“…Such a model has enabled the determination that ISCs are the cells of origin in CRC (Barker et al, 2009;Zhu et al, 2009;Schepers et al, 2012). The expansion of ISCs in Xbp1 /(IEC) mice, and the desire to delineate the specific tumor-promoting role of Xbp1 deficiency specifically in IECs, prompted us to Epithelial Xbp1 suppresses tumor formation in Apc min/+ mice Inflammatory signaling is an important contributor to CAC but also to sporadic and familial CRC (Rakoff-Nahoum and Medzhitov, 2007; Lee et al, 2010), with overlapping and distinct inflammatory pathways being involved (Salcedo et al, 2010). ER stress in various organs, including the liver, skeletal muscle, adipose tissue (Ozcan et al, 2004;Gregor et al, 2009;Kars et al, 2010), and intestinal crypts (Hodin et al, 2011), is associated with obesity, which is epidemiologically closely associated with increased cancer incidence, most notably CRC (Calle et al, 2003).…”