Mycoplasma pneumoniae beyond the COVID-19 pandemic: where is it?

Sauteur, Patrick M. Meyer; Chalker, Victoria J.; Berger, Christoph; Nir-Paz, Ran; Beeton, Michael L.; Pereyre, Sabine; Bebear, Cécile; Wagner, Noémie; Andreutti, Corinne; Greub, Gilbert; Agyeman, Philipp; Aebi, Christoph; Buettcher, Michael; Kottanattu, Lisa; Gaia, Valéria; Imkamp, Frank; Zbinden, Reinhard; Sidorov, Semjon; Niederer-Loher, Anita; Barbey, Florence; Egli, Adrian; Heininger, Ulrich; Schlaeppi, Chloé; Papan, Cihan; Vasconcelos, Malte Kohns; Henrich, Birgit; Mackenzie, Colin F.; Dumke, Roger; Schneider, Gerlinde; Bossuyt, Nathalie; Vermeulen, Melissa; Loens, Katherine; Westreenen, Mireille van; Verkaik, Nelianne J.; Rossum, Annemarie M. C. van; Day, Jessica; Afshar, Baharak; Peltola, Ville; Heinonen, Santtu; Renko, Marjo; Tapiainen, Terhi; Døllner, Henrik; Rodrigues, Fernanda; Matsas, Minos; Kalogera, Eleni; Petridou, Evangelia; Kopsidas, Ioannis; Zaoutis, Theoklis E.; Keše, Darja; Elinav, Hila; Michael-Gayego, Ayelet; Namkoong, Ho; Hsieh, Yu‐Chia; Maiwald, Matthias; Loo, Liat Hui; Chaudhry, Rama; Kociolek, Larry K.; Rodríguez, Nadia; Lorenz, David H.; Blakiston, Matthew

doi:10.1016/s2666-5247(22)00190-2

Cited by 27 publications

(14 citation statements)

References 5 publications

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“…There are nearly one-fifth of pregnant women are diagnosed with GDM in mainland China [ 25 ], which is significantly higher than global average estimates [ 26 ], providing the feasibility of population basis for this study. With the resurgence of mycoplasma infection, especially in infants and children this autumn, continuous surveillance has been again put on the agenda [ 27 ]. Based on our pregnancy cohort, we found that genital Mollicutes varied in different stages of GDM pregnancies, which was similar to previous study [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Transition of the genital mollicutes from the second to the third trimester of pregnancy and its association with adverse pregnancy outcomes in GDM women: a prospective, single-center cohort study from China

Xuan,

Zhao,

Hong

et al. 2024

BMC Pregnancy Childbirth

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Background The association of genital Mollicutes infection transition with adverse pregnancy outcomes was insignificant among general pregnant women, but there remains a paucity of evidence linking this relationship in gestational diabetes mellitus (GDM) women. The aim was to investigate the association between genital Mollicutes infection and transition and adverse pregnancy outcomes in GDM women, and to explore whether this association still exist when Mollicutes load varied. Methods We involved pregnant women who attended antenatal care in Chongqing, China. After inclusion and exclusion criteria, we conducted a single-center cohort study of 432 GDM women with pregnancy outcomes from January 1, 2018 to December 31, 2021. The main outcome was adverse pregnancy outcomes, including premature rupture of membrane (PROM), fetal distress, macrosomia and others. The exposure was Mollicutes infection, including Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) collected in both the second and the third trimesters, and testing with polymerase chain reaction method. The logistic regression models were used to estimate the relationship between Mollicutes infection and adverse pregnancy outcomes. Results Among 432 GDM women, 241 (55.79%) were infected with genital Mollicutes in either the second or third trimester of pregnancy. At the end of the pregnancy follow-up, 158 (36.57%) participants had adverse pregnancy outcomes, in which PROM, fetal distress and macrosomia were the most commonly observed adverse outcomes. Compared with the uninfected group, the Mollicutes (+/-) group showed no statistical significant increase in PROM (OR = 1.05, 95% CI:0.51 ∼ 2.08) and fetal distress (OR = 1.21, 95% CI: 0.31 ∼ 3.91). Among the 77 participants who were both Uu positive in the second and third trimesters, 38 participants presented a declined Uu load and 39 presented an increased Uu load. The Uu increased group had a 2.95 odds ratio (95% CI: 1.10~8.44) for adverse pregnancy outcomes. Conclusion Mollicutes infection and transition during trimesters were not statistically associated with adverse pregnancy outcomes in GDM women. However, among those consistent infections, women with increasing Uu loads showed increased risks of adverse pregnancy outcomes. For GDM women with certain Mollicutes infection and colonization status, quantitative screening for vaginal infection at different weeks of pregnancy was recommended to provide personalized fertility treatment.

