“…In many of infectious myelitis, it has been observed that major pathologic change occurred in mesodermal structures (blood vessels and meninges) but rarely the cord proper. 6) Infectious microorganisms may produce lesions of the cord indirectly by invading the vessel walls and producing vascular obstruction and circulatory interference with ultimate destruction of the substance of the cord. It is partly, of course, a philosophical question whether it is, in fact, due to the action of an infectious agent on the spinal cord itself, via an undefined hypersensitivity reaction, or by induced vascular lesions, possibly in turn also associated with sensitivity.…”