Myelodysplasia and autoimmunity

Giannouli, Stavroula; Kanellopoulou, Theoni; Voulgarelis, Michael

doi:10.1097/bor.0b013e32834db4ee

Cited by 30 publications

(22 citation statements)

References 53 publications

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“…Among the hematopoietic neoplasms, MDS has been shown to be the most commonly associated disease with AID [21,27]. Associations between CMML and AID, including pyoderma gangrenosum, vasculitis, idiopathic thrombocytopenia, idiopathic eosinophilia and chronic inflammatory demyelinating polyneuropathy, are not uncommon [18,21,28].…”

Section: Discussionmentioning

confidence: 99%

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A Close Association of Autoimmune-Mediated Processes and Autoimmune Disorders with Chronic Myelomonocytic Leukemia: Observation from a Single Institution

Peker¹,

Padron²,

Bennett

et al. 2014

Acta Haematol

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Chronic myelomonocytic leukemia (CMML), a clonal hematopoietic stem cell disease, may be linked to immune-mediated processes and/or autoimmune disorders (AID), although the exact pathogens are still elusive. We retrospectively analyzed 123 CMML patients in our institution. Twenty-four CMML patients (19.5%) had at least one immune-mediated disorder, most commonly idiopathic thrombocytopenic purpura, gout and psoriasis. Four of these 24 patients (15%) had more than one AID. We found that, in contrast to the general population with a prevalence rate of 3.2-5.2%, newly diagnosed CMML patients demonstrated a high prevalence and variety of immune-mediated processes and/or AID. When we compared the results with those of myelodysplastic syndromes published in the literature, the prevalence of AID in these two groups of patients is similar. Our results also showed that the presence of cytogenetic abnormalities was less in CMML patients with AID (6 of 21; 28.6%) than in those without AID (37 of 94; 39.4%), although there was no statistical significance (p = 0.334). A multicenter large cohort study of CMML with AID is recommended to illustrate the molecular relationship between the two distinct groups. © 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

“…Some cytokine releases and clonal T-LGL/NK cell expansion during an autoimmune process could alter tissue microenvironments [47]. If the process occurred in MDS bone marrow, it would cause gene dysregulation in hematopoietic stem cells [27]. …”

Section: Discussionmentioning

confidence: 99%

A Close Association of Autoimmune-Mediated Processes and Autoimmune Disorders with Chronic Myelomonocytic Leukemia: Observation from a Single Institution

Peker¹,

Padron²,

Bennett

et al. 2014

Acta Haematol

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“…Either way, both AA and MDS have a proportion of patients that have associated with clinical autoimmune phenomena 6,7 in addition to T cellmediated myelosuppression, and cytokine dysregulation in the bone marrow environment. Thus, the link of both disorders to an underlying autoimmune mechanism with an association with other autoimmune manifestations appears to be well established.…”

mentioning

confidence: 99%

STAT3 mutations and persistence of autoimmunity

Schultz

2013

Blood

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“…Nonhematologic autoimmune disorders in MDS were fi rst described by Hamblin [6]. Castro et al reviewed 162 patients with MDS over a 6-month period, among whom rheumatic manifestations such as cutaneous vasculitis, lupus-like syndrome, or neuropathy was observed in 10% of the patients [1].…”

Section: Discussionmentioning

confidence: 99%

Rheumatic manifestations and an epipharyngeal mass accompanied by myelodysplastic syndrome

Inoue

Kano

Ozaki

et al. 2013

Modern Rheumatology

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We herein report two cases of myelodysplastic syndrome with rheumatic manifestations. (Case 1) A 70-year-old man presented with fever, arthritis and bone pain and developed cranial nerve palsy caused by an epipharyngeal mass. Steroid therapy led to a prolonged remission of the febrile condition and mass lesion. (Case 2) An 82-year-old male was treated for intractable polyarthritis and fever with steroid therapy, and serious side effects resulted in lethal pneumonia. We herein describe the entire course of steroid therapy in these two cases. Various rheumatic manifestations in myelodyaplastic syndrome often require empirical steroid therapy. It was effective for the soft tissue mass in Case 1, in which indolent lymphoma could not be denied, and was only partially effective for Case 2 of the febrile and putatively benign conditions, suggesting heterogeneous nature of rheumatic complications in myelodysplastic syndrome.

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Myelodysplasia and autoimmunity

Abstract: The encouraging biological insights into the autoimmune component of MDS pathophysiology can lead to the development of novel forms of treatment for controlling MDS process. MDS with AIMs constitute an ideal model in the investigation of disordered immune function in preleukemic states.

Cited by 30 publications

References 53 publications

A Close Association of Autoimmune-Mediated Processes and Autoimmune Disorders with Chronic Myelomonocytic Leukemia: Observation from a Single Institution

A Close Association of Autoimmune-Mediated Processes and Autoimmune Disorders with Chronic Myelomonocytic Leukemia: Observation from a Single Institution

STAT3 mutations and persistence of autoimmunity

Rheumatic manifestations and an epipharyngeal mass accompanied by myelodysplastic syndrome

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