Mycosis fungoides bullosa: An unusual presentation of a rare entity

Vesicular Lymphomatoid Papulosis With DUSP22-IRF4 Rearrangement on Chromosome 6p25.3: A Case Report

“…8,[12][13][14][15][16] Blistering is an unusual clinical presentation of cutaneous T-cell lymphomas with only a few cases being reported in MF, Sézary syndrome, LyP, HTLV-1-associated adult T-cell leukemia/lymphoma, and hydroa vacciniforme-like T-cell lymphoma. [17][18][19][20][21][22][23][24][25][26][27] Therefore, other common diseases with vesicular eruption, such as viral infection, drug eruption, and autoimmune bullous disease (AIBD) should be considered first. In this case, the negative direct and indirect immunofluorescence results excluded AIBD.…”

“…Previous reports of bullous MF proposed that the possible pathogenesis of vesicular formation was the loss of cohesion between keratinocytes and basal lamina caused by aggregation of neoplastic T cells and disruption of cell adhesion by lymphokines other than cytotoxic proteins that were released from the neoplastic T cells. 17 Cytotoxic markers were commonly expressed in the CD30+ lymphoproliferative disorders, but usually absent in case of LyP with DUSP22-IRF4 rearrangement on 6p25.3 (Table 1). This case reported negative results for cytotoxic markers (TIA-1 and granzyme B) by IHC staining.…”

A case of bullous lesions in cutaneous T-cell lymphoma

“…Bullous lesions due to CTCL is extremely rare with fewer than 10 cases of bullous SS and around 30 cases of bullous MF reported in the literature. 2 , 5 The differential for this presentation is broad and includes autoimmune bullous disease, viral infection, bullous drug eruption, and TEN. Careful medication history, negative viral testing, and negative immunofluorescence and serum antibody testing were essential to ruling out these other potential causes.…”

“… 6 Histopathology of lesions from our patient demonstrated some subepidermal infiltration of Sézary cells, although not to the density reported in other bullous case reports. 2 , 5 …”