Myelin‐ and microbe‐specific antibodies in guillain‐barré syndrome

Terryberry, Jeff; Sutjita, Made; Shoenfeld, Yehuda; Gilburd, Boris; Tanné, David; Lorber, Margalit; Alosachie, Iyad; Barka, Noori E.; H, Lin; Youinou, Pierre; Peter, James B.

doi:10.1002/jcla.1860090506

Cited by 33 publications

(14 citation statements)

References 124 publications

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“…Positive anti-GM2 antibodies, which are frequently found in GBS associated with cytomegalovirus infection [43] were detected. Furthermore, Terryberry et al [44] examined the cerebrospinal fluid (CSF) protein level (normal range 125-150 mg/L) that is always elevated (>400 mg/L) in GBS patients for the presence of antibodies against 18 myelin autoantigens. These results suggest a multiinfectious etiology of GBS or an increased susceptibility of GBS patients to infection, supposing that GBS is probably both a humoral and a cellular autoimmune disease induced by infection with multiple microorganisms [45].…”

Section: Influenza Vaccine and Guillain-barre Syndromementioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

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Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.Further research is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

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Section: Influenza Vaccine and Guillain-barre Syndromementioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

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“…If we suggested a connectivity 30 between the synthesizing B cells, we could interpret this figure as showing a median connectivity of about five antibodysynthesizing B cell clones in the individual patient (maximal connectivity of 15/22 antibody specificities). For the group of autoantibodies (n = 18) also investigated in this study 8 , 11% of the patient samples had a simultaneous increase of more than five structurally different autoantibodies 8 . From these data we have to conclude that the polyspecific antibody response is a basic, general property of the immune system, and not restricted to the brain.…”

Section: Polyspecific Antibodies In Blood -Guillain-barré Syndrome (Gbs)mentioning

confidence: 87%

“…Table 3 summarizes the interpretation of their results for IgG class (n = 19) and IgM class (n = 3) antibody titers (total n = 22) of the 19 different selected infectious microbes 8 . In the individual blood sample between 0 and 15 different antibody species (out of 22 species analyzed) had simultaneously-increased titers.…”

Section: Polyspecific Antibodies In Blood -Guillain-barré Syndrome (Gbs)mentioning

confidence: 99%

“…For this purpose, this article reviews the knowledge about polyspecific antibodies in autoimmune diseases with involvement of the CNS 7 , as well as the polyspecific antibody pattern with an individual connectivity in the blood of patients with a Guillain-Barré syndrome (GBS) 8 , as an extension to the better-characterized reactions in MS 1,9,10,11 . In particular, the correlations between the day-to-day variations of individual antibody concentrations shown in the blood of controls may help to get a better acceptance for the connectivity between antibodies as a general property of an immune network 12 .…”

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confidence: 99%

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Polyspecific antibodies without persisting antigen in multiple sclerosis, neurolupus and Guillain-Barré syndrome: immune network connectivity in chronic diseases

Reiber¹

2017

Arq. Neuro-Psiquiatr.

