Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome

Merrill, Andrea; Smith, Hedy

doi:10.1155/2011/560106

Cited by 15 publications

(18 citation statements)

References 18 publications

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“…Two further cases of AFOP with MDS have been reported (14,15), one of which presented the above-mentioned chromosomal abnormality. Both cases responded favorably to corticosteroids and demonstrated improvement in the respiratory symptoms (15).…”

Section: Discussionmentioning

confidence: 95%

Acute Fibrinous and Organizing Pneumonia with Myelodysplastic Syndrome: Corticosteroid Monotherapy Led to Successful Ventilator Weaning

et al. 2016

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A 62-year-old man with myelodysplastic syndrome (MDS) presented to our hospital with a high fever. Although treatment with broad-spectrum antibiotics was initiated, his respiratory status worsened to the point that he required mechanical ventilation. However, he was successfully treated with a corticosteroid without immunosuppression. Sequential transbronchial lung biopsies revealed abundant fibrin exudate in the alveolar spaces, which was subsequently replaced by fibroblasts, showing that acute fibrinous and organizing pneumonia (AFOP) gradually changes into organizing pneumonia. Our case demonstrated both the efficacy of corticosteroid-monotherapy and the histological course of AFOP.

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Section: Discussionmentioning

confidence: 95%

Acute Fibrinous and Organizing Pneumonia with Myelodysplastic Syndrome: Corticosteroid Monotherapy Led to Successful Ventilator Weaning

et al. 2016

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“…According to the previous reports, most of the patients with AFOP had known secondary causes, including lung transplantation, infections including H1N1 virus, Chlamydia pneumonia, HIV, malignant hematological diseases, and connective tissue diseases. [ 7 13 14 15 16 ] However, as shown in Beasley's report, most of their patients were diagnosed with AFOP without any secondary cause. Beasley's report was a retrospective study which was similar to the present study and had a limitation on exploring the secondary causes.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiological Profile of Acute Fibrinous and Organizing Pneumonia

Dai

Shen

et al. 2015

Chinese Medical Journal

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Background:Acute fibrinous and organizing pneumonia (AFOP) is a unique pathological entity with intra-alveolar fibrin in the form of “fibrin balls” and organizing pneumonia. It was divided into rare idiopathic interstitial pneumonia according to the classification notified by American Thoracic Society/European Respiratory Society in 2013. As a rare pathological entity, it is still not well known and recognized by clinicians. We reviewed the clinical features of 20 patients with AFOP diagnosed in a teaching hospital.Methods:The medical records of 20 patients with biopsy-proven diagnosis of AFOP were retrospectively reviewed. The patients’ symptoms, duration of the disease, comorbidities, clinical laboratory data, pulmonary function testing, radiographic studies, and the response to treatment were extracted and analyzed.Results:Fever was the most common symptom and was manifested in 90% of AFOP patients. For clinical laboratory findings, systematic inflammatory indicators, including C-reactive protein and erythrocyte sedimentation rate, were significantly higher than normal in AFOP patients. In accordance with this increased indicators, injured liver functions were common in AFOP patients. Inversely, AFOP patients had worse clinical conditions including anemia and hypoalbuminemia. For pulmonary function testing, AFOP patients showed the pattern of restrictive mixed with obstructive ventilation dysfunction. For high-resolution computerized tomography (HRCT) findings, the most common pattern for AFOP patients was lobar consolidation which was very similar to pneumonia. However, unlike pneumonia, AFOP patients responded well to glucocorticoids.Conclusion:Patients with AFOP manifest as acute inflammatory-like clinical laboratory parameters and lobar consolidation on HRCT, but respond well to steroid.

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“…Because the clinical manifestations are nonspecific, the pathogenesis of AFOP is not fully understood. It can be idiopathic or associated with a wide spectrum of clinical conditions, such as connective tissue diseases[4,6,7], bacterial infections or viral infections[3,8], specific etiologic agent like Chlamydophila pneumoniae[9], chronic renal insufficiency[10], drug reaction or drug-induced toxicity[11], hematologic disease[12,13], hematopoietic stem cell transplantation[14], and occupational or environmental exposures[1].…”

Section: Discussionmentioning

confidence: 99%

Successful steroid treatment for acute fibrinous and organizing pneumonia: A case report

Ning

Ding

et al. 2018

WJCC

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BACKGROUNDSince the acute fibrinous and organizing pneumonia (AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no standard therapy for this disease and the treatment methods remain controversial. Both steroid and immunosuppressive agents, such as cyclophosphamide or mycophenolate mofetil, have been reported to be effective in some studies, but with many side effects, especially in patients of advanced age.CASE SUMMARYWe herein report an 81-year-old female patient who was admitted to our hospital due to dry cough, and breathlessness for 1 mo. She was treated with broad-spectrum antibiotics and anti-fungal therapy, but without improvement in both symptoms and radiological findings, and her respiratory status worsened, and she required bed rest almost the whole day. Computed tomography-guided percutaneous needle lung biopsy was performed and histopathology examination confirmed the diagnosis of AFOP. She was then successfully treated with a steroid monotherapy, which resulted in a satisfactory clinical outcome without serious complications.CONCLUSIONWe conclude that complete remission of AFOP can be achieved by steroid monotherapy in patients of advanced age.

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Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome

Cited by 15 publications

References 18 publications

Acute Fibrinous and Organizing Pneumonia with Myelodysplastic Syndrome: Corticosteroid Monotherapy Led to Successful Ventilator Weaning

Acute Fibrinous and Organizing Pneumonia with Myelodysplastic Syndrome: Corticosteroid Monotherapy Led to Successful Ventilator Weaning

Clinical and Radiological Profile of Acute Fibrinous and Organizing Pneumonia

Successful steroid treatment for acute fibrinous and organizing pneumonia: A case report

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