Mycotic Keratitis Caused by Fusarium solani sensu stricto (FSSC5): A Case Series

Boral, Hazal; Diepeningen, Anne van; Erdem, Elif; Yaǵmur, Meltem; Hoog, G. Sybren de; İlkit, Macit; Meis, Jacques F.; Al‐Hatmi, Abdullah M. S.

doi:10.1007/s11046-018-0280-7

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…Members of FSSC with a significant role in clinical infections in our data set comprised F. falciforme (FSSC 3+4), F. keratoplasticum (FSSC 2), F. lichenicola (FSSC 16), F. metavorans (FSSC 6), F. petroliphilum (FSSC 1), F. pseudensiforme (FSSC 33), and F. solani sensu stricto (FSSC 5) (Al-Hatmi et al, 2018a; Boral et al, 2018). Another lineage associated with opportunistic infections in FSSC that has been named is FSSC 27 ( Phialophora cyanescens = Cylindrocarpon cyanescens ), which was recently recombined as Neocosmospora cyanescens , MB 813864 (Summerbell and Scott, 2016).…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization and Antifungal Susceptibility of Clinical Fusarium Species From Brazil

et al. 2019

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Fusarium is widely distributed in the environment and is involved with plant and animal diseases. In humans, several species and species complexes (SC) are related to fusariosis, i.e., F. solani SC, F. oxysporum SC, F. fujikuroi SC, F. dimerum, F. chlamydosporum, F. incarnatum-equiseti , and F. sporotrichoides . We aimed to investigate the susceptibility of Fusarium clinical isolates to antifungals and azole fungicides and identify the species. Forty-three clinical Fusarium isolates were identified by sequencing translation elongation factor 1-alpha ( TEF1 α) gene. Antifungal susceptibility testing was performed to the antifungals amphotericin B, itraconazole, voriconazole, posaconazole, and isavuconazole, and the azole fungicides difenoconazole, tebuconazole, and propiconazole. The isolates were recovered from patients with median age of 36 years (range 2–78 years) of which 21 were female. Disseminated fusariosis was the most frequent clinical form ( n = 16, 37.2%) and acute lymphoblastic leukemia ( n = 7; 16.3%) was the most commonly underlying condition. A few species described in Fusarium solani SC have recently been renamed in the genus Neocosmospora , but consistent naming is yet not possible. Fusarium keratoplasticum FSSC 2 ( n = 12) was the prevalent species, followed by F. petroliphilum FSSC 1 ( n = 10), N. gamsii FSSC 7 ( n = 5), N. suttoniana FSSC 20 ( n = 3), F. solani sensu stricto FSSC 5 ( n = 2), Fusarium sp. FSSC 25 ( n = 2), Fusarium sp. FSSC 35 ( n = 1), Fusarium sp. FSSC18 ( n = 1), F. falciforme FSSC 3+4 ( n = 1), F. pseudensiforme ( n = 1), and F. solani f. xanthoxyli ( n = 1). Amphotericin B had activity against most isolates although MICs ranged from 0.5 to 32 μg mL -1 . Fusarium keratoplasticum showed high MIC values (8–>32 μg mL -1 ) for itraconazole, voriconazole, posaconazole, and isavuconazole. Among agricultural fungicides, difenoconazole had the lowest activity against FSSC with MICs of >32 μg mL -1 for all isolates.

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Section: Discussionmentioning

confidence: 99%

Molecular Characterization and Antifungal Susceptibility of Clinical Fusarium Species From Brazil

et al. 2019

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“…However, the overall estimate of effect was uncertain [15]. Fungal keratitis caused by F. solani has been successfully treated with a combination of 0.02% CHL and AMB (Amphotericin B), underscoring the potential of CHL as an approach to the clinical management of fungal keratitis [16]. However, data regarding treatment with a combination of CHL and VOR is still limited.…”

Section: Discussionmentioning

confidence: 99%

The combined utilization of Chlorhexidine and Voriconazole or Natamycin to combat Fusarium infections

Jiang

Tang

et al. 2020

BMC Microbiol

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Background: Fusarium species are the fungal pathogens most commonly responsible for the mycotic keratitis, which are resistant to the majority of currently available antifungal agents. The present study was designed to assess the efficacy of a combination of low doses chlorhexidine with two other commonly used drugs (voriconazole and natamycin) to treat Fusarium infections. Results: We utilized combinations of chlorhexidine and natamycin or voriconazole against 20 clinical Fusarium strains in vitro using a checkerboard-based microdilution strategy. In order to more fully understand the synergistic interactions between voriconazole and chlorhexidine, we utilized a Galleria mellonella model to confirm the combined antifungal efficacy of chlorhexidine and voriconazole in vivo. We found that for voriconazole, natamycin, and chlorhexidine as single agents, the minimum inhibitory concentration (MIC) ranges were 2-8, 4-16, and > 16 μg/ml, respectively. In contrast, the MIC values for voriconazole and chlorhexidine were reduced to 0.25-1 and 1-2 μg/ml, respectively, when these agents were administered in combination, with synergy being observed for 90% of tested Fusarium strains. Combined chlorhexidine and natamycin treatment, in contrast, exhibited synergistic activity for only 10% of tested Fusarium strains. We observed no evidence of antagonism. Our in vivo model results further confirmed the synergistic antifungal activity of chlorhexidine and voriconazole. Conclusions: Our results offer novel evidence that voriconazole and chlorhexidine exhibit synergistic activity when used to suppress the growth of Fusarium spp., and these agents may thus offer value as a combination topical antifungal treatment strategy.

