Mycosis fungoides: The pathology of extracutaneous involvement

Rappaport, Henry; Thomas, Louis B.

doi:10.1002/1097-0142(197410)34:4<1198::aid-cncr2820340431>3.0.co;2-e

Cited by 380 publications

(125 citation statements)

References 39 publications

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“…12 In some instances, the diagnosis of MF can be rendered with confidence on a skin biopsy specimen based on typical light microscopic changes, that is, marked epidermotropism of cytologically atypical T lymphocytes, clusters of these cells in the epidermis (Pautrier microabscesses), or a bandlike infiltrate containing abnormal lymphocytes in the upper dermis. [13][14][15][16] However, a definitive histopathologic diagnosis by light microscopy alone may be difficult to make in early MF 17,18 or in erythroderma in which inflammatory cells often predominate. 19 The ISCL recently proposed a diagnostic algorithm for early MF (Table 3).…”

Section: Establishment Of the Diagnosis Of Mf/ssmentioning

confidence: 99%

Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)

Olsen,

Vonderheid,

Pimpinelli

et al. 2007

Blood

1,315

1,133

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Section: Establishment Of the Diagnosis Of Mf/ssmentioning

confidence: 99%

Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)

Olsen,

Vonderheid,

Pimpinelli

et al. 2007

Blood

1,315

1,133

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“…MF is primarily limited to, but widely distributed on, the skin. However, during the advanced stages of the disease, MF has been identified in various extracutaneous regions, most commonly the lymph node, spleen, liver and lung (2). Esophageal involvement of MF has been previously identified, however cases are extremely rare (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

CD8+ mycosis fungoides with esophageal involvement: A case report

et al. 2012

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Abstract. Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma and is characterized clinically by an indolent course with slow progression. MF is limited to the skin with widespread distribution, however, extracutaneous involvement of MF occurs during the advanced stages of the disease. Esophageal involvement of MF is a rare event.In the present study, we describe the first documented case of CD8 + MF with esophageal involvement that was endoscopically diagnosed antemortem. A 70-year-old male with a 15-year history of MF presented with difficulty in swallowing. Endoscopic examination revealed a tumorous lesion with ulceration in all regions of the esophagus. Esophagus biopsy demonstrated atypical lymphocytic infiltrates with ulceration. Immunohistochemically, these atypical lymphocytes were positive for CD3, CD8 and cytotoxic granules. Therefore, a diagnosis of CD8 + MF involving the esophagus was made. Extracutaneous involvement of the esophagus in MF is extremely rare and the majority of previously reported cases have been diagnosed postmortem. Only two cases of MF with esophageal involvement endoscopically diagnosed antemortem have been previously reported and this is the first documented case of CD8 + MF with esophageal involvement diagnosed by this method. Early detection of extracutaneous involvement of MF is important for accurate treatment and endoscopic examination is a useful tool for detection of this pathology. IntroductionMycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma accounting for approximately 50% of all primary cutaneous lymphoma (1). MF is characterized clinically by an indolent course with slow progression, over years or occasionally decades, from patches to more infiltrated plaque and eventually tumor stages (1). MF is primarily limited to, but widely distributed on, the skin. However, during the advanced stages of the disease, MF has been identified in various extracutaneous regions, most commonly the lymph node, spleen, liver and lung (2). Esophageal involvement of MF has been previously identified, however cases are extremely rare (2-5).MF is characterized histopathologically by infiltrates of small to medium-sized neoplastic T lymphocytes with cerebriform nuclei demonstrating epidermotropism. The typical phenotype of neoplastic lymphocytes is CD3 + , CD4+ and CD8-(6). CD8 + MF has been identified, however, it is rare (6,7). In the present study, we report the first documented case of CD8 + MF with esophageal involvement that was diagnosed endoscopically antemortem. Patient and methodsCase report. A 70-year-old Japanese male with a 15-year history of MF presented with difficulty in swallowing. From the age of 56 years old, the patient reported observation of a gradually enlarging erythema on his left elbow. Four years following this, the patient was referred to Shiga University of Medical Science Hospital due to enlargement of the erythema across his entire body, accompanied by erosion in specific regions. Biopsy of the erythema led to di...

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“…Some autopsy studies have shown that between 70% and 90% of patients die of visceral MF involvement. Visceral involvement correlates to the severity of skin lesions, and cutaneous infections are common (4,5). It is recommended to confirm visceral involvement with biopsies and immunohistochemically because non-lymphomatous tumors can occur in long term affected patients of less than 30 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…It is a rare disease, of low incidence, and usually affects middle-aged men (2). In most cases, only the skin is involved (3), although in advanced stages it may present with extracutaneous involvement, including the gastrointestinal tract (4,5). We report the first case of MF involving the duodenal papilla, emphasizing the diagnostic approach and a brief review of the subject.…”

Section: Introductionmentioning

confidence: 99%

Unusual involvement in mycosis fungoides: Duodenal papilla

Venegas

Rubio

2015

Rev Esp Enferm Dig

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Background: Mycosis fungoides (MF) is a type of T-cell lymphoma with cutaneous involvement. It is a rare disease, of low incidence and usually affects middle-aged men. In most cases only the skin is involved although in advanced stages may present with extra cutaneous involvement including the gastrointestinal tract.Case report: We report the first case of MF with compromise of duodenal papilla, emphasizing the diagnostic approach and a brief review of the subject.Discussion: This case report proves the value of the endoscopic studies in patients with lymphoproliferative disorders, because of the impact in the diagnosis and prognosis. Also, this case report is relevant because there is no scientific evidence, as far as we know, of similar cases reported.

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Mycosis fungoides: The pathology of extracutaneous involvement

Cited by 380 publications

References 39 publications

Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)

Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)

CD8+ mycosis fungoides with esophageal involvement: A case report

Unusual involvement in mycosis fungoides: Duodenal papilla

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