Myelin Oligodendrocyte Glycoprotein Antibody Persistency in a Steroid-Dependent ADEM Case

Polat, İpek; Yış, Uluç; Karaoğlu, Pakize; Ayanoğlu, Müge; Öztürk, Tülay; Güleryüz, Handan; Kurul, Semra Hız

doi:10.1542/peds.2015-1958

Cited by 9 publications

(4 citation statements)

References 10 publications

(23 reference statements)

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“…During the first episode of ADEM it has been shown to be positive in high titers and rapidly decreasing to undetectable limits after recovery. If persistent MOG antibodies detected this considered as a predicting factor for multiple sclerosis, optic neuritis relapses, and incomplete recovery of ADEM [17] .…”

Section: Discussionmentioning

confidence: 99%

Adult onset acute disseminated encephalomyelitis: A case report

Almaghrabi¹,

Saab²

2021

Radiology Case Reports

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Acute disseminated encephalomyelitis is an immune mediated demyelinating disorder of the central nervous system, it predominantly affects children in the age group between of 5-8 years. Is most widely thought to be a post-viral, post-vaccination autoimmune phenomenon. We present a case of 40 years old Pakistani male arrived to ER agitated with decrease level of consciousness and delirium, develop tonic-clonic convulsion and it was relieved by DIAZEPAM. This is the first attack to the patient with no past medical history of similar presentation. MRI showed supra and infratentorial white matter high T2/FLAIR signal abnormalities, involving supratentorial cortical and subcortical parito-occipital region, also to less extent at deep white matter predominantly right tempro-occipital region in asymmetric pattern. Involvement of juxta cortical and U fibers. MRI raised the possibility of adult onset Acute disseminated encephalomyelitis, after exclusion of other causes of juxta cortical and U fibers involvement (based on imaging analysis with consideration of clinical presentation and available lab results).

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Section: Discussionmentioning

confidence: 99%

Adult onset acute disseminated encephalomyelitis: A case report

Almaghrabi¹,

Saab²

2021

Radiology Case Reports

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“…Prolonged steroid taper has been suggested, and alternative acute therapy with plasma exchange and/or intravenous immunoglobulins (IVIG) have been explored. (8,22)To prevent attacks, mycophenolate mofetil (23)and rituximab (8,24) are the most commonly employed drugs, however emerging data suggests that MOG antibody disease responds differently to those medications compared to AQP4 NMOSD. Conventional MS treatments have not been studied in MOG antibody disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder

Salama

Pardo

Lévy

2019

Multiple Sclerosis and Related Disorders

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Background.-Serological antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with a relapsing autoimmune demyelinating disease of the central nervous system. Initially identified in the context of acute disseminated encephalomyelitis, persistent seropositivity of MOG antibodies is now recognized as a variant of neuromyelitis optica spectrum disorder (NMOSD). Objectives:The aim of the study is to describe the epidemiological and clinical features of MOG antibody positive cases and compare our findings with those previously published.Methods.-This is a retrospective descriptive study of 23 patients with MOG antibody disease who were cared for at Johns Hopkins Hospital over the period from 2015 to 2018. MOG testing was done at Johns Hopkins using the cell based assay (CBA). We describe their epidemiological and clinical features.Results.-Twenty-three patients were included in the study with a female to male ratio of 2.3:1. The mean age of the cohort was 42.6 years, while the mean age at onset was 37 years. The most frequent initial presentation was optic neuritis, followed by ADEM-like encephalopathic clinical picture and transverse myelitis. Five patients showed a monophasic disease course while the rest experienced a relapsing phenotype. Nine patients (39%) experienced immediate relapses on withdrawal of steroids.conclusions.-Our cohort showed clinical characteristics comparable with previously published reports of MOG antibody disease worldwide. Unique features of MOG antibody disease are: high frequency of optic neuritis attacks, good long term neurological recovery and sensitivity to steroid use and withdrawal.

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“…Positive titer (1: 100) persisted as long as the patient was in remission. 12 MOG antibodies were positive but did not decrease to undetectable levels. Some studies stated that MOG antibodies can still be positive at 4-69 months.…”

Section: Discussionmentioning

confidence: 85%

Detection of myelin oligodendrocyte glycoprotein antibody in pediatric patient with acute disseminated encephalomyelitis: a case report

et al. 2022

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Introduction: Acute Disseminated Encephalomyelitis (ADEM) is an immunity-mediated central nervous system demyelinating disorder. Myelin Oligodendrocyte Glycoprotein (MOG) examination provides information about a patient's ADEM development status. A positive MOG antibody can signify a first episode or incomplete recovery. This review aims to report a case of a pediatric patient with acute disseminated encephalomyelitis with positive MOG antibody. Case Presentation: We present a 5-year-old girl with symptoms of low-grade fever, encephalopathy, blurred vision, numb and tingling sensations on hands and feet, weakness, unable to walk. Head MRI (Magnetic Resonance Imaging) examination reveals lesions in the bilateral thalamus and white matter of the left parietal lobe. There was also a bilateral thickening of the optic nerves. Blood laboratory examination was relatively normal, and the MOG antibody test was positive. The patient was then treated with corticosteroids for 1 year and had 2 recurrent episodes of attacks. MOG test evaluation was still also positive 6 months after the first attack. After Intravenous immunoglobulin (IVIG) treatment was given, resulting in excellent clinical response and no recurrent attack since then. Conclusions: ADEM cases have a good prognosis and good recovery. IVIG administration, with the help of other supportive therapy, improves recovery in treating pediatric ADEM.

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Myelin Oligodendrocyte Glycoprotein Antibody Persistency in a Steroid-Dependent ADEM Case

Cited by 9 publications

References 10 publications

Adult onset acute disseminated encephalomyelitis: A case report

Adult onset acute disseminated encephalomyelitis: A case report

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder

Detection of myelin oligodendrocyte glycoprotein antibody in pediatric patient with acute disseminated encephalomyelitis: a case report

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