Mycoplasma pneumoniae detection with PCR in renal tissue of a patient with acute glomerulonephritis

Laso, María del Carmen; Cadario, María Estela; Haymes, Laura; Grimoldi, Irene; Balbarrey, Ziomara; Casanueva, Enrique

doi:10.1007/s00467-006-0179-2

Cited by 13 publications

(4 citation statements)

References 11 publications

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“…Acute glomerulonephritis of various types, nephrotic syndrome, interstitial nephritis, and IgA nephropathy have occasionally been described in association with M. pneumoniae infection, presumably as a result of immune complex formation. However, the organism has also been detected by PCR from a kidney biopsy specimen of a child with membranoproliferative glomerulonephritis who also had elevated IgM (263) and by immunoperoxidase staining of kidney tissue of a patient with acute interstitial cystitis (264). Renal complications can be of great clinical importance since they can lead to renal failure (265,266).…”

Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Mycoplasma pneumoniae from the Respiratory Tract and Beyond

et al. 2017

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is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening. Over the past several years there has been much new information published concerning infections caused by this organism. New molecular-based tests for detection are now commercially available in the United States, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections. More strains have had their entire genome sequences published, providing additional insights into pathogenic mechanisms. Clinically significant acquired macrolide resistance has emerged worldwide and is now complicating treatment. susceptibility testing methods have been standardized, and several new drugs that may be effective against this organism are undergoing development. This review focuses on the many new developments that have occurred over the past several years that enhance our understanding of this microbe, which is among the smallest bacterial pathogens but one of great clinical importance.

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Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Mycoplasma pneumoniae from the Respiratory Tract and Beyond

et al. 2017

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“…Acute glomerulonephritis, including nephrotic syndrome, interstitial nephritis and immunoglobulin (Ig)A nephropathy, has been associated with MP infections and is presumed to be secondary to immune complex formation [ 5 ]. There are reports documenting detection of the MP organism itself by PCR and immunoperoxidase staining from kidney tissue [ 60 , 61 ].…”

Section: Clinical Presentationmentioning

confidence: 99%

Mycoplasma pneumoniae: A Potentially Severe Infection

2018

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Mycoplasma pneumoniae infections remain one of the most common etiologies of community-acquired pneumonia (CAP). The clinical presentation and manifestations vary widely and can affect all organs of the body. Diagnosis is challenging because there are no constant findings in physical exams or laboratory or radiological assessments that indicate Mycoplasma pneumoniae pneumonia, and specific diagnostic tools are not readily available. Extrapulmonary manifestations and severe pulmonary manifestations can lead to long-term sequelae. The increasing emergence of Mycoplasma pneumoniae that is resistant to macrolides in some areas of the world and increased world travel could add to the difficulty of controlling and treating Mycoplasma pneumoniae infections. We present a concise and up-to-date review of the current knowledge of Mycoplasma pneumoniae pneumonia.

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“…An abdominal US scan revealed enlarged kidneys with enhanced echogenicity. No complications or recurrences were observed after the treatment ended (30) . Acute interstitial nephritis in a child with an MP infection was presented by Hinokiyama et al A 15-year-old patient with cough and fever developed haematuria and proteinuria, and a renal biopsy confirmed ATIN.…”

Section: Discussionmentioning

confidence: 90%

“…W badaniu USG jamy brzusznej uwidoczniono powiększone nerki o wzmożonej echogeniczności. Po zakończeniu leczenia nie odnotowano powikłań ani nawrotów (30) . Ostre śródmiąższowe zapalenie nerek u dziecka w przebiegu ostrego zakażenia MP przedstawili Hinokiyama i wsp.…”

Section: Discussionunclassified

Mycoplasma pneumoniae as an aetiological agent of acute interstitial nephritis – a case report

