Mycotic Cerebral Aneurysms Secondary to <i>Scedosporium Prolificans</i> Infection in a Patient with Multiple Sclerosis

Guadalajara, M Cristina Valencia; González, Adrián Romero; León, Sira Carrasco García de; Rojo, Marcial García; Francia, M.A. Del Real

doi:10.3988/jcn.2018.14.4.601

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Finally, several other clinical manifestations have been linked to L. prolificans infection, such as mycotic aneurysms [ 86 , 87 ], external otitis [ 1 , 88 ], sinusitis [ 1 , 77 , 89 ], peritonitis [ 77 , 90 ], onychomycosis and esophagitis [ 77 ].…”

Section: Clinical Presentationmentioning

confidence: 99%

Lomentospora prolificans: An Emerging Opportunistic Fungal Pathogen

et al. 2022

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Lomentospora prolificans is an emerging opportunistic pathogen that primarily affects immunocompromised individuals leading to disseminated disease with high mortality rates while also causing infections in healthy populations. Successful recovery from infection is difficult due to high rates of intrinsic resistance to antifungals. Rapid and readily available diagnostic methods, aggressive surgical debridement wherever appropriate, and effective and timely antifungal treatment are the pillars for successful management. Future research will need to clarify the environmental niche of the fungus, further investigate the pathophysiology of infection and define species-specific therapeutic targets.

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Section: Clinical Presentationmentioning

confidence: 99%

Lomentospora prolificans: An Emerging Opportunistic Fungal Pathogen

et al. 2022

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Methylprednisolone

2019

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Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

Neoh,

Chen,

Lanternier

et al. 2024

Clin Microbiol Rev

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SUMMARY Although Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal susceptibility, and treatment. An expansion of hosts at risk for these difficult-to-treat infections has emerged over the last two decades given the increased use of, and broader population treated with, immunomodulatory and targeted molecular agents as well as wider adoption of antifungal prophylaxis. Clinical presentations differ not only between genera but also across the different Scedosporium species. L. prolificans is intrinsically resistant to most currently available antifungal agents, and the prognosis of immunocompromised patients with lomentosporiosis is poor. Development of, and improved access to, diagnostic modalities for early detection of these rare mold infections is paramount for timely targeted antifungal therapy and surgery if indicated. New antifungal agents (e.g., olorofim, fosmanogepix) with novel mechanisms of action and less cross-resistance to existing classes, availability of formulations for oral administration, and fewer drug-drug interactions are now in late-stage clinical trials, and soon, could extend options to treat scedosporiosis/lomentosporiosis. Much work remains to increase our understanding of these infections, especially in the pediatric setting. Knowledge gaps for future research are highlighted in the review.

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Mycotic Cerebral Aneurysms Secondary to Scedosporium Prolificans Infection in a Patient with Multiple Sclerosis

Cited by 4 publications

References 7 publications

Lomentospora prolificans: An Emerging Opportunistic Fungal Pathogen

Lomentospora prolificans: An Emerging Opportunistic Fungal Pathogen

Methylprednisolone

Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

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