Mycosis fungoides with a CD56+ immunophenotype

CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: An immunohistochemical variant of mycosis fungoides

“…Our patient may be added to the recently reported rare cases of MF with a CD56 1 immunophenotype. 4,30 Like our patient, one of the previously described patients was a child who presented with hypopigmented patches and whose tumor cells also lacked both CD4 and CD8 antigens. 30 The clinical behavior in all these cases did not differ from classic MF, despite the known aggressiveness of lymphomas expressing CD56.…”

Three cases of lymphomatoid papulosis with a CD56+ immunophenotype

“…6 The association of CD56 1 and MF is also rare, with only 6 cases reported in the literature. [7][8][9] Of these, 4 showed no evidence of disease progression beyond stage Ib, one presented with stage IIb disease, and one with Sézary syndrome. Thus, the prognosis of CD56 1 MF is also similar to MF with a classic immunophenotype.…”

Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient

“…17 Expression of CD56 has been documented only in sporadic case reports. [18][19][20][21][22][23][24][25] Interestingly, also on the molecular level, variability in TCRg gene rearrangement has been described in concurrent biopsies of MF from the same patient. 26 Our findings suggest that in a single patient, there may be substantial phenotypic variation between lesions of MF present at the same time.…”