Mycosis fungoides bullosa: Report of a case and review of the literature

Bowman, Paul H.; Hogan, Daniel J.; Sanusi, I. Daniel

doi:10.1067/mjd.2001.117521

Cited by 47 publications

(75 citation statements)

References 24 publications

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“…Histologically, the blisters are reported as subcorneal, intraepidermal, and subepidermal. 7 Intraepidermal blisters, such as those seen in the present case, may appear secondary to the confluence of Pautrier microabscesses. 7 It is important to emphasize that, in addition to other dermatological aspects, ATL may rarely present as a vesicular disease.…”

Section: Discussionmentioning

confidence: 84%

“…5 Vesiculobullous lesions have been reported in around 30 cases of mycosis fungoides (MF)/Sézary syndrome, types of cutaneous T-cell lymphomas unassociated with the HTLV-I. [6][7][8][9][10][11][12][13] The blisters were generalized appearing either on normal skin or within typical MF lesions. 7 In 2 cases, the lesions predominantly involved the palmoplantar region simulating dyshidrosis.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13] The blisters were generalized appearing either on normal skin or within typical MF lesions. 7 In 2 cases, the lesions predominantly involved the palmoplantar region simulating dyshidrosis. 8,9 The aim of this article is to describe the first case of vesicular ATL with confirmation of HTLV-I proviral integration.…”

Section: Introductionmentioning

confidence: 99%

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A Dyshidrosis-Like Variant of Adult T-Cell Leukemia/Lymphoma With Clinicopathological Aspects of Mycosis Fungoides. A Case Report

Bittencourt¹,

Mota²,

Oliveira³

et al. 2009

The American Journal of Dermatopathology

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Adult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma associated with the human T-cell lymphotropic virus (HTLV-I). We describe an adult male patient clinically and pathologically diagnosed as mycosis fungoides and treated with chemotherapy after which complete involution of the lesions occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the palmoplantar regions, followed by disseminated vesiculopapules and associated lymphocytosis. A serological test performed at this time revealed HTLV-I infection, and a diagnosis of chronic ATL was made. Monoclonal integration of HTLV-I was detected in peripheral blood mononuclear cells by inverse long polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, and intraepidermal vesicles with atypical lymphocytes and an infiltration of small and atypical CD4 lymphocytes in the superficial dermis. Proliferative index (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with confirmation of HTLV-I proviral integration. The delay that occurred in diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the same clinical, histopathological, and immunohistochemical features.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Dyshidrosis-Like Variant of Adult T-Cell Leukemia/Lymphoma With Clinicopathological Aspects of Mycosis Fungoides. A Case Report

Bittencourt¹,

Mota²,

Oliveira³

et al. 2009

The American Journal of Dermatopathology

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“…Atypical lymphocytes may be seen in skin lymphoma such as mycosis fungoides (MF) and MF can be present as skin bullae, though this is rare [18,19]. Balighi et al [18] reported a case of bullous MF in which atypical lymphocytes were seen in bullae fluid.…”

Section: Discussionmentioning

confidence: 99%

“…Infections, burns, allergic contact dermatitis, autoimmune bullous disorders, drug and PUVA treatment may induce bullous lesions in MF. For a definitive diagnosis of bullous MF the presence of epidermotropism and cerebriform atypical lymphocytes in histological sections of bullous tissue is crucial [18,19]. …”

Section: Discussionmentioning

confidence: 99%

Pemphigus Vulgaris of Skin: Cytological Findings and Pitfalls

Mokhtari

Rasolmali²,

Kumar³

2012

Acta Cytologica

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Background: Pemphigus vulgaris (PV) is an autoimmune bullous lesion of the skin and mucous membranes characterized by suprabasal clefting and acantholysis. The responsible autoantibody is desmoglein 3, a protein constituent of the desmosome. The diagnosis of PV is based on histological examination and immunofluorescence study. In addition, cytological smears could also be informative for the initial diagnosis of PV. Cases: Fifteen patients, 7 men and 8 women, with skin bullous disease clinically suspected of being PV were selected for cytological study. The bullae were ruptured and two smears were prepared from the fluid and stained with the Wright-Giemsa and Papanicolaou methods. The smears were taken from both new and old bullae. They showed acantholytic cells (Tzanck cells), some with amoeboid-like cytoplasmic projections, eosinophils, basophils, various forms of typical and atypical lymphocytes with irregular nuclear borders and cerebriform nuclei and dysplastic acantholytic cells with a high nucleo-cytoplasmic ratio and prominent nucleoli. The dysplastic cells were seen only in the old bullae. Histological examination and immunofluorescence study of the lesions confirmed the diagnosis of PV. Conclusion: PV can be diagnosed by cytology. Without a clinical history of PV, the presence of atypical lymphocytes and dysplastic cells may lead to a false diagnosis of malignancy.

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