Mycotoxins nivalenol and deoxynivalenol differentially modulate cytokine mRNA expression in Jurkat T cells

Risk assessment of Fusarium mycotoxins in Lithuanian small cereal grains

“…The most important Fusarium mycotoxins are deoxynivalenol (DON), zearalenone (ZEA), T-2 toxin (T-2), fumonisins (FB), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), fusarenon-X (FUS-X), nivalenol (NIV), diacetylnivalenol (DNIV) and neosolaniol (NEOS). They are common mycotoxins throughout the world, mainly associated with cereal crops, in particular corn, wheat, barley, rye, rice and oats (Goyarts, Dänicke, Valenta, & Ueberschär, 2007;Krska et al, 2003;Maragos, Bumsan, & Sugita-Konishi, 2006;Omurtag, Yazıcıoglu, Beyoglu, Tozan, & Atak, 2006;Severino, Luongo, Bergamo, Lucisano, & Rossi, 2006).…”

A theoretical study on vomitoxin and its tautomers

“…Different toxic properties have been associated to trichothecenes [12][13][14][15][16][17][18][19]. As mentioned in the references given, there is considerable evidence that mycotoxins produced by microorganisms in our foodstuffs constitute a serious threat to human health through likely reactions of their enols and epoxides.…”

Quantum chemical treatment of nivalenol and its tautomers

“…The findings of Rossi and co-workers [21] highlight the potential immunomodulatory effects of nivalenol and deoxynivalenol at different concentrations on a model of human lymphocyte. The assessment of mRNA transcription showed different effects of nivalenol and deoxynivalenol in modulating Th1-type cytokines, depending on the dose whereas trichothecenes were found to interact and inhibit lymphocyte proliferation through apoptosis.…”