Myelodysplastic Syndrome: An Egyptian Experience

Husseiny, Noha M. El

doi:10.4172/2155-9864.1000121

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…In the present study, male to female ratio was 1.4:1, which is consistent with reports from European and Asian regions [17]. The mean age was 56 years and the median was 57.5 years, which was in line with the mean age 55 years that was previously reported in Egyptian patients with MDS [18], and comparable with median age 60 years in Tunisian [19] and 59 years in Pakistani patients [17]. However, the age was lower (67 years) than that recorded in USA patients [20], and higher (45 years) than that reported in Chinese [21] and in Indian (42 years) patients [22].…”

Section: Discussionsupporting

confidence: 93%

“…According to WHO 2016, MDS-MLD in our study was the most frequent reported primary MDS subtype (38%) followed by MDS-SLD (RA) (22%) which was in agreement with previous reports from Egyptian MDS patients [18] while MDS-MLD was the most frequent subtype among German patients (27.6%) followed by MDS-EB-II (20.6%) [24], in US patients (32.2%) followed by MDS-EB-I (19.7%) [20], in Chinese patients (44%) followed by MDS-EB-I (19%) [21], and in Pakistani patients (52.1%) followed by MDS-EB-II (23.9%) [17]. This finding was in contrast with Indian primary MDS patients as MDS-SLD was the most frequent MDS subtype (37.5%) followed by MDS-EB-I (17.5%) [22].…”

Section: Discussionsupporting

confidence: 92%

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Cytogenetic Features in Primary Myelodysplastic Syndrome Egyptian Patients

Elnahass¹,

Talaat

Elreafey³

2019

Clinical Lymphoma Myeloma and Leukemia

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Karyotype is the most important diagnostic and prognostic parameter in myelodysplastic syndromes (MDS) and is abnormal in approximately 50% of patients. We emphasized the importance of chromosomal analysis and reported the most frequent cytogenetic abnormalities in 50 MDS (29 males (58%) and 21 females (42%), median age: 57.5 years) Egyptian patients using conventional banding analysis (CBA). Karyotype description was conducted according to the International System for Human Cytogenetic Nomenclature (ISCN, 2013). Patients were diagnosed based on complete history, bone marrow (BM) aspirate, peripheral blood (PBL) examination, and Iron stain. MDS with multilineage dysplasia (MDS-MLD) was the most frequently encountered subtype; 19/50 (38%) followed by MDS with single lineage dysplasia (MDS-SLD); 11/50 (22%). 27/50 patients (54%) showed a normal karyotype while 23 patients (46%) showed clonal nonrandom chromosomal abnormalities. Most patients with MDS with excess blasts-II (MDS-EB-II) showed abnormal karyotype (3/4; 75%) followed by MDS-EB-I (3/5, 60%) and MDS-MLD (10/19, 53%). Among 50 primary MDS patients; 14/50 (28%) had a single chromosomal abnormality, 3/50 (6%) had double chromosomal abnormality, and 6/50 (12%) had complex karyotype. Male sex was more frequently associated with higher IPSS prognostic risk categories than female gender. The most common single chromosomal abnormalities were À5/del5q; 7/50 (14%) patients followed by À7; 4/50 (8%) patients. +8, del20q and delY were each detected in 1/50 patient (2%). Abnormalities of chromosome 5 (À5/del5q) as a single chromosomal abnormality was the most frequent chromosomal abnormality among Egyptian primary MDS patients followed by complex karyotype. Cytogenetic characteristics of MDS Egyptian patients were similar to North African and European patients. Karyotype offers useful

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Cytogenetic Features in Primary Myelodysplastic Syndrome Egyptian Patients