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The polyspecific antibody synthesis in multiple sclerosis (MS) gained diagnostic relevance with the frequent combination of measles-, rubella-and varicella zoster antibodies (MRZ-antibody reaction) but their pathophysiological role remains unknown. This review connects the data for intrathecal polyspecific antibody synthesis in MS and neurolupus with observations in the blood of patients with Guillain-Barré syndrome (GBS). Simultaneously increased antibody and autoantibody titers in GBS blood samples indicate that the polyspecific antibodies are based on a general property of an immune network, supported by the deterministic day-to-day concentration variation of antibodies in normal blood. Strongly correlated measles-and rubella-antibody variations point to a particular connectivity between the MRZ antibodies. The immune network, which provides serological memory in the absence of an antigen, implements the continuous change of the MRZ pattern in blood, not followed by the earlier immigrated B cells without corresponding connectivity in the brain. This may explain the different antibody patterns in cerebrospinal fluid, aqueous humor and blood of the individual MS patient. A complexity approach must implement a different view on causation in chronic diseases and causal therapies.Keywords: cerebrospinal fluid; autoimmune diseases; antibodies; M,R,Z-antibody reaction; multiple sclerosis; Guillain-Barré syndrome, neurolupus. RESUMOA síntese de anticorpos poliespecíficos em esclerose múltipla (EM) ganhou relevância diagnóstica com a combinação frequente de anticorpos contra sarampo, rubéola e varicela-zoster (reação de anticorpos MRZ), mas seu papel fisiopatológico permanece desconhecido. Esta revisão relaciona os dados da síntese intratecal de anticorpos poliespecíficos em EM e Neurolupus com observações no sangue de pacientes com síndrome de Guillain Barré (SGB). Simultaneamente, os títulos aumentados de anticorpos e autoanticorpos em amostras de sangue de SGB indicam que os anticorpos poliespecíficos se baseiam numa propriedade geral de uma rede imunitária, suportada pela variação determinística da concentração diária de anticorpos no sangue normal. As variações fortemente correlacionadas de anticorpos contra sarampo e rubéola apontam para uma conectividade particular entre os anticorpos MRZ. A rede imunitária, que fornece memória sorológica na ausência de um antígeno, implementa a mudança contínua do padrão MRZ no sangue, não seguida pelas células B que imigraram anteriormente sem conectividade no cérebro. Isto pode explicar os diferentes padrões de anticorpos no LCR, humor aquoso e sangue do paciente individual de EM. Uma abordagem complexa deve implementar uma visão diferente sobre a causalidade em doenças crônicas e terapias causais.

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“…Rubella antibodies are observed in MS patients only if they previously had the disease or the immunization (6), a mimikry by epitopes from unspecific antigens is not existing in this context (6). Therefore, the earlier interpretations of increased antibody titers in the blood of GBS patients (14), as a cause of the autoimmune disease (15) are wrong. Meanwhile we have learned that this antibody and autoantibody response is part of a polyspecific antibody synthesis due to an individually different connectivity between different B cell clones (5).…”

Section: Infections and Chronic Diseasesmentioning

confidence: 99%

Chronic Diseases with Delayed Onset After Vaccinations and Infections. A Complex Systems Approach to Pathology and Therapy

Reiber¹

2017

J Arch Mil Med

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Background: The medical community fails dramatically in the understanding of chronic diseases and development of causal therapies. Statistical associations between vaccinations or infections and autoimmune diseases or a multitude of chronic diseases remains without any scientific rational. The Gulf War illness, with an unexpected high health risk (34%) for military personnel after a manifold of vaccinations, points to the need of a scientific approach different from insufficient linear clonal selection concepts in immunology. Methods: Non-linear dynamics analyzed in time series, phase portraits, and mathematical models. Results: Three different types of chronic diseases, different from lasting acute diseases, are discriminated by Cerebrospinal fluid analysis and nonlinear dynamics. A nonlinear model for a virus-driven chronic disease explains the chronification of the infection, as one of the stable optional states between complete immunity and death. The model also helps create causal therapies and facilitating phase transitions to complete immunity based on individual connectivity in the immune network. Chronic diseases with a sudden change from stable health to a pathological but stable state are phase transitions based on metabolic fluctuations spontaneous or facilitated by external influences (via the immune, endocrine or nervous system). A reduced complexity in diseases is shown by the numerical analysis of time series (e.g., heart rate) or attractor phase portraits. In chronic diseases, with immune system associated pathology, vaccination or infection has to be regarded as a facilitator for a phase transition, like a catalyst, but not as the cause. With this causation we understand why no traces, like causative antigens, are found in Gulf War illness, chronic fatigue syndrome, post lyme syndrome, or the mild encephalitis in schizophrenia.Conclusions: The complexity approach shows why antiviral or antibiotic medications fail in chronic diseases. Disease as an emergent property should be investigated on the phenotype level. Nonlinear analysis of time series of the individual patient gives information not available from group statistics of molecular "multiscale" systems or systems biology. New research perspectives could base on the extended time of registry after vaccinations and should focus on causal therapies, which need financial support, independent from the medical-industrial complex, with its divergent interests.

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Myelin‐ and microbe‐specific antibodies in guillain‐barré syndrome

Cited by 33 publications

References 124 publications

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Polyspecific antibodies without persisting antigen in multiple sclerosis, neurolupus and Guillain-Barré syndrome: immune network connectivity in chronic diseases

Chronic Diseases with Delayed Onset After Vaccinations and Infections. A Complex Systems Approach to Pathology and Therapy

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