Myelin lipids in Wallerian degeneration of the rabbit optic nerve

Myelin Proteins, Glycoproteins, and Myelin‐Related Enzymes in Experimental Demyelination of the Rabbit Optic Nerve: Sequence of Events

“…Myelin degradation and gliosis became apparent between 32 and 90 days of Wallerian degeneration. The absence of edema, necrosis and haemorrhage in our study shows that the degradation processes, in the absence of macrophages, occurred at a much lower rate than in more traumatic situations such as physical injury to the spinal cord (Banik et al, 1980) or eye enucleation (Wender et al, 1979). In our case, it is believed that degraded myelin fragments J .…”

“…This study supports previous work (Bignami and Eng, 1973) showing that demyelination in the central nervous system is a very slow event. However, if edema, necrosis and haemorrhage occur in the tissue, demyelination can be extremely rapid (Wender et al, 1979;Banik et al, 1980). In conclusion, this work indicates that there is a sequence of events leading to the loss of myelin.…”

“…However, in the absence of a technique that can measure the protein moiety of myelin glycoprotein, we cannot distinguish between the loss of carbohydrate residues and the whole molecule itself during Wallerian degeneration. The appearance of cholesterol esters occurred later, and changes in the other myelin lipids are phenomena of late occurrence (Bignami and Eng, 1973;Wender et al, 1979).…”

August’s 2021 Full Issue PDF

“…Numerous studies have proven the survival of stem cells at the site of spinal cord injury up to 6 months after implantation and their low ability to migrate and the lack of tumorigenic potential. 16,[20][21][22] It has also been shown that one third of the injected stem cells begin to express RIP (marker of oligodendrocytes), which indicates their differentiation into immature oligodendrocytes. The other part of the stem cells expresses bIII-Tubulin, which indicates their differentiation into neurons.…”