Mycosides: a New Class of Type-Specific Glycolipids of Mycobacteria

Smith, Donald W.; Randall, H. M.; Maclennan, A. P.; Lederer, E.

doi:10.1038/186887a0

Cited by 69 publications

(30 citation statements)

References 3 publications

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“…Subtle structural variability of these molecules generates phenotypic heterogeneity between the different mycobacterial species. Despite the characterization of first GPL structure (6) and the genetic cluster (7), precise chemistry as well as mechanism involved in synthesizing the acyl chain component of GPL is not clear.…”

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confidence: 99%

Retrobiosynthetic Approach Delineates the Biosynthetic Pathway and the Structure of the Acyl Chain of Mycobacterial Glycopeptidolipids

Vats

Singh

Mukherjee

et al. 2012

Journal of Biological Chemistry

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Background: Precise chemical structure and biosynthetic pathway of the acyl chain of mycobacterial glycopeptidolipids (GPLs) is unknown. Results: Polyketide synthases dictate biosynthesis and determine hydroxylation at C-5 position of the GPL acyl chain. Conclusions: Retrobiosynthetic studies establish the role of bimodular polyketide synthase and fatty acyl-AMP-ligase in GPL biosynthesis. Significance: The long-standing ambiguity on the accurate structure and the biosynthetic mechanism of GPLs was resolved.

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confidence: 99%

Retrobiosynthetic Approach Delineates the Biosynthetic Pathway and the Structure of the Acyl Chain of Mycobacterial Glycopeptidolipids

Vats

Singh

Mukherjee

et al. 2012

Journal of Biological Chemistry

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“…This lipid is characteristic of M. tubeculosis and M. bovis and classified as one related to mycosides (the type-specific mycobacterial glycolipid) despite the lack of sugar moiety (Smith et al, 1960). Their possible surface location in mycobacteria grown in vitro and in vivo has been pointed out by Goren (1972) and Draper and Rees (1973).…”

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confidence: 98%

A Suggested Role of a Host-Parasite Lipid Complex in Mycobacterial Infection

Kondo

Kanai

1976

JJMSB

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“…So, DIM is regarded as an indicator lipid for these two species of mycobacteria (Smith et al, 1960). Kanai, Wiegeshaus and Smith (1970) first demonstrated the presence of DIM in mouse lung-derived organisms of M. bovis (Ravenel).…”

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confidence: 99%