Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

Macias, Melissa Y.; Lehman, Cheryl T.; Sanger, James R.; Riley, Denise

doi:10.1002/(sici)1097-4598(199812)21:12<1748::aid-mus18>3.0.co;2-k

Cited by 20 publications

(13 citation statements)

References 37 publications

(68 reference statements)

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“…45e47 Some models use more than one nerve of the forelimb, 45e47,53 the hindlimb, 17,21,35,38,42 or both. 33 A neuroma model on the facial nerve has also been described, but it is far less popular. 48 …”

Section: Animal Model Animalsupporting

confidence: 81%

A systematic review of animal models for experimental neuroma

Toia

Giesen

Giovanoli

et al. 2015

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Section: Animal Model Animalsupporting

confidence: 81%

A systematic review of animal models for experimental neuroma

Toia

Giesen

Giovanoli

et al. 2015

Journal of Plastic, Reconstructive & Aesthetic Surgery

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“…The method used allows labeling of ChATϩ myelinated alphamotor and unmyelinated sympathetic cholinergic fibers in peripheral nerves of a variety of animal species (Lago, unpublished observations). The number of ChATϩ motor fibers in control rat sciatic nerves corresponded well with the numbers found under ultrastructural (Schmalbruch, 1986) and in estimates of CE histochemical studies (Macias et al, 1998). Our results indicate that immunohistochemistry against ChAT labels with good resolution motor fibers in normal and regenerated nerves and can be used for the assessment of the amount and the topographical distribution of motor axons regeneration.…”

Section: Motor Axon Regenerationmentioning

confidence: 97%

“…Nevertheless, methodological issues and variability among different combinations of retrotracers have to be taken into account in such studies (Puigdellivol et al, 2002). Using combined CE and CA histochemical staining it has been reported that CAϩ sensory fibers grew earlier than CEϩ motor fibers in the neuroma developed after cutting the sciatic nerve (Macias et al, 1998;Sanger et al, 1991). Intrinsic differences between sensory and motor neurons were corroborated in the median-ulnar nerves where the cell bodies were at similar distances from the injury site and revealed that motor axon lagged behind sensory axon regeneration (Macias et al, 1998).…”

Section: Motor Axon Regenerationmentioning

confidence: 99%

“…In previous works, cholinesterase (CE) and carbonic anhydrase (CA) staining were applied for the study and identification of fascicles containing motor and sensory myelinated axons (Macias et al, 1998;Riley et al, 1988;Sanger et al, 1991). Nevertheless, Kawasaki et al (2000) could identify only 60% of the myelinated sensory fibers and 50% of the myelinated motor fibers in control nerves at the microscopic level compared with the results based on ultraestructural study (Schmalbruch, 1986).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Target Reinnervation and Distribution of Motor Axons in the Injured Rat Sciatic Nerve

Lago

Navarro

2006

Journal of Neurotrauma

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Peripheral nerve injuries are rarely followed by complete return of function. Deficits are particularly important for motor function, resulting in paralysis and muscle atrophy. In different groups, the sciatic nerve was either crushed or transected and repaired by direct suture or by tube repair using silicone or collagen tubes. After 60 days, nerve regeneration was assessed by electrophysiological and functional tests, nerve morphology and immunohistochemistry against choline acetyltransferase (ChAT) for labeling motor axons. Suture and tube repair resulted in similar levels of muscle reinnervation, but significantly lower than after nerve crush. Recovery of walking track pattern was poor in all groups after nerve section. The numbers of regenerated myelinated fibers and of ChAT+ fibers were similar to control values after nerve crush, but increased after section and repair. The normal fascicular architecture and grouping of ChAT+ fibers were maintained after nerve crush, but lost after section and repair, where motor fibers were scattered within small regenerated fascicles throughout the nerve. The loss of fascicular organization was related to the deficient recovery of locomotor function. Thus, labeling of motor axons by ChAT immunohistochemistry provides useful information for the study of the degree and specificity of nerve regeneration.

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“…Carbonic anhydrase (CA) may play an important role in the neurochemical functioning of the membrane potentials of enthesial nerve endings as it does in other sensory systems (23)(24)(25)(26)(27). Numerous CA-positive neurons have been found in the trigeminal and geniculate ganglia as well as in the mescencephalic trigeminal nucleus (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Effects of Topical Brinzolamide on Infantile Nystagmus Syndrome Waveforms: Eyedrops for Nystagmus

Dell’Osso

Hertle

Leigh

et al. 2011

Journal of Neuro-Ophthalmology

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Background: Recent advances in infantile nystagmus syndrome (INS) surgery have uncovered the therapeutic importance of proprioception. In this report, we test the hypothesis that the topical carbonic anhydrase inhibitor (CAI) brinzolamide (Azopt) has beneficial effects on measures of nystagmus foveation quality in a subject with INS. Methods: Eye movement data were taken, using a highspeed digital video recording system, before and after 3 days of the application of topical brinzolamide 3 times daily in each eye. Nystagmus waveforms were analyzed by applying the eXpanded Nystagmus Acuity Function (NAFX) at different gaze angles and determining the longest foveation domain (LFD) and compared to previously published data from the same subject after the use of a systemic CAI, contact lenses, and convergence and to other subjects before and after eye muscle surgery for INS. Results: Topical brinzolamide improved foveation by both a 51.9% increase in the peak value of the NAFX function (from 0.395 to 0.600) and a 50% broadening of the NAFX vs Gaze Angle curve (the LFD increased from 20°to 30°). The improvements in NAFX after topical brinzolamide were equivalent to systemic acetazolamide or eye muscle surgery and were intermediate between those of soft contact lenses or convergence. Topical brinzolamide and contact lenses had equivalent LFD improvements and were less effective than convergence.

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Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

Cited by 20 publications

References 37 publications

A systematic review of animal models for experimental neuroma

A systematic review of animal models for experimental neuroma

Correlation between Target Reinnervation and Distribution of Motor Axons in the Injured Rat Sciatic Nerve

Effects of Topical Brinzolamide on Infantile Nystagmus Syndrome Waveforms: Eyedrops for Nystagmus

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