Myelinated Retinal Nerve Fibers

Straatsma, Bradley R.; Foos, Robert Y.; Heckenlively, John R.; Taylor, G.W.

doi:10.1016/0002-9394(81)90345-7

Cited by 168 publications

(102 citation statements)

References 7 publications

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“…In previous studies, MRNFs have been most commonly located in the superior peripapillary region (Straatsma et al 1981). Our study showed that the most common type was Type I (present in one temporal arcade), of which the superotemporal quadrant was the most affected retinal area consistent with that study.…”

Section: Referencessupporting

confidence: 90%

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Prevalence and clinical characteristics of myelinated retinal nerve fibres: a cross‐sectional study of Turkish individuals between 8 and 75 years

Çınar

Zengin

Küçükerdönmez

2015

Acta Ophthalmologica

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Section: Referencessupporting

confidence: 90%

“…21% of the cases were bilateral. In a series of 3,968 consecutive autopsy cases, Straatsma et al (1981) reported that MRNFs were present in 0.98% of patients and in 0.54% of eyes examined, with bilateral involvement in 7.7% of patients. Also, similar to that study, males and females were equally affected in our series.…”

Section: Referencesmentioning

confidence: 99%

Prevalence and clinical characteristics of myelinated retinal nerve fibres: a cross‐sectional study of Turkish individuals between 8 and 75 years

Çınar

Zengin

Küçükerdönmez

2015

Acta Ophthalmologica

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“…In almost all mammals, however, the optic nerve fibers are largely myelinated in EON as in submammals, but unmyelinated in ION and the retina. Myelination in the retinal nerve fiber layer is found in spontaneous [1,19,21] and experimental [15,16] cases in mammals. In the spontaneous cases, a small number of axons in the retina become myelinated by Schwann cells which have gained access to the retina.…”

Section: Discussionmentioning

confidence: 99%

Fine Structure of the Retino-Optic Nerve Junction in Dogs

Miyake

Imagawa

Uehara

2004

The Journal of Veterinary Medical Science

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ABSTRACT. In most mammals, the optic nerve fibers are myelinated in its extraocular part (EON) but not in its intraocular part (ION) and also in the retina. Transitional zone from the myelinated to unmyelinated optic nerve usually lies in the central part to the lamina cribrosa. It has been known that dogs contain exceptionally myelinated fibers in ION by light microscopy. The aim of this study was to investigate electron microscopically the retino-optic nerve junction in dogs and re-evaluate the barrier to migration of oligodendroblasts into ION. Fourteen adult dogs were used. EON was largely myelinated. In ION the percentage of myelinated fibers decreased gradually toward the retina. A narrow area of ION adjoining the retina was completely unmyelinated. In most mammalian optic nerves, oligodendrocytes are not found in ION. It has been suggested that oligodendroblasts are prevented from migrating from EON into ION; that is to say, there is a barrier to migration of oligodendroblasts. The lamina cribrosa, a dense meshwork of fibrous astrocytic processes, and a defect in the blood optic nerve barrier have been proposed as a candidate for the barrier to migration. Our results suggest, however, that these factors, at least in dogs, would be not involved in the formation of a barrier to migration of oligodendroblasts. KEY WORDS: astrocytes, canine, electron microscopy, oligodendroblast, retino-optic nerve junction.J. Vet. Med. Sci. 66(12): 1549-1554, 2004 The optic nerve looks like a peripheral nerve in gross anatomy but is comparable with a nerve tract in the central nervous system in terms of embryology and histology. However, it usually contains the connective tissue of the lamina cribrosa and pial septa, whereas the CNS does not principally contain connective tissue [8]. Furthermore, in most mammals, the optic nerve is largely myelinated in the extraocular part (EON) but not in the intraocular part (ION), and the retinal nerve fiber layer is also unmyelinated. In the majority of mammals, a transition zone from myelinated to unmyelinated fibers is located in the central part of the lamina cribrosa, or the scleral canal in animals without a distinct lamina cribrosa [9,10]. In mammals, the optic nerve fibers in ION and the retina are generally thinner than those in EON, and oligodendroblasts can not migrate into ION in embryo.Well known exceptions are the myelinated fibers distributed in the retina and ION in rabbits [3,4], and the myelinated fibers contained in ION in dogs [8,17]. In comparison with the rabbit optic nerve and retina, there are few morphological studies of the optic nerve head and the nerve fiber layer in the retina of dogs, and no electron microscopic observations. The aim of this study was to describe a fine structure of the retinal nerve fiber layer and the optic nerve in dogs with special interest to myelination in the optic nerve fibers. MATERIALS AND METHODSFourteen adult dogs used in the present study were crossbred and medium-sized. Animals were anesthetized with sodium pentobarbital (Nembu...

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“…nerve fibres occur more commonly in association with neurofibromatosis, Down's syndrome and craniofacial dysostosis. 1,8 There are, however, very few reports of familial myelination of retinal nerve fibres. 9,10 The findings of myelinated fibres, in both mother and daughter, suggest that a genetic factor could play a role.…”

Section: Commentmentioning

confidence: 99%

“…1 The causes of the haemorrhage in their series included Valslava retinopathy, macroaneurysm, branch vein occlusion, proliferative diabetic retinopathy and idiopathic. We describe here a case of bilateral premacular subhyaloid haemorrhage as a result of chemotherapy-induced pancytopenia.…”

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confidence: 99%