Mycosis fungoides d'embleé: CD30-negative cutaneous large T-cell lymphoma

O'Quinn, Ryan; Zic, John A.; Boyd, Alan S.

doi:10.1067/mjd.2000.109295

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…The d'emblée form of MF is characterized by rapidly enlarging tumours not preceded by classic patch-and plaque-stage disease. However, d'emblée is now regarded as a clinical descriptive term and not as a subtype in the modern classification of primary cutaneous lymphomas (1,6,7). We believe that our case may have been d'emblée form of MF.…”

Section: Discussioncontrasting

confidence: 47%

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hattori¹,

Uchiyama²,

Tago³

et al. 2013

Acta Derm Venerol

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Mycosis fungoides usually follows an indolent clinical course. We report here a rapidly progressive case of mycosis fungoides with peculiar clinical and histological features, presenting as a haematoma-like mass on the thigh accompanied by multiple reddish brown erythematous lesions on the trunk and extremities. Histopathologically, the erythematous lesions showed epidermotropism of atypical T lymphocytes expressing CD4 and prominent syringotropism without syringometaplasia. The haematoma-like lesion consisted of diffuse and dense infiltrates of medium-to-large-sized pleomorphic lymphocytic cells expressing CD30, suggesting that CD30+ large-cell transformation had occurred. Mycosis fungoides presenting as a haematoma-like lesion is rare and may be a poor prognostic sign.

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Section: Discussioncontrasting

confidence: 47%

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hattori¹,

Uchiyama²,

Tago³

et al. 2013

Acta Derm Venerol

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“…classified in the past as generalized pagetoid reticulosis (Ketron-Goodman type) and "MF a tumeur d'amblee" 69,88 represent in fact examples of CD8+ or ␥/␦ aggressive CTCLs, and indeed 1 of our patients was previously included in the group of disseminated pagetoid reticulosis. However, it must be stressed also that these lymphomas do not show the typical progression through patch-, plaque-, and tumor-stage characteristic of "classic" MF, but rather show plaques and tumors, often ulcerated, from the onset.…”

Section: Discussionmentioning

confidence: 97%

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Massone

Chott²,

Metze³

et al. 2004

American Journal of Surgical Pathology

214

180

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A new group of subcutaneous, natural killer (NK), NK/T-cell, and other cytotoxic T-cell lymphomas of the skin has been recently described, and some have been included as distinct clinicopathologic entities in the classification of hematologic malignancies recently proposed by the World Health Organization. In the European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas, they would be classified either as CD30- large T-cell lymphoma, small/medium pleomorphic T-cell lymphoma, or subcutaneous T-cell lymphoma. Precise clinicopathologic and prognostic features of all of them have not yet been well characterized. We studied retrospectively 81 biopsies from 50 patients with subcutaneous, blastic natural killer (NK), NK/T-cell, or other non-mycosis fungoides cytotoxic T-cell lymphomas of the skin. Clinical, morphologic, phenotypical, and genetic features and data on Epstein-Barr virus association allowed us to classify our cases according to the following 7 categories: a) subcutaneous "panniculitis-like" T-cell lymphoma (SPTCL): 10 cases (estimated 5-year survival: 80%); b) blastic NK-cell lymphoma: 12 cases (estimated 5-year survival: 0%); c) nasal-type extranodal NK/T-cell lymphoma: 5 patients (estimated 5-year survival: 0%); d) epidermotropic CD8+ T-cell lymphoma: 5 cases (estimated 5-year survival: 0%); e) cutaneous gamma/delta T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); f) cutaneous alpha/beta pleomorphic T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); and g) cutaneous medium/large pleomorphic T-cell lymphoma, not otherwise specified: 2 cases. Our study shows that these cutaneous lymphomas can be classified according to precise diagnostic categories. With the exception of SPTCL, analysis of follow-up data from our patients showed that these groups of lymphomas are characterized by an aggressive course, regardless of the diagnostic category.

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“…[12–14] Many cases described as the d’emblee variant in the past may have represented other types of lymphomas. [15]…”

Section: Discussionmentioning

confidence: 99%

Mycosis Fungoides: Tumour d′emblee

Vora

Syed

Talavia

et al. 2012

Indian Dermatol Online J

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Mycosis Fungoides is a Cutaneous T-cell lymphoma characterized by infiltration of skin with patches, plaques, and nodules composed of T-lymphocytes. It is the most common type of Cutaneous T-Cell Lymphoma and accounts for almost 50% of all primary cutaneous lymphoma. Tumour d’ emblee is the term used for the patient presenting with skin tumors not preceded by patches or plaques. We report a rare case of mycosis fungoides d’ emblee variant with tumors of only 3 months duration without any preceding skin lesions.

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Mycosis fungoides d'embleé: CD30-negative cutaneous large T-cell lymphoma

Cited by 16 publications

References 14 publications

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Mycosis Fungoides: Tumour d′emblee

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