Mycotoxins, in a Prospection in the Causes and Treatment of Metabolic Syndrome

Abstract

Metabolic syndrome (MS) and MS-related phenomena are widely distributed. For examples, cardiovascular disease and type 2 diabetes are two common diseases known to occur in MS. Till date, a number of risk factors as well as treatment strategies have been introduced in MS. Mtcotoxins are one of them. This paper features mycotoxins as a risk factor as well as therapeutic tools of MS.

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

“…Mycotoxins appear as primary or secondary contaminants via the carryover effect in the food chain ( Degen, 2017 ). Due to various biological effects, mycotoxins have come to the attention of scientists in the context of research done to discover and develop new anticancer drugs ( Islam, 2017 ; Islam et al, 2018 ). Generally, mycotoxins are ubiquitous and unavoidable harmful fungal products and vary significantly in structure and biochemical effects.…”

Dietary mycotoxin exposure and human health risks: A protocol for a systematic review

“…mycotoxins) identified in the previous step, adverse health were obtained from a literature (Google Scholar, Pubmed and Embase), as well as topic-specific organization websites from the European Food Safety Authority ( EFSA, 2020 ), World Health Organization ( WHO, 2018 ) and International Agency of Cancer ( IARC, 2023 ). A final list of 15 mycotoxin-health-related outcomes were selected: cancer, kidney disease, liver disease, immunosuppression, gastrointestinal disease ( Bennett et al, 2003 ), inflammatory bowel syndrome ( Rao Jala et al, 2018 ), alimentary toxic aleukia ( Peraica et al, 1999b ), endocrine system disease ( Kowalska et al, 2016 ), metabolic syndrome ( Islam, 2017 ), Parkinson’s disease, Alzheimer’s disease ( Arce-l et al, 2021 ), reproductive toxicity ( Kowalska et al, 2016 ), developmental problems ( Tesfamariam et al, 2019 ), cardiovascular disease ( Wang et al, 2021 ) and altered microbiota ( Rao Jala et al, 2018 ). Finally , detailed electronic search strings were developed in Pubmed, Embase, Cochrane Library, Web of Science Core Collection and Scopus, using keywords from the predefined list of major food- and beverage-related mycotoxins ( Table 2 ), in combination with “systematic review”, “ meta -analysis”, “evidence map” and “systematic search”, and without applying any filters, resulting in the output of 300, 425 and 3 articles, respectively ( Table S1, S2 and S3 of Supplementary Material ).…”