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Section: Discussionmentioning

confidence: 99%

Transition of the genital mollicutes from the second to the third trimester of pregnancy and its association with adverse pregnancy outcomes in GDM women: a prospective, single-center cohort study from China

Xuan,

Zhao,

Hong

et al. 2024

BMC Pregnancy Childbirth

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“…Zhang YY 2016 6 39 0.08 Infection with and Carriage of Mycoplasma pneumoniae in Children [13] Front Microbiol Sauteur PMM 2016 7 35 0.02 Clinical manifestations in infants and children with Mycoplasma pneumoniae infection [14] PLoS One Sondergaard MJ 2018…”

Section: Rankmentioning

confidence: 99%

Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023

Liu,

Wang,

et al. 2024

Medicine

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Background: Mycoplasma pneumoniae (MP) infections occur in regional outbreaks every 3 to 7 years, lasting up to 2 years. Since this fall, there has been a significant rise in MP infections among children in China, indicating a regional epidemiological trend that imposes an increased national public health burden. To date, bibliometric methods have not been applied to studies on MP infection in children. Methods: We searched for all relevant English publications on MP pneumonia in children published from 2011 to 2023 using Web of Science. Analytical software tools such as Citespace and VOSviewer were employed to analyze the collected literature. Results: 993 articles on MP pneumonia in children were published in 338 academic journals by 5062 authors affiliated with 1381 institutions across 75 countries/regions. China led in global productivity with 56.19%. Among the top 10 prolific organizations, 8 were Chinese institutions, with Soochow University being the most active, followed by Capital Medical University and Zhejiang University. Zhimin Chen from Zhejiang University School of Medicine exhibited the highest H-index of 32. Keyword co-occurrence network analysis revealed 7 highly relevant clusters. Conclusion: The current research hotspots and frontiers in this field are primarily MP pneumonia, refractory MP pneumonia, lactate dehydrogenase, asthma, and biomarker. We anticipate that this work will provide novel insights for advancing scientific exploration and the clinical application of MP pneumonia in children.

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“…The specific epidemic pattern of M. pneumoniae is characterized by epidemics every few years owing to reduced herd immunity. [10] In the past several years, the use of NPIs to control the spread of COVID-19 worldwide has resulted in a drastically reduced incidence of multiple respiratory tract infections, such as influenza, respiratory syncytial virus, and M. pneumoniae. [11,12] The worldwide incidence of M. pneumoniae before the COVID-19 pandemic (between April 1, 2017, and March 31, 2020) was 8.61%.…”

Section: A High Incidence Of M Pneumoniae Was Observed Worldwide Afte...mentioning

confidence: 99%

“…[12] The incidence of M. pneumoniae decreased to 1.69% following the implementation of NPIs, between April 1, 2020, and March 31, 2021. [10,13] The mean incidence of M. pneumoniae was 0.7% in 20 countries in Europe, Asia, the Americas, and Oceania between 2021 and 2022. [10] Global prospective surveillance indicated that the incidence of M. pneumoniae was 0.82% between April 1, 2022, and March 31, 2023.…”

Section: A High Incidence Of M Pneumoniae Was Observed Worldwide Afte...mentioning

confidence: 99%

“…[10,13] The mean incidence of M. pneumoniae was 0.7% in 20 countries in Europe, Asia, the Americas, and Oceania between 2021 and 2022. [10] Global prospective surveillance indicated that the incidence of M. pneumoniae was 0.82% between April 1, 2022, and March 31, 2023. [5] A surveillance survey conducted from April 1 to 30 September 30, 2023, showed the re-emergence of M. pneumoniae after the lifting of the COVID-19 pandemic restrictions.…”

Section: A High Incidence Of M Pneumoniae Was Observed Worldwide Afte...mentioning

confidence: 99%

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Prevention and Treatment of Mycoplasma pneumoniae Requires Long-term Attention

Zhang,

Feng,

Wang

2024

Infect Dis Immun

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Mycoplasma pneumoniae beyond the COVID-19 pandemic: where is it?

Cited by 27 publications

References 5 publications

Transition of the genital mollicutes from the second to the third trimester of pregnancy and its association with adverse pregnancy outcomes in GDM women: a prospective, single-center cohort study from China

Transition of the genital mollicutes from the second to the third trimester of pregnancy and its association with adverse pregnancy outcomes in GDM women: a prospective, single-center cohort study from China

Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023

Prevention and Treatment of Mycoplasma pneumoniae Requires Long-term Attention

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