Mycosis fungoides: Expression of C-myc p62 p53, bcl-2and PCNA Proteins and Absence of Association with Epstein-Barr Virus

Kanavaros, Panagiotis; Ioannidou, Despoina; Tzardi, Maria; Datseris, G; Katsantonis, John; Delidis, G.; Tosca, Androniki

doi:10.1016/s0344-0338(11)80423-1

Cited by 47 publications

(43 citation statements)

References 59 publications

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“…The number of positive cells in the 10 positive cases varied between 20% and virtually all tumor cells, and was more than 50% in 7 of 10 cases ( Table 2). Expression of p53 in a small proportion of tumor cells (1-5%), as has been reported in other studies, mainly in cases of MF (9,17,18), was not observed. Staining intensity varied, but was always easily distinguishable from reactive T cells which were consistently negative (Fig.…”

Section: Resultssupporting

confidence: 75%

p53 and bcl‐2 expression do not correlate with prognosis in primary cutaneous large T‐cell lymphomas

Haselen¹,

Vermeer²,

Toonstra³

et al. 1997

J Cutan Pathol

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Overexpression of p53 protein in cutaneous T‐cell lymphoma (CTCL) has been reported in primary cutaneous large T‐cell lymphomas (PCLTCL) and has been associated with tumor progression and transformation in mycosis fungoides. However, the prognostic significance of p53 expression has not been studied thus far. In the present study we investigated the expression of p53 as well as bcl‐2 protein in 27 PCLTCL, including 19 CD30‐positive and 8 CD30‐negative lymphomas, retrieved from the registry of the Dutch Cutaneous Lymphoma Working Group. The results were correlated with follow‐up data and proliferative activity, as assessed by the percentage of MIB‐1 positive tumor cells. Overexpression of p53 protein, defined as nuclear staining of more than 5% of the tumor cells, was found in 10 of 27 cases (37%), including 6 of 19 (32%) CD30+lymphomas and 4 of 8 (50%) CD30–PCLTCL. bcl‐2 protein was expressed in 6 of 19 (32%) CD30+lymphomas and in only 1 of 8 (12%) CD30–PCLTCL. However, no significant correlation between p53 or bcl‐2 expression and prognosis was found, neither in the whole group, nor within the CD30+ or CD30– group. In addition, no relationship between p53 expression and proliferative activity was found. The results confirm that p53 expression is more common in PCLTCL than in mycosis fungoides and Sézary syndrome. However, neither p53 nor bcl‐2 expression correlated with survival or proliferative activity.

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Section: Resultssupporting

confidence: 75%

p53 and bcl‐2 expression do not correlate with prognosis in primary cutaneous large T‐cell lymphomas

Haselen¹,

Vermeer²,

Toonstra³

et al. 1997

J Cutan Pathol

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“…18,19,35 To see whether IL-7 and IL-15 regulate bcl-2, we used the IL-7-/IL-15-dependent SeAx cell line. These cells can survive for 4 to 6 days in the absence of these 2 interleukins, and bcl-2 expression is down-regulated after 2 days (Figure 1).…”

Section: Il-7 and Il-15 Stimulate The Expression Of Cell Survival Genesmentioning

confidence: 99%

“…17 Bcl-2 expression has been found in CTCL skin lesions and is supposed to increase the survival and the resistance of CTCL cells against radiotherapy. 18,19 Two transcription factors have been found to increase the expression of the bcl-2 gene: c-Myb 20-22 and STAT5. 23 The c-myb gene was initially identified as an oncogene in acute avian leukemia retrovirus strains.…”

mentioning

confidence: 99%

Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

Qin

Zhang

Kamarashev

et al. 2001

Blood

106

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Interleukin-7 (IL-7) and IL-15 have been recently identified as growth factors for cuta-neous T-cell lymphoma (CTCL) cells, and they protect these cells from cell death. Using the CTCL cell line SeAx as a test system now shows that IL-7 and IL-15 are indeed necessary to maintain high levels of bcl-2. The up-regulation of bcl-2 was paral-leled by increased DNA-binding activities of the transcription factors STAT2, STAT5, STAT6, and c-Myb to bcl-2 gene promoter-enhancer elements. Because STAT5 and c-Myb positively regulate bcl-2, IL-7 and IL-15 may mediate some of their effects on cell death survival gene expression through these 2 factors. Constitutive activities of the 3 STAT factors and c-Myb were found in the IL-7-and IL-15-independent CTCL cell lines HUT78 and MyLa 2059. The c-Myb protein was also present in CTCL cells of the skin lesions of all investigated patients. These results indicate that IL-7 and IL-15 may increase bcl-2 expression in CTCL cells by the activation of c-myb and STAT factors. (Blood. 2001;98:2778-2783)

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“…In B-cell lymphoma, c-Myc dysregulation is well known, and recent studies have demonstrated that miRNA dysregulations affected by c-Myc play crucial roles in B-cell lymphomagenesis. Because c-Myc is also overexpressed in aggressive T-cell lymphomas, such as SzS and tumor MF [88][89][90], c-Myc/miRNA dysregulation may also be closely associated with pathogenesis. Below, we describe miRNA dysregulation in c-Myc positive lymphoma.…”

Section: Function Of Dysregulated Mirnas In Myc-expressing Malignant mentioning

confidence: 99%

“…In this manner, researching miRNAs and their targets may lead to the discovery of novel key strategies against MLs, especially aggressive types. Also in T-cell lymphoma, aggressive cases in particular, c-Myc is overexpressed and associated with poor clinical outcome [88][89][90]. This suggests that this mechanism may occur commonly between B-and T-cell lymphomas, which show high c-Myc expression.…”

Section: Function Of Dysregulated Mirnas In Myc-expressing Malignant mentioning

confidence: 99%

Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias

Ikeda

Tagawa

2014

Int J Hematol

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Mycosis fungoides: Expression of C-myc p62 p53, bcl-2and PCNA Proteins and Absence of Association with Epstein-Barr Virus

Cited by 47 publications

References 59 publications

p53 and bcl‐2 expression do not correlate with prognosis in primary cutaneous large T‐cell lymphomas

p53 and bcl‐2 expression do not correlate with prognosis in primary cutaneous large T‐cell lymphomas

Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias

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