Mycotic endocarditis

Lombardo, Thomas A.; Rabson, Alan S.; Dodge, Harold T.

doi:10.1016/0002-9343(57)90117-1

Cited by 32 publications

(8 citation statements)

References 16 publications

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“…Six cases of cryptococcal endocarditis occurred in native valves (one vegetation occurred on the implantable cardiac defibrillator lead) ( Table 1 ). 1 , 3 , 6 – 10 Unlike previous cases, our case is the first report of cryptococcal endocarditis of native valves without a complex history of valvular disease/valve replacement, immunodeficiency/immunosuppression, or drug use. Although some pathogens, such as bacteria, a virus, and immune indicators were positive after admission, the diagnosis of cryptococcal infection was quickly confirmed by blood culture and vegetative pathology.…”

Section: Discussionmentioning

confidence: 68%

Cryptococcal endocarditis of native valves without immunodeficiency or drug abuse: a case report

Zhang

et al. 2020

J Int Med Res

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Cryptococcal endocarditis has rarely been reported. Most patients with this condition are associated with risk factors, such as structural heart disease/valve replacement, immunodeficiency/immunosuppression or drug abuse. We report a case of cryptococcal endocarditis of the native valves without any risk factors. A 50-year-old Chinese man was admitted to hospital with fever for 1 month without any underlying heart disease, immunodeficiency, or drug use. He was diagnosed as having Cryptococcus neoformans infective endocarditis and was discharged after valve replacement surgery and long-term antifungal therapy.

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Section: Discussionmentioning

confidence: 68%

Cryptococcal endocarditis of native valves without immunodeficiency or drug abuse: a case report

Zhang

et al. 2020

J Int Med Res

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“…The first case of cryptococcal endocarditis was described in 1957 in a 44-yearold man with rheumatic disease of both the mitral and aortic valve. 6 He did not develop meningeal or pulmonary symptoms and subsequently died despite antifungal treatment. Since that time, few case reports of cryptococcal endocarditis have been described (Table 1).…”

Section: Discussionmentioning

confidence: 97%

Cryptococcus neoformans Infective Endocarditis After Lung Transplantation

Fountain¹,

Rajagopalan

Carroll

et al. 2021

Infect Dis Clin Pract

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Cryptococcus neoformans infective endocarditis is rarely reported. In this report, we present a case of infective endocarditis secondary to C. neoformans in a lung transplant recipient and review the relevant literature. A 65-year-old man was hospitalized with hypoxemic respiratory failure and underwent left-sided single lung transplantation. In the setting of worsening hypoxemia, blood cultures were drawn, which grew C. neoformans. Lumbar puncture was performed, and cerebrospinal fluid (CSF) polymerase chain reaction (PCR) was also positive for Cryptococcus. Further exposure history revealed that he had raised chickens while living in Peru. Transesophageal echocardiography showed an aortic valve vegetation, and he was diagnosed with cryptococcal infective endocarditis. He received liposomal amphotericin B and flucytosine for 2 weeks and was later transitioned to fluconazole. This case highlights the need for thorough social history before lung transplantation, as pulmonary colonization with C. neoformans may result in infective endocarditis after immunosuppression.

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“…There have only been seven previously reported cases of Cryptococcal endocarditis in the literature. These cases are summarized in (Table 1) [15][16][17][18][19][20][21]. The earliest case was reported in 1957 and the most recent was published in 2011.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, culture-negative endocarditis accounts for 35% of cases [13,14]. Cryptococcus represents an extremely rare pathogen in endocarditis with only seven reported cases [15][16][17][18][19][20][21]. Little is known regarding the natural history and optimal management given the limited available data.…”

Section: Introductionmentioning

confidence: 99%

Cryptococcal Endocarditis in a Woman with Metastatic Non-Small Cell Lung Cancer: A Case Report and Review of the Literature

Kurian¹,

Peng²,

Wagner³

et al. 2020

JCMCR

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Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have demonstrated improved progression-free survival benefits and decreased treatment-related side effects, and therefore are now considered first-line of treatment of EGFR mutated, metastatic non-small cell lung carcinoma (NSCLC). Cryptococcal endocarditis is an extremely rare clinical entity with only seven reported cases in the literature. Prior cases were seen in patients with a history of rheumatic heart disease or prior valve replacement surgery. Little is known regarding the natural history and optimal management of Cryptococcal endocarditis, given the limited available data. We present a case of Cryptococcal endocarditis and meningitis in a patient with metastatic NSCLC receiving targeted therapy with an EGFR-TKI with no history of significant cardiac disease.

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Mycotic endocarditis

Cited by 32 publications

References 16 publications

Cryptococcal endocarditis of native valves without immunodeficiency or drug abuse: a case report

Cryptococcal endocarditis of native valves without immunodeficiency or drug abuse: a case report

Cryptococcus neoformans Infective Endocarditis After Lung Transplantation

Cryptococcal Endocarditis in a Woman with Metastatic Non-Small Cell Lung Cancer: A Case Report and Review of the Literature

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