Mycosis fungoides: A great imitator

Hodak, Emmilia; Amitay‐Laish, Iris

doi:10.1016/j.clindermatol.2019.01.004

Cited by 103 publications

(142 citation statements)

References 129 publications

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“…Cutaneous T-cell lymphomas (CTCL) represent a heterogeneous group of skin homing T-cell malignancies, with mycosis fungoides (MF) and its leukemic variant Sézary syndrome (SS) accounting for the majority of cases. These two variants present with highly variable clinical skin inflammation that can be mistaken for benign mimickers, such as psoriasis, atopic dermatitis and other benign inflammatory dermatoses (BID) [1][2][3]. A correct diagnosis of MF/SS can be delayed for many years, potentially leading to inappropriate therapy, disease progression, and death [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have employed “disease controls” like psoriasis and atopic dermatitis to filter out gene expression signals contributed by inflammatory processes [ 11 , 13 , 14 , 15 , 16 , 17 ]. Many BIDs display some clinical, histologic and immunologic features that resemble MF/SS [ 1 , 2 , 18 ]. While MF and SS are caused by neoplastic T cells, benign/reactive T cells play a prominent role in inflammatory symptoms and contribute inflammatory gene expression signatures that may confound early diagnosis of MF/SS [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Gene Expression Comparison between Sézary Syndrome and Lymphocytic-Variant Hypereosinophilic Syndrome Refines Biomarkers for Sézary Syndrome

Moerman-Herzog

Mehdi

Wong

2020

Cells

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Sézary syndrome (SS), an aggressive cutaneous T-cell lymphoma (CTCL) with poor prognosis, is characterized by the clinical hallmarks of circulating malignant T cells, erythroderma and lymphadenopathy. However, highly variable clinical skin manifestations and similarities with benign mimickers can lead to significant diagnostic delay and inappropriate therapy that can lead to disease progression and mortality. SS has been the focus of numerous transcriptomic-profiling studies to identify sensitive and specific diagnostic and prognostic biomarkers. Benign inflammatory disease controls (e.g., psoriasis, atopic dermatitis) have served to identify chronic inflammatory phenotypes in gene expression profiles, but provide limited insight into the lymphoproliferative and oncogenic roles of abnormal gene expression in SS. This perspective was recently clarified by a transcriptome meta-analysis comparing SS and lymphocytic-variant hypereosinophilic syndrome, a benign yet often clonal T-cell lymphoproliferation, with clinical features similar to SS. Here we review the rationale for selecting lymphocytic-variant hypereosinophilic syndrome (L-HES) as a disease control for SS, and discuss differentially expressed genes that may distinguish benign from malignant lymphoproliferative phenotypes, including additional context from prior gene expression studies to improve understanding of genes important in SS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gene Expression Comparison between Sézary Syndrome and Lymphocytic-Variant Hypereosinophilic Syndrome Refines Biomarkers for Sézary Syndrome

Moerman-Herzog

Mehdi

Wong

2020

Cells

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“…The clinical presentation of tinea corporis can be variable ( Table 1) [3][4][5][6][7][8][9][10][11][12][13][14]. It can present as erythema, papules, or plaques.…”

Section: Discussionmentioning

confidence: 99%

“…Erythema annulare centrifugum [3,4,7] Erythema chronicum migrans [5,7] Erythema gyratum repens [3,7] Papules Granuloma annulare [8] Sarcoidosis [9] Secondary syphilis [10] Plaques Mycosis fungoides [11] Nummular dermatitis [12] Pityriasis rosea [13] Psoriasis vulgaris [14] Subacute cutaneous lupus erythematosus [6]…”

Section: Gyrate Erythemamentioning

confidence: 99%

Tinea Corporis Masquerading as a Diffuse Gyrate Erythema: Case Report and a Review of Annular Lesions Mimicking a Dermatophyte Skin Infection

Diep¹,

Calame²,

Cohen³

2020

Cureus

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Tinea is a superficial fungal infection of the skin. Gyrate erythemas are reactive conditions that present as annular red lesions. A 61-year-old woman was diagnosed with tinea corporis whose skin lesions morphologically mimicked a gyrate erythema. She presented with diffuse annular plaques affecting the left side of her chest and abdomen that did not respond to a combination antifungal-corticosteroid cream for six-month duration. The appearance and clinical differential diagnosis included a gyrate erythema. Initial evaluation of the skin biopsy from the lesion's edge demonstrated a spongiotic dermatitis, and staining for fungal organisms was negative. However, deeper sections and a different fungal stain revealed hyphae in the stratum corneum and established a diagnosis of tinea corporis. The PubMed database was used to review the following terms: tinea corporis, gyrate erythema, and tinea incognito. Relevant papers and references cited in those papers that were generated by the search were used. Tinea corporis, especially if previously treated with topical corticosteroids, can masquerade as other dermatoses including a gyrate erythema. Correlation of clinical presentation and pathology findings is essential, especially if the biopsy results do not confirm the suspected clinical diagnosis. Consideration to perform deeper sections or additional special stains or both should also be entertained when the initial pathology observations do not support the presumptive diagnosis based on clinical morphology and history.

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“…In turn, MF is classified into four stages, with the system form being defined as Sézary Syndrome [2]. Certain authors have identified the disease as a "great imitator" because it can be presented as benign inflammatory skin disorders either clinically, both clinically and histopathologically [3]. For this reason, it is recommended that the diagnosis for this type of disease to be based on the correlation between clinical presentation, histopathology, and T-cell monoclonality detected by molecular studies [4].…”

Section: Introductionmentioning

confidence: 99%

Erythema chronicum migrans like- T cell lymphoma: First description in the medical literature. Successful management with methotrexate and methylprednisolone aceponate!

Temelkova¹,

Tchernev²

2019

CRDOA

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The group of cutaneous T-cell lymphomas (CTCL) or the so-called Mycosis fungoides (MF) is also referred to as a “great imitator" and in some cases may be misinterpreted as benign inflammatory skin disorders. Difficulties could arise both clinically and histopathologically, especially in the early stages of the disease. For this reason, it is recommended that the diagnosis of MF to follow a three-stage pattern of behavior and be performed on the basis of clinic, histopathology and immunohistochemistry.

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Mycosis fungoides: A great imitator

Cited by 103 publications

References 129 publications

Gene Expression Comparison between Sézary Syndrome and Lymphocytic-Variant Hypereosinophilic Syndrome Refines Biomarkers for Sézary Syndrome

Gene Expression Comparison between Sézary Syndrome and Lymphocytic-Variant Hypereosinophilic Syndrome Refines Biomarkers for Sézary Syndrome

Tinea Corporis Masquerading as a Diffuse Gyrate Erythema: Case Report and a Review of Annular Lesions Mimicking a Dermatophyte Skin Infection

Erythema chronicum migrans like- T cell lymphoma: First description in the medical literature. Successful management with methotrexate and methylprednisolone aceponate!

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