Mycosis Fungoides and Seézary Syndrome

Souteyrand, P; Thivolet, J

doi:10.1016/s0344-0338(81)80039-8

Cited by 11 publications

(1 citation statement)

References 65 publications

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“…Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of T-cell lymphomas located in the skin in which macrophages behave as M2 macrophages ( 68 , 69 ). In a study of CTCLs, a high number of CD163 + M2 TAMs was linked to a poor clinical prognosis and was correlated with the level of soluble IL-2 ( 65 ).…”

Section: Macrophages In Lymphomamentioning

confidence: 99%

Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies

Yang

et al. 2022

Front. Oncol.

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Mounting evidence has revealed that many nontumor cells in the tumor microenvironment, such as fibroblasts, endothelial cells, mesenchymal stem cells, and leukocytes, are strongly involved in tumor progression. In hematological malignancies, tumor-associated macrophages (TAMs) are considered to be an important component that promotes tumor growth and can be polarized into different phenotypes with protumor or antitumor roles. This Review emphasizes research related to the role and mechanisms of TAMs in hematological malignancies. TAMs lead to poor prognosis by influencing tumor progression at the molecular level, including nurturing cancer stem cells and laying the foundation for metastasis. Although detailed molecular mechanisms have not been clarified, TAMs may be a new therapeutic target in hematological disease treatment.

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Section: Macrophages In Lymphomamentioning

confidence: 99%

Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies

Yang

et al. 2022

Front. Oncol.

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An Ultrastructural Morphometric and Immunohistochemical Analysis of Cutaneous Lymphomas and Benign Lymphocytic Infiltrates of Skin

Payne

Grogan

Lynch³

1986

Arch Dermatol

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Our combined ultrastructural, immunohistochemical, histologic, and clinical studies over the past five years have allowed us to compile diagnostic criteria useful in the evaluation of cutaneous lymphomas. As a group, mycosis fungoides (MF) patients could be distinguished from those with benign disorders of skin using ultrastructural morphometry (mean form factor and perimeter values), but with some overlap between groups. Another approach, the ultrastructural histogram method, however, clearly separated MF patients from patients with chronic dermatitis. Immunohistochemistry was useful in distinguishing cases of cutaneous peripheral T-cell lymphoma from MF cases on the basis of the occurrence of "novel phenotypes." Neoplastic T-cell infiltrates of skin can usually be distinguished from benign polyclonal T-cell infiltrates by the presence of one T-cell subset to the exclusion of others. Patients with convoluted B-cell lymphomas could also be distinguished from MF patients using ultrastructural morphometric dual parameter analysis. The diagnostic complexity of several cutaneous T-cell lymphoma cases is illustrated. We have emphasized in this study the strength of combining quantitative electron microscopy, immunohistochemistry, and histology in the diagnostic workup of cutaneous lymphomas. This integrative approach may be necessary to assure a definitive diagnosis in difficult cases.

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