Mycosis fungoides and chronic lymphocytic leukaemia - composite T-cell and B-cell lymphomas presenting in the skin

Hull, Peter; Saxena, Anurag

doi:10.1046/j.1365-2133.2000.03679.x

Cited by 52 publications

(53 citation statements)

References 23 publications

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“…Of the 47 cases reported to that time, 18 (38%) had CLL, and we have summarized the clinical features of these cases plus 8 additional cases in table 1[13,14,15,16,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. It should be noted that 3 cases from the literature had skin lesions that were clinically atypical for CTCL.…”

Section: Discussionmentioning

confidence: 99%

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2007

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Introduction: The simultaneous presentation of chronic B-cell lymphocytic leukemia (B-CLL) and cutaneous T-cell lymphoma (CTCL) is extremely rare. Case Report: We describe a patient with B-CLL and Sézary syndrome (SS), an erythrodermic and leukemic variant of CTCL. Despite treatment, the SS progressed to involve internal organs and eventual death of the patient from sepsis. This is the first reported case of SS coexisting with chronic lymphocytic leukemia in which an anti-Vβ13.6 antibody was used to serially track changes in circulating neoplastic T cells vis-à-vis neoplastic B cells and to detect neoplastic T cells in ascitic fluid near the end of the patient’s life. Discussion: We speculate that the coexistence of B-CLL and CTCL is the result of an initiating genetic or epigenetic defect at the level of the common lymphoid stem cell that predisposes both B-cell and T-cell lineages to additional oncogenic changes at a more advanced stage of differentiation.

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Section: Discussionmentioning

confidence: 99%

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2007

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“…11,12 In addition, there have been reported cases of mycosis fungoides with fungal infections. 13,14 Sulfur mustard is an alkylating agent capable of damaging DNA. Thus the carcinogenic and radiomimetic effects seen in victims of SM exposure are not surprising.…”

Section: Discussionmentioning

confidence: 99%

Sézary syndrome, Kaposi sarcoma and generalized dermatophytosis 15 years after sulfur mustard gas exposure

Emadi¹,

Babamahmoodi²,

Poursaleh³

et al. 2012

J Dermatol Case Rep

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Background:The relationship between compromised immune system and the development of malignancy, generalized dermatitis, and infection after sulfur mustard gas exposure has been established. Main observation:We introduce a 58-year-old man with an abrupt, de novo and erythrodermic eruption in 2002 that was previously exposed to sulfur mustard during the Iran -Iraq war in 1987. Six weeks after the onset of diffuse eruption, he developed papules on the glans penis and generalized dermatophytosis. A biopsy of his eruption was consistent with cutaneous T-cell lymphoma/Sézary syndrome. A complete blood count demonstrated leukocytosis, eosinophilia and atypical lymphocytosis. Subsequently, Sézary syndrome was confirmed and T-cell count with increased CD4/CD8 in flow cytometry. The biopsy of his penile papules was consistent with Kaposi's sarcoma. Conclusion:These findings suggest a causative relationship between sulfur mustard gas exposure, cutaneous T cell lymphoma and immune compromised state with opportunistic infections. (J Dermatol Case Rep. 2012; 6(3): 86-89) Sézary syndrome, Kaposi sarcoma and generalized dermatophytosis 15 years after sulfur mustard gas exposure IntroductionCutaneous T-cell lymphoma (CTCL) comprises a group of clinicopathologic entities that are neoplastic proliferation of T lymphocytes that home to the skin. Eventually the T-cells may lose their dependence on an epidermal environment for growth, and spread to the dermis, lymph nodes, blood, and viscera. 1,2The cutaneous lesions evolve from patches to plaque and tumors (mycosis fungoides), and Sézary syndrome, where the neoplastic cells circulate in the peripheral blood. The patients present with generalized exfoliation erythroderma, intense pruritus, peripheral lymphadenophaty, and abnormal hyperchromatic mononuclear cells in the skin and peripheral blood. Decreased T-cell function may lead to subsequent immune compromised status and is followed by infection. 4 Kaposi sarcoma (KS) is a vascular tumor of intermediate malignancy, histologically characterized by proliferation of lymphatic and/or vascular endothelial cells caused by the Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8. KS is a systemic disease, which can present with cutaneous lesions with or without internal involvement. Four subtypes have been described: Classic KS, affecting middle aged men of Mediterranean descent, African endemic KS, KS in iatrogenically immunosuppressed patients, and AIDS-related KS. 5Sulfur mustard gas is a potent alkylating agent that has a long history of use as a chemical warfare agent, including recent use by Iraq against Iranian soldiers and civilians. The organs most commonly affected by sulfur mustard gas (SM) are skin, eyes, and airways. Skin lesions are seen in more than 90% of the patients exposed to SM. Although the acute DOI: http://dx.doi.org/10.3315/jdcr.2012.1109 86 systemic and cutaneous effects of SM are well known, few investigations have focused on reporting the long-term carcinogenic effects. 6,7Case Repor...

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“…Bisher wurden lediglich 13 weitere Fälle publiziert [1,3,4,8,10]. Nur in 7 der bisher publizierten Fälle lag die hier beschriebene Konstellation eines gleichzeitigen Auftretens von MF und B-CLL vor.…”

Section: Diskussionunclassified

Mycosis fungoides und chronisch lymphatische B-Zell-Leukämie

et al. 2006

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The simultaneous appearance of mycosis fungoides (MF) and B-cell chronic lymphocytic leukemia (B-CLL) in the same patient is extremely rare. Only seven cases have been described in literature. A 72-year-old patient was diagnosed with coincident MF, stage Ib, and B-CLL, Binet stage A. Hypotheses on simultaneous occurrence of B- and T-cell malignancies as well as a new therapeutic option are discussed.

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Mycosis fungoides and chronic lymphocytic leukaemia - composite T-cell and B-cell lymphomas presenting in the skin

Cited by 52 publications

References 23 publications

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Sézary syndrome, Kaposi sarcoma and generalized dermatophytosis 15 years after sulfur mustard gas exposure

Mycosis fungoides und chronisch lymphatische B-Zell-Leukämie

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