Mierzejewska¹,

Rustecka²,

Jobs³

et al. 2015

PEDIATR MED RODZ

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Mycoplasma pneumoniae jest bakterią atypową, powszechnie kojarzoną jako czynnik etiologiczny zakażeń dróg oddechowych. Zakażenie Mycoplasma pneumoniae może manifestować się szeregiem innych powikłań narządowych. Wśród powikłań nefrologicznych opisywano śródmiąższowe zapalenia nerek, a także kłębuszkowe zapalenia nerek z pogorszeniem ich czynności i ostrą niewydolnością. Czasami niezbędna okazywała się terapia nerkozastępcza lub steroidoterapia, zazwyczaj jednak były to zaburzenia przejściowe, ustępujące po leczeniu, o dobrym rokowaniu. W pracy przedstawiono opis przypadku ostrego śródmiąższowego zapalenia nerek, które wystąpiło u 17-letniej pacjentki w przebiegu zakażenia Mycoplasma pneumoniae. Chora skarżyła się na bóle okolicy lędźwiowej, utratę łaknienia, polidypsję, poliurię, gorączkę i wymioty; od 3 miesięcy utrzymywał się u niej kaszel. Pacjentka przyznała się do przyjęcia 5 tabletek ketoprofenu 100 mg i 2 tabletek wyciągu z konika morskiego, sprowadzonego z Ukrainy. Obserwowano podwyższone parametry zapalne, narastanie stężenia kreatyniny do 3,2 mg/dl i mocznika do 73 mg/dl oraz hipokaliemię do 2,9 mmol/l. W badaniu ogólnym moczu wykryto ślad białka, w dobowej zbiórce moczu -albuminurię i podwyższony współczynnik albuminowo-kreatyninowy. W badaniu radiologicznym klatki piersiowej uwidoczniono zmiany zapalne. Badanie serologiczne potwierdziło zakażenie Mycoplasma pneumoniae. Po zastosowanym leczeniu przyczynowym (klarytromycyna) i leczeniu objawowym objawy ustąpiły, a parametry funkcji nerek wróciły do normy. Można podejrzewać, że zapalenie płuc miało etiologię mykoplazmatyczną, a do rozwoju ostrego uszkodzenia nerek doprowadziły dwa czynniki: cewkowo-śródmiąższowe zapalenie w przebiegu infekcji Mycoplasma pneumoniae i przyjęcie dużych dawek niesterydowych leków przeciwzapalnych.Słowa kluczowe: Mycoplasma pneumoniae, manifestacje kliniczne, ostre śródmiąższowe zapalenie nerek, cewkowo --śródmiąższowe zapalenie nerek, ostra niewydolność nerek Mycoplasma pneumoniae is an atypical bacterium, widely recognised as the aetiological agent of respiratory tract infections. These infections may cause a number of complications affecting various organs. Nephrological complications of Mycoplasma pneumoniae infection include interstitial nephritis and glomerulonephritis with the deterioration of renal function and acute renal injury. In some cases, renal impairment due to Mycoplasma pneumoniae infection requires renal replacement therapy or steroid therapy, but these are usually transient disturbances which disappear after treatment. In such cases, the prognosis is good. The paper presents a case of acute interstitial nephritis in the course of Mycoplasma pneumoniae infection in a 17-year-old girl.The patient complained about pain in the lumbar region, loss of appetite, polydipsia, polyuria, fever and vomiting. She also had a cough lasting for 3 months. The girl admitted that she had consumed 5 tablets of ketoprofen 100 mg and 2 tablets of seahorse extract imported from Ukraine. During the hospitalisation an increase in ...

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Mycoplasma pneumoniae detection with PCR in renal tissue of a patient with acute glomerulonephritis

Cited by 13 publications

References 11 publications

Mycoplasma pneumoniae from the Respiratory Tract and Beyond

Mycoplasma pneumoniae from the Respiratory Tract and Beyond

Mycoplasma pneumoniae: A Potentially Severe Infection

Mycoplasma pneumoniae as an aetiological agent of acute interstitial nephritis – a case report

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