence: 59%

“…The remaining three other cases showed abnormalities of soluble-IL2 receptor, ß2microglobulin, immunoglobulin or Coombs-test. From our previous reports [10,19], immunological abnormalities such as positive ANA were not the result of past infection by B19V but might be the hallmarks of compromised host such as MDS. Each of our cases showed clinical symptoms of immunological abnormality at the time of admission.…”

Section: Discussionmentioning

confidence: 87%

Hemolysis of Some Elderly MDS Cases Might be Related to Prolonged Parvovirus B19 Infection

Saito¹

2015

Int J Immunol Immunother

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Myelodysplastic syndrome (MDS) is a hematological disorder due to abnormal maturation and differentiation of stem cells. It is clinically manifested as cytopenia and commonly seen in elderly persons. Some MDS cases are known to show longitudinal hemolysis, which is attributed to various factors. Human parvovirus B19 (B19V) had been found in blood for transfusion and is also capable of infecting immature erythroid cells. In our study, we made a thorough review of six elderly MDS cases with slight immunological abnormality and longitudinal hemolysis to elucidate their association with B19V infection. Five of the six cases had received blood transfusion prior to coming to the hematological section of our hospital. All the 6 cases were positive for anti-B19V IgG antibody in their sera. In the bone marrow of all the cases, macrophages were observed to be directly in contact with the erythroid islands showing hypocellular marrow by biopsy. Based on the data of these cases, we proposed that hemolysis in elderly MDS patient with immunological abnormality might be related to B19V infection.

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Myelodysplastic Syndrome of del 20q with Plasma Cell Dysplasia

Cited by 2 publications

References 22 publications

T-Cell Prolymphocytic Leukemia Accompanied by Plural M-Proteins with Myelodysplastic Syndroxme in a Nonagenarian

T-Cell Prolymphocytic Leukemia Accompanied by Plural M-Proteins with Myelodysplastic Syndroxme in a Nonagenarian

Hemolysis of Some Elderly MDS Cases Might be Related to Prolonged Parvovirus B19 Infection

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