Mycoplasmal lipoprotein p37 binds human protein HER2

Wu, Jun; Wu, Lijuan; Fang, Cheng; Nie, Rong; Wang, Jiamou; Wang, Xuan; Liu, Wenbin

doi:10.1016/j.micres.2016.08.003

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further explore the underlying mechanisms in HCC cells, we analyzed the expression of molecules reported to interact with p37 9 , 22 , 23 , 24 , 25 in TFAM‐knockdown cells using RNA sequencing data. 14 As shown in Figure 4A , ANXA2 was the most upregulated gene at the mRNA level in HCC cells with TFAM knockdown.…”

Section: Resultsmentioning

confidence: 99%

Downregulated mitochondrial transcription factor A enhances mycoplasma infection to promote the metastasis of hepatocellular carcinoma

Wang

Hong

et al. 2023

Cancer Science

View full text Add to dashboard Cite

Mycoplasma is widespread in various hosts and may cause various diseases in animals. Interestingly, the occurrence of mycoplasma infection was observed in many tumor types. However, the mechanism regulating its infection is far from clear. We unexpectedly found that the knockdown of mitochondrial transcription factor A (TFAM) remarkably enhanced mycoplasma infection in hepatocellular carcinoma (HCC) cells. More importantly, we found that mycoplasma infection facilitated by TFAM knockdown significantly promoted HCC cell metastasis. Mycoplasma infection was further found to be positively correlated with poor prognosis in patients with HCC. Mechanistically, the decreased TFAM expression upregulated the transcription factor Sp1 to increase the expression level of Annexin A2 (ANXA2), which was reported to interact with membrane protein of mycoplasma. Moreover, we found that mycoplasma infection enhanced by the TFAM downregulation promoted HCC migration and invasion by activating the nuclear factor‐κB signaling pathway. The downregulation of TFAM enhanced mycoplasma infection in HCC cells and promoted HCC cell metastasis. Our study contributes to the understanding of the pathological role of mycoplasma infection and provides supporting evidence that targeting TFAM could be a potential strategy for the treatment of HCC with mycoplasma infection.

show abstract

Section: Resultsmentioning

confidence: 99%

Downregulated mitochondrial transcription factor A enhances mycoplasma infection to promote the metastasis of hepatocellular carcinoma

Wang

Hong

et al. 2023

Cancer Science

View full text Add to dashboard Cite

show abstract

“…Mycoplasma hyorhinis membrane protein P37 is a functional protein intensively studied for its role in tumor behaviors[ 36 , 42 ]. ANXA2[ 43 ] and HER2[ 44 ] are two known binding sites of P37. Recent data indicated that P37 promoted tumor progression through its interaction with ANXA2 in host cells, while P37 antibodies, a polypeptide A2PP (a 30 amino acids polypeptide within the N-terminal of ANXA2), and anti-mycoplasma reagent like MYCO I, were able to block this interaction[ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2

Liu

Guo

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Mycoplasma infection has been reported to be associated with cancer migration, invasion, epithelial-mesenchymal transition as well as the resistance to nucleoside analogues chemotherapeutic drugs. In this study, we found that the sensitivity of hepatocarcinoma cells to Cisplatin, Gemcitabine and Mitoxantrone was increased by mycoplasma elimination. Similar to the effect of anti-mycoplasma agent, interrupting the interaction between Mycoplasma hyorhinis membrane protein P37 and Annexin A2 of host cells using the N-terminal of ANXA2 polypeptide enhanced the sensitivity of HCC97L cells to Gemcitabine and Mitoxantrone. Meanwhile, we did not observe any changes in expression or distribution of multidrug resistance associated transporters, ATP-Binding Cassette protein B1, C1 and G2, on the removal of mycoplasma. These results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored.

show abstract

Mycoplasma hyorhinis infection promotes tyrosine kinase inhibitor (TKI) resistance in lung adenocarcinoma patients

Dai

Zhong

Liu

et al. 2021

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Mycoplasmal lipoprotein p37 binds human protein HER2

Cited by 3 publications

References 19 publications

Downregulated mitochondrial transcription factor A enhances mycoplasma infection to promote the metastasis of hepatocellular carcinoma

Downregulated mitochondrial transcription factor A enhances mycoplasma infection to promote the metastasis of hepatocellular carcinoma

Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2

Mycoplasma hyorhinis infection promotes tyrosine kinase inhibitor (TKI) resistance in lung adenocarcinoma patients

Contact Info

Product

Resources

About