Mycoplasma Pneumoniae Meningoencephalitis

Smith, Chris; Sangster, G.

doi:10.3109/inf.1972.4.issue-1.14

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…Estas ocurren con mayor frecuencia en niños, generalmente entre 1 y 21 días después de haber comenzado con un cuadro respiratorio, aunque alrededor del 20% de los pacientes no tiene antecedentes de síntomas respiratorios previos 4,6 . Entre las manifestaciones neurológicas descritas con mayor frecuencia destacan meningoencefalitis, meningitis aséptica, encefalitis, mielitis transversa, ataxia cerebelosa aguda, psicosis, neuropatía de nervios craneanos y periféricos, síndrome de Guillain Barré, parálisis de Bell, sordera neurosensorial y EDA [1][2][3][4][6][7][8][9][10][11] . Este compromiso neurológico puede regresar totalmente o dejar déficit residual, que en ocasiones es severo.…”

Section: Discussionunclassified

“…La patogenia de las complicaciones neurológicas relacionadas con infección por M. pneumoniae es aún desconocida [1][2][3][4]6,9,10 . Se han postulado varios mecanismos, como la invasión directa del SNC, hipótesis que se sustenta en la detección de M. pneumoniae en el LCR y en el tejido cerebral, mediante aislamiento y técnica de RPC, fenómeno que se ha postulado sería el responsable de aquellos cuadros con un pródromos breve, menor de 5 a 7 días 1,2,4,[6][7][8]10 .…”

Section: Discussionunclassified

“…Mycoplasma pneumoniae es un reconocido patógeno del aparato respiratorio, que produce infecciones altas y bajas de diversa severidad, y es también responsable de numerosas y variadas manifestaciones extrapulmonares, como miocarditis y pericarditis, anemia hemolítica y trombocitopenia, artritis y artralgias, hepatitis, pancreatitis, compromiso mucocutáneo diverso, además de manifestaciones neurológicas, que constituyen los cuadros extrapulmonares más frecuentes, determinando un amplio espectro clínico, desde irritación meníngea leve a enfermedad neurológica severa [1][2][3] .…”

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Manifestaciones neurológicas asociadas a infección por Mycoplasma pneumoniae

P.¹,

G.²,

R.³

et al. 2004

Rev. chil. infectol.

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Neurological clinical manifestations associated to Mycoplasma pneumoniae infection Mycoplasma pneumoniae, a well known respiratory pathogen, causes several extrapulmonary manifestations, being neurological diseases the most frequent. We present an 8 year old girl, with prolonged fever of unknown origin associated to Mycoplasma pneumoniae complicated with acute disseminated encephalomyelitis (ADE). Other six cases of: aseptic meningitis (1), meningoencephalitis (1), Guillain Barré Syndrome (GBS) (1) and facial paralysis (3) are reported. Pathogenesis of neurological complications associated to M. pneumoniae infection remains unknown, hypothesizing that some of them are due to CNS mycoplasma invasion and those with prolonged prodroms, as ADE, GBS and tranverse myelitis, could be considered immune mediated diseases. In our institution, where mycoplasma PCR detection technics are unavailable, we use mycoplasma IgM antibodies (ELISA) measurement or ascending titers of specific IgG. The impact of antimicrobial treatment to control these neurological symptoms is unclear and prescription of immunomodulation therapy has been promoted by some experts.

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Section: Discussionunclassified

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Manifestaciones neurológicas asociadas a infección por Mycoplasma pneumoniae

P.¹,

G.²,

R.³

et al. 2004

Rev. chil. infectol.

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“…Singular cases of acute psychosis with confusion and hallucinations in connection with mycoplasma pneumoniae infection have been described before in 10-to 12-year-old boys and girls (Balassanian & Robbins, 1967;Smith & Sangster, 1972). Complete recovery in a couple of weeks has been the rule.…”

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confidence: 90%

Schizophreniform psychosis in a case of mycoplasma pneumoniae encephalitis

Gillberg

1980

J Autism Dev Disord

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A case of a 9-year-old girl with subacute schizophreniform psychosis following infection with mycoplasma pneumoniae is reported. A hasty--and faulty--etiological diagnosis of disturbed family interaction caused additional suffering in a situation in which worries were already overwhelming. A meticulous search for underlying organic background as well as for psychosocial factors is called for in every case of atypical schizophreniform psychosis.

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“…Meningitis is usually a mild manifestation[11,30]. Myelitis may appear in different forms: diffuse, transverse [19 11, 31, 32], or poliolike[33]. In addition, there are descrip-…”

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confidence: 99%

CNS Manifestations Associated with Mycoplasma pneumoniae Infections: Summary of Cases at the University of Helsinki and Review

Koskiniemi

1993

Clinical Infectious Diseases

175

113

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CNS manifestations appear in one of 1,000 patients with Mycoplasma pneumoniae-associated infections. Encephalitis is the most frequent manifestation, but cases of meningitis, myelitis, and polyradiculitis, as well as many other symptoms (e.g., coma, ataxia, psychosis, and stroke), have been reported. The onset of these manifestations is usually acute, with lowered consciousness, convulsions, pareses, and other neurological signs. Severe, even fatal, cases are known. The pathophysiology of CNS manifestations is unknown. To our knowledge, M. pneumoniae has never been isolated from brain tissue, but instead it has been recovered from CSF specimens in at least seven cases. Besides direct invasion of M. pneumoniae into the brain, neurotoxic or autoimmune reaction within the brain tissue is suspected. At neuropathological examination, edema, demyelination, and microthrombi have been described. Improved diagnostic methods may reveal the pathophysiology of CNS manifestations associated with M. pneumoniae infection.

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Mycoplasma Pneumoniae Meningoencephalitis

Cited by 10 publications

References 19 publications

Manifestaciones neurológicas asociadas a infección por Mycoplasma pneumoniae

Manifestaciones neurológicas asociadas a infección por Mycoplasma pneumoniae

Schizophreniform psychosis in a case of mycoplasma pneumoniae encephalitis

CNS Manifestations Associated with Mycoplasma pneumoniae Infections: Summary of Cases at the University of Helsinki and Review

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