MyD88-silenced dendritic cells induce T-cell hyporesponsiveness and promote Th2 polarization in vivo

Disulfide-HMGB1 signals through TLR4 and TLR9 to induce inflammatory macrophages capable of innate-adaptive crosstalk in human liver transplantation

“… 43 T cells stimulated by MyD88-silenced DCs increased the production of T H 2-type cytokines, accompanied by decreased donor-specific alloreactivity. 44 Correspondingly, DCs treated with HMGB1 promoted T cell proliferation/differentiation, whereas HMGB1 blockade ameliorated chronic cardiac transplant vasculopathy and decreased T cell infiltration/pro-inflammatory cytokine production. 45 , 46 Our data support TLR4 and TLR9 signaling in enhancing antigen-presenting activity of MDMs and their capacity to stimulate alloreactivity.…”

Early markers of phenotypic heterogeneity in the induced model of systemic lupus erythematosus

“…Выключение в ДК миелоидного фактора диффе-ренцировки 88 -ключевого адаптора в передаче TLRs-сигнала -приводит к преимущественной ин-гибиции дифференцировки Th1 и соответственно изменению баланса Th1/Th2 продукции цитокинов в сторону Th2-клеток (т.е. увеличению секреции цитокинов Th2 типа IL-4 и IL-5) и соответственно торможению аллоиммунного ответа [25].…”

TIPE2 Improves the immune tolerance of human amniotic mesenchymal stem cells

“…Li et al 2014). In the rat model of heart transplantation, when compared with the control they found that the immune-tolerance group revealed the up-regulated Th2 cytokines IL-4 and IL-10 and the down-regulated Th1 cytokines INFγ and IL-2, but the condition of rejection group was opposite (Bao et al 2015). Mesenchymal stem cells (MSCs) are more than a kind of adult stem cells of high self-replication, multidirectional differentiation, cell implantation promotion and hematopoietic support but also strongly plastic and immunomodulatory, which can inhibit immune allo-response, thus inducing transplantation tolerance and a life-long immune suppression (Chamberlain et al 2007;Podesta et al 2019).…”