Elnahass¹,

Talaat

Elreafey³

2019

Clinical Lymphoma Myeloma and Leukemia

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“…According to WHO 2016, MDS-MLD in our study was the most frequent reported primary MDS subtype (38%) followed by MDS-SLD (RA) (22%) which was in agreement with previous reports from Egyptian MDS patients [18] while MDS-MLD was the most frequent subtype among German patients (27.6%) followed by MDS-EB-II (20.6%) [24] , in US patients (32.2%) followed by MDS-EB-I (19.7%) [20] , in Chinese patients (44%) followed by MDS-EB-I (19%) [21] , and in Pakistani patients (52.1%) followed by MDS-EB-II (23.9%) [17] . This finding was in contrast with Indian primary MDS patients as MDS-SLD was the most frequent MDS subtype (37.5%) followed by MDS-EB-I (17.5%) [22] .…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, male to female ratio was 1.4:1, which is consistent with reports from European and Asian regions [17] . The mean age was 56 years and the median was 57.5 years, which was in line with the mean age 55 years that was previously reported in Egyptian patients with MDS [18] , and comparable with median age 60 years in Tunisian [19] and 59 years in Pakistani patients [17] . However, the age was lower (67 years) than that recorded in USA patients [20] , and higher (45 years) than that reported in Chinese [21] and in Indian (42 years) patients [22] .…”

Section: Discussionsupporting

confidence: 90%

Cytogenetic features in primary myelodysplastic syndrome Egyptian patients

Elnahass

Youssif

2018

Journal of Advanced Research

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“…This is therefore likely to represent an epidemiological transition as there was a 24% increase in MDS cases over 14 years, reflecting an ageing population, whose life expectancy has increased from 73 years in 2005 to 76.5 in 2017 [28]. Moreover, the age of our MDS patients is higher than in Tunisia (mean age=55 years) [26], Morocco (mean age=66 tears) [27], Egypt (mean age=55 years) [29] or Pakistan (mean age=58 years) [30], but still lower than in Greece (mean age=73,1 years) [25] or in Europe (mean age=71 years) [31][32]. In our study, a slight female predominance (ratio F/M=1.11) was found, particularly in the age group between 65 and 70 years (ratio F/M=1,17), as well as in Egypt (ratio=1,3), which differs from the slight male predominance generally reported in western countries.…”

Section: Figure 2b Overall Survival Stratified By Mds Typementioning

confidence: 99%

Adults Myelodysplastic Syndromes in Algeria: A Study by the Algerian MDS Group

Bekadja,

Fenaux,

Akrouf

et al. 2023

Asian Pac J Cancer Biol

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Introduction: Myelodysplastic syndromes (MDS) are a group of haematological disorders, whose diagnosis is based mainly on cytological studies of blood and marrow cells and cytogenetic analysis. Moreover, national epidemiological data on MDS are very scarce, especially in Maghreb countries where the population is on average younger than in Europe or the USA. The objective of the present study was to describe demographic and clinical features and the overall survival of patients with MDS in Algeria. Materials and Methods: This study is retrospective and national multicenter (n=19 centres), performed between 2014 to 2019. The evaluation was performed using EPI-INFO and SPSS version 21 software. Survival data were calculated using the Kaplan-Meier method and comparison of survival curves using the Log Rank test. Univariate and multivariate analysis of survival was performed using the Cox regression method. The study has been approved by the Ethical and Scientific Council of the participating hospitals. The closing date of the study is 31/12/2019. Results: A total of 670 patients with newly diagnosed MDS have been identified. The average number of new cases was 112/year, with an annual progression rate of 19%. Demographics show a slight female predominance (M/F of 317/353=0, 89; sex ratio F/M=1.11). The median follow-up was 29,3 months (range, 1 to 77 months). The overall median age was 69 years (range 16-96). The crude mean annual incidence rate was 0, 38 per 100,000 inhabitants aged ≥15 years old and it was 0, 17/100,000 in men and 0, 21/100,000 in women. Overall survival was 39 months. According to the IPSS score, the high-risk forms are low and their overall survival was 15 months. The rate of transformation into acute myeloid leukaemia (AML) is 32%. Conclusion: This national epidemiological survey shows an annual progression rate of 19% and an increase in incidence from 0.007/100.000 in 2005 to 0.45/100.000 in 2019.

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Myelodysplastic Syndrome: An Egyptian Experience

Cited by 4 publications

References 23 publications

Cytogenetic Features in Primary Myelodysplastic Syndrome Egyptian Patients

Cytogenetic Features in Primary Myelodysplastic Syndrome Egyptian Patients

Cytogenetic features in primary myelodysplastic syndrome Egyptian patients

Adults Myelodysplastic Syndromes in Algeria: A Study by the Algerian MDS Group

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