Myeloblastoma preceding blood and marrow evidence of acute leukemia

Comings, David E.; Fayen, Arthur W.; Carter, Peter

doi:10.1002/1097-0142(196502)18:2<253::aid-cncr2820180218>3.0.co;2-#

Cited by 52 publications

(9 citation statements)

References 11 publications

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“…3 The number of heterozygotes, identified through pedigree studies, agrees with the expected prevalence according to published findings,'0 the number of homozygotes, however, was small. The probability of finding HLA identical (homozygote) family members through pedigree studies is influenced by different factors: the recessive mode of inheritance, the gene prevalence in the population, and number of siblings in the family, etc.…”

supporting

confidence: 86%

Cytogenetic analysis of a granulocytic sarcoma in a patient without systemic leukaemia.

et al. 1991

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Granulocytic sarcoma is a rare complication of leukaemia. Occasionally it presents before the development of systemic leukaemia when diagnosis may be difficult. A case of granulocytic sarcoma occurring in a patient with no overt evidence of leukaemia, but in whom cytogenetic analysis of the bone marrow showed a clonal t(12;13) translocation, is reported. Cytogenetic analysis of tissues in this disease may indicate evidence of systemic disease before overt morphological changes.

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supporting

confidence: 86%

Cytogenetic analysis of a granulocytic sarcoma in a patient without systemic leukaemia.

et al. 1991

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“…In a large series of autopsy cases, the involvement of the myocardium with GS is rare (<1%) 3 , 6 . GS has been noted in two reports to precede the diagnosis of overt bone marrow leukemia, 7,8 however, the incidence of GS is hard to assess in patients with myelogenous leukemia as most tumors are discovered only at autopsy.…”

Section: Discussionmentioning

confidence: 99%

Extensive Neoplastic Cardiac Infiltration in a Patient With Acute Myelogenous Leukemia: Role of Echocardiography

et al. 2003

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We present the case of a 34-year-old man with a history of relapsed acute myelogenous leukemia with extensive metastatic infiltration of the endomyocardium. Transesophageal echocardiography revealed masses within all the cardiac chambers and associated vascular structures. Biopsy of the superior vena cava mass had the histological features of a granulocytic sarcoma (GS, chloroma). Massive involvement of the heart with GS is very rare, and only a few reports have been published in the literature.

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“…The most common sites of occurrence are bone, lymph nodes, and skin (leukemia cutis). Cardiac involvement without marrow involvement is extremely rare [3,4]. We describe a patient with fulminant heart failure who was found at autopsy to have diffuse infiltration of the myocardium with leukemic cells.…”

Section: Introductionmentioning

confidence: 92%

Therapy-related myelodysplastic syndrome presenting as fulminant heart failure secondary to myeloid sarcoma

et al. 2010

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Rapidly progressive heart failure is commonly caused by an extensive myocardial infarction, a mechanical complication of infarction, myocarditis, or acute valvular insufficiency. We present an unusual case that was caused by a diffuse infiltration of the myocardium with leukemic cells (myeloid sarcoma). The patient presented with episodic shortness of breath, he was anemic and thrombocytopenic, and his bone marrow biopsy revealed myelodys-

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Myeloblastoma preceding blood and marrow evidence of acute leukemia

Cited by 52 publications

References 11 publications

Cytogenetic analysis of a granulocytic sarcoma in a patient without systemic leukaemia.

Cytogenetic analysis of a granulocytic sarcoma in a patient without systemic leukaemia.

Extensive Neoplastic Cardiac Infiltration in a Patient With Acute Myelogenous Leukemia: Role of Echocardiography

Therapy-related myelodysplastic syndrome presenting as fulminant heart failure secondary to myeloid sarcoma

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