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“…Se manifiesta por inflamación severa, formación de úlcera corneal e hipopion, con la presencia de hifas fúngicas dentro del estroma corneal (16) . Leber describió el primer caso de queratitis micótica en 1879 en un paciente que tenía una úlcera corneal causada por Aspergillus sp (17) . La incidencia de esta infección varía ampliamente dependiendo de las zonas geográficas, el estado socioeconómico de los pacientes y su ocupación.…”

Section: Discusionesunclassified

“…Mientras que regiones tropicales o subtropicales reportan incidencias de 35% (18) , en nuestro país, el estudio llevado a cabo en el Hospital Oftalmológico de Santa Lucía de Buenos Aires por Refojo et al y colaboradores determinó una incidencia de 17% para la misma, vemos que este resultado se acerca a los obtenidos en nuestro trabajo. En general, Fusarium y Aspergillus son los agentes etiológicos más comunmente aislados de pacientes con queratitis micótica en los trópicos, mientras que Cándida albicans en regiones templadas (17) (18) . Diferentes autores establecen que la queratitis por Fusarium es una de las infecciones más comunes de la córnea (19) .…”

Section: Discusionesunclassified

“…En el estudio epidemiológico llevado a cabo por László Kredics y colaboradores se puede apreciar la variación que estos aislamientos han tenido a lo largo de los años y en diferentes países, y se puede observar la tendencia de reportes donde este género predomina como el primer agente causal en diferentes países, seguido de Aspergillus (1) . En otras bibliografías consultadas se mantiene esta inclinación: Estados Unidos, Colombia, Paraguay (1)(17) , Brasil, China, Chile (20) , Europa, África, México (21) y Argentina (13) ; reportan este agente como el principal, mientras que los informes de India, Nepal, Sri Lanka y Bangladesh informan que Aspergillus es el agente causal más frecuente, seguido por Fusarium (17) . En nuestro trabajo, el género de hongos filamentosos que se recuperó con mayor proporción fue Fusarium sp, seguido de Aspergillus sp, de igual manera que refiere la bibliografía en esta y otras localizaciones geográficas.…”

Section: Discusionesunclassified

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Incidencia de queratitis fúngicas en el Hospital Nacional de Clínicas, Córdoba

Burghini

Fraenza

2020

Rev Fac Cien Med Univ Nac Cordoba

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Resumen Introducción: La queratitis fúngica es una infección corneal supurativa grave, generalmente ulcerosa, que puede provocar ceguera o visión reducida. Objetivos: Reportar la incidencia y los agentes causales más comunes de queratitis micóticas en el Hospital Nacional de Clínicas, de la ciudad de Córdoba. Materiales y Métodos: Se llevó a cabo un estudio retrospectivo, descriptivo y comparativo de los registros de casos con diagnóstico de queratitis fúngica en el Hospital Nacional de Clínicas en el período comprendido desde marzo del 2007 a diciembre de 2017 inclusive, analizando las variables edad, sexo y factores predisponentes. Se determinaron porcentajes y frecuencias de los microorganismos recuperados y llevando a cabo un análisis estadístico mediante una prueba de dependencia, determinamos la relación entre sexo de los pacientes e incidencia de queratitis fúngica. Resultados: De los 66 casos positivos respecto de 469 muestras totales, el 57.5% correspondió a Fusarium sp, seguido de Aspergillus sp. La principal causa de queratitis fúngica fue traumatismo con restos de vegetales. Se determinó un promedio de 6 casos diagnosticados por año. Conclusiones: El género predominante fue Fusarium sp, con una incidencia del 14,1% para esta infección en una proporción de 2.9:1 hombres respecto de mujeres.

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Mycotic Keratitis Caused by Fusarium solani sensu stricto (FSSC5): A Case Series

Cited by 10 publications

References 26 publications

Molecular Characterization and Antifungal Susceptibility of Clinical Fusarium Species From Brazil

Molecular Characterization and Antifungal Susceptibility of Clinical Fusarium Species From Brazil

The combined utilization of Chlorhexidine and Voriconazole or Natamycin to combat Fusarium infections

Incidencia de queratitis fúngicas en el Hospital Nacional de Clínicas, Córdoba

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