Myelin degradation, axonal changes and expression trajectories of glial cells stimulated by rapid head insult in humans to estimate approximate time elapsed since trauma
Abstract:Background
Post severe traumatic brain injury (sTBI), axonal alterations lead to myelin loss and its degeneration. In the recovery phase, numerous intermingled biochemical pathways involving complex inflammatory reactions cloud the understanding of this yet undiscerned process that also varies with agonal period. In cases with dubious histories, approximating the survival time can be challenging, and expression levels of characteristic markers may aid forensic experts in the